Journal ArticleDOI
Dynamic regulatory interactions of rad51, rad52, and replication protein-a in recombination intermediates.
Tomohiko Sugiyama,Noriko Kantake +1 more
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TLDR
These results suggest a regulatory role for Rad51 that suppresses ssDNA annealing and facilitates DNA strand invasion, where Rad51-double-stranded DNA may inhibit illegitimate second-end capture to ensure the error-free repair of a DNA double-strand break.About:
This article is published in Journal of Molecular Biology.The article was published on 2009-07-03. It has received 49 citations till now. The article focuses on the topics: Replication protein A & Strand invasion.read more
Citations
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DissertationDOI
Dissection of molecular interactions of replication protein A in replication and repair
TL;DR: It is shown that DNA replication and DNA repair require different RPA-DNA interactions and that functions in repair depend on the high affinity DNAbinding domains of RPA1.
Book ChapterDOI
Preserving the Replication Fork in Response to Nucleotide Starvation: Evading the Replication Fork Collapse Point
TL;DR: The mechanisms that maintain replica‐ tion fork structure are crucial for genome maintenance, and form a primary barrier to malig‐ nant transformation.
Association analysis between genome-wide DNA methylation patterns and tobacco smoking
TL;DR: The results demonstrate wide-spread differences in the degree of methylation as a function of this environmental factor and indicate that quitting tobacco smoking presumably allows regaining the DNA methylation state of never smokers.
DissertationDOI
Function of Replication Protein A in DNA repair and cell checkpoints
TL;DR: It is concluded that DNA intermediates in different DNA metabolic pathways require different RPA binding functions and that the aromatic residues are indispensable for binding in DNA repair.
Journal ArticleDOI
Dynamic Modelling of DNA Repair Pathway at the Molecular Level: A New Perspective
TL;DR: This application is presented as an approach for medical research against cancer, since it could give insight into a possible approach with which central nodes of the networks and repair genes could be identified and controlled with the ultimate goal of aiding cancer therapy to fight the onset of cancer and its progression.
References
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Book
Molecular Cloning: A Laboratory Manual
TL;DR: Molecular Cloning has served as the foundation of technical expertise in labs worldwide for 30 years as mentioned in this paper and has been so popular, or so influential, that no other manual has been more widely used and influential.
Journal ArticleDOI
Sensing DNA Damage Through ATRIP Recognition of RPA-ssDNA Complexes
Lee Zou,Stephen J. Elledge +1 more
TL;DR: The data suggest that RPA-coated ssDNA is the critical structure at sites of DNA damage that recruits the ATR-ATRIP complex and facilitates its recognition of substrates for phosphorylation and the initiation of checkpoint signaling.
Journal ArticleDOI
Multiple Pathways of Recombination Induced by Double-Strand Breaks in Saccharomyces cerevisiae
Frédéric Pâques,James E. Haber +1 more
TL;DR: This review encompasses different aspects of DSB-induced recombination in Saccharomyces and attempts to relate genetic, molecular biological, and biochemical studies of the processes of DNA repair and recombination.
Journal ArticleDOI
Mechanism of eukaryotic homologous recombination.
TL;DR: HR accessory factors that facilitate other stages of the Rad51- and Dmc1-catalyzed homologous DNA pairing and strand exchange reaction have also been identified.
Journal ArticleDOI
REPLICATION PROTEIN A: A Heterotrimeric, Single-Stranded DNA-Binding Protein Required for Eukaryotic DNA Metabolism
TL;DR: Replication protein A (RPA) is a single-stranded DNA-binding protein that is required for multiple processes in eukaryotic DNA metabolism, including DNA replication, DNA repair, and recombination.