Journal ArticleDOI
Dysfunction of the hypothalamic-pituitary-glandular axes and relation to Child-Pugh classification in male patients with alcoholic and virus-related cirrhosis.
B. Zietz,Guntram Lock,Barbara Plach,Wolfgang Drobnik,Johannes Grossmann,Jürgen Schölmerich,Rainer H. Straub +6 more
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TLDR
Elevated basal and stimulated levels of growth hormone probably reflect compensation for low levels of IGF‐1, which are associated with deteriorating liver function and the aetiology of cirrhosis was found to have no influence on the degree of alteration of the hypothalamicpituitary‐glandular axes.Abstract:
ObjectiveTo investigate anterior pituitary function (adrenal, somatotropic, thyroid and gonadal axes, and prolactin) in relation to the Child-Pugh score in male patients with alcoholic and virus-related liver cirrhosis.MethodAnterior pituitary function was evaluated in 52 male cirrhotics (26 Child-Pread more
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Journal ArticleDOI
Review article: sarcopenia in cirrhosis – aetiology, implications and potential therapeutic interventions
Marie Sinclair,Marie Sinclair,Paul J Gow,Paul J Gow,Mathis Grossmann,Mathis Grossmann,Peter W Angus,Peter W Angus +7 more
TL;DR: Current teaching recommends the use of protein supplementation and exercise, however, this fails to address many other factors which contribute to muscle loss in this setting.
Journal ArticleDOI
Low-dose hydrocortisone in patients with cirrhosis and septic shock: a randomized controlled trial
Yaseen M. Arabi,Abdulrahman Aljumah,Ousama Dabbagh,Hani Tamim,Asgar H. Rishu,Abdulmajeed Al-Abdulkareem,Bandar Al Knawy,Ali H. Hajeer,Waleed Tamimi,Antoine Cherfan +9 more
TL;DR: Despite initial favourable effects on hemodynamic parameters, hydrocortisone therapy did not reduce mortality and was associated with an increase in adverse effects.
Journal ArticleDOI
Testosterone therapy increases muscle mass in men with cirrhosis and low testosterone: A randomised controlled trial
TL;DR: Testosterone therapy in men with cirrhosis and low serum testosterone safely increases muscle mass, bone mass and haemoglobin, and reduces fat mass and HbA1c.
Journal ArticleDOI
Diagnosis and management of toxicities of immune checkpoint inhibitors in hepatocellular carcinoma.
TL;DR: The toxicity profile of ICIs in patients with HCC is addressed, focusing on the challenges that the underlying liver disease poses to their diagnosis and management.
Book ChapterDOI
Sex Differences in Muscle Wasting
TL;DR: The similarities and differences between men and women with common wasting conditions including sarcopenia and cachexia due to cancer, end-stage renal disease/chronic kidney disease, liver disease, chronic heart failure, and chronic obstructive pulmonary disease are reviewed.
References
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Journal ArticleDOI
Transection of the oesophagus for bleeding oesophageal varices
TL;DR: Emergency ligation of bleeding oesophageal varices using the Milnes Walker technique was performed in 38 patients, and in patients with good preoperative liver function this rose to 71% and the simple scoring system for grading the severity of disturbance of liver function was found to be of value in predicting the outcome of surgery.
Journal ArticleDOI
Serum levels of cytokines in chronic liver diseases.
Herbert Tilg,Herbert Tilg,Axel Wilmer,Axel Wilmer,Wolfgang Vogel,Wolfgang Vogel,Manfred Herold,Manfred Herold,Birgit Nölchen,Birgit Nölchen,Gert Judmaier,Gert Judmaier,Christoph Huber,Christoph Huber +13 more
TL;DR: The cirrhotic group of CLD patients showed higher serum levels in IL-1 beta, IL-6, TNF-alpha, and CRP than did noncirrhotic cases, and these differences reached the level of statistical significance, suggesting that enhanced endogenous cytokine levels represent a consequence of liver dysfunction rather than of inflammatory disease.
Journal ArticleDOI
False neurotransmitters and hepatic failure.
Fischer Je,Ross J. Baldessarini +1 more
TL;DR: This hypothesis is consistent with many clinical and biochemical observations about hepatic failure, hepatic coma, and the "hepatorenal syndrome" and may explain the beneficial effects of L-dopa on the mental and circulatory status of patients in hepatic Failure and the satisfactory treatment of the hepatorenal Syndrome with large doses of metaraminol or other α-adrenergic amines.
Journal ArticleDOI
Bacterial translocation in cirrhotic rats stimulates eNOS-derived NO production and impairs mesenteric vascular contractility
Reiner Wiest,S. Das,Greg Cadelina,Guadalupe Garcia-Tsao,Sheldon Milstien,Roberto J. Groszmann +5 more
TL;DR: A link between BT to MLNs is established and increased TNF-alpha production and elevated BH(4) levels enhancing eNOS-derived NO overproduction, further impairing contractility in the cirrhotic mesenteric vasculature.
Journal ArticleDOI
Hypogonadism in alcoholic liver disease: evidence for a double defect.
David H. Van Thiel,David H. Van Thiel,Roger Lester,Roger Lester,Richard J. Sherins,Richard J. Sherins +5 more
TL;DR: No correlation between any specific biochemical assessment of the severity of liver disease and the degree of hormonal derangement was observed, but mean plasma testosterone levels were lower than normal.