Dynamic cell contacts between periportal mesenchyme and ductal epithelium act as a rheostat for liver cell proliferation.
Lucía Cordero-Espinoza,Lucía Cordero-Espinoza,Lucía Cordero-Espinoza,Anna M. Dowbaj,Timo N Kohler,Timo N Kohler,Bernhard Strauss,Olga Sarlidou,German Belenguer,Clare Pacini,Nuno P. Martins,Ross Dobie,John R. Wilson-Kanamori,Richard Butler,Nicole Prior,Palle Serup,Florian Jug,Neil C. Henderson,Florian Hollfelder,Meritxell Huch +19 more
TLDR
In this article, using organoid co-cultures that recapitulate the ductal-to-mesenchymal cell architecture of the portal tract, the authors demonstrate that a subpopulation of mouse periportal mesenchymythropoietin cells exerts dual control on proliferation of the epithelium.About:
This article is published in Cell Stem Cell.The article was published on 2021-11-04 and is currently open access. It has received 28 citations till now. The article focuses on the topics: Liver cell & Ductal cells.read more
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Notch signaling pathway: architecture, disease, and therapeutics
TL;DR: In this article , a review of the history, architecture, regulatory mechanisms, contributions to physiological development, related diseases, and therapeutic applications of the NOTCH pathway is presented. But, the authors emphasize that the outcomes of NOTCH signaling are changeable and highly dependent on context.
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Organoids
Zixuan Zhao,Xinyi Chen,Anna M Dowbaj,Aleksandra Sljukic,Kaitlin M. Bratlie,Luda Lin,Eliza Li Shan Fong,Gowri Manohari Balachander,Zhaowei Chen,Alice Soragni,Meritxell Huch,Yi Arial Zeng,Qun Wang,Hanry Yu +13 more
TL;DR: Zhao et al. as discussed by the authors discussed the rationale underlying the selection and development of these materials and methods to control the cellular/tissue niche; and therefore, the structure and function of the engineered organoid.
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Understanding the cellular interactome of non-alcoholic fatty liver disease
TL;DR: In this article , the authors describe how rapidly evolving technologies such as singlecell genomics, spatial transcriptomics and single-cell ligand-receptor analyses are transforming our understanding of the cellular interactome in NASH and how this new, high-resolution information is being leveraged to develop rational new therapies for patients with NASH.
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The sirtuin family in health and disease
Qijun Wu,Tie-Ning Zhang,Huan-huan Chen,Xue-Fei Yu,Jiale Lv,Yu-Yang Liu,Yashu Liu,Gang Zheng,Junhao Zhao,Yi Fan Wei,Jing-Yi Guo,Fang-Hua Liu,Qing Chang,Yi-Xiao Zhang,Caifeng Liu,Yuhong Zhao +15 more
TL;DR: The SIRT protein family plays a variety of important roles in cellular biology such as inflammation, metabolism, oxidative stress, and apoptosis, and is considered a potential therapeutic target for different kinds of pathologies including cancer, cardiovascular disease, respiratory disease, and other conditions as mentioned in this paper .
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Liver regeneration: Cellular origin and molecular mechanisms
TL;DR: In this review, the recent studies on cell origin of newly generated hepatocytes and the underlying mechanisms of liver regeneration in homeostasis and liver injury are summarized.
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