Journal ArticleDOI
Educational attainment and motor burden in advanced Parkinson's disease – The emerging role of education in motor reserve
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TLDR
An inverse correlation between years of education and lower UPDRS -III motor score is found after adjusting for important covariables, suggesting education may lead to an increased ability to compensate disturbances in basal ganglia circuits affecting not only for cognitive, but also for motor aspects of PD.About:
This article is published in Journal of the Neurological Sciences.The article was published on 2017-10-15. It has received 15 citations till now.read more
Citations
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Journal ArticleDOI
Deep Learning Identifies Digital Biomarkers for Self-Reported Parkinson's Disease.
TL;DR: This study reports the top-performing smartphone-based method in the recent DREAM Parkinson's Disease Digital Biomarker Challenge for digital diagnosis of PD, using real-world accelerometer records, and paves the way for future at-home screening of PD and other neurodegenerative conditions affecting movement.
Journal ArticleDOI
Identifying the Functional Brain Network of Motor Reserve in Early Parkinson's Disease
Seok Jong Chung,Seok Jong Chung,Hee-Tae Kim,Jin Ho Jung,Phil Hyu Lee,Yong Jeong,Young H. Sohn +6 more
TL;DR: This study explored the functional brain network associated with motor reserve in early‐stage PD and found individuals with greater motor reserve may have milder motor signs than their striatal dopamine loss.
Journal ArticleDOI
Examining the Reserve Hypothesis in Parkinson's Disease: A Longitudinal Study
Pei-Chen Lee,Pei-Chen Lee,Fanny Artaud,Florence Cormier-Dequaire,Olivier Rascol,Franck Durif,Pascal Derkinderen,A. Marques,Frédéric Bourdain,Jean-Philippe Brandel,Fernando Pico,Lucette Lacomblez,Cecilia Bonnet,Christine Brefel-Courbon,Fabienne Ory-Magne,David Grabli,Stephan Klebe,Graziella Mangone,Hana You,Valérie Mesnage,Alexis Brice,Marie Vidailhet,Jean-Christophe Corvol,Alexis Elbaz +23 more
TL;DR: Whether reserve plays a role in Parkinson's disease patients has received less attention than in dementia and has been mainly examined in relation with cognitive function.
Journal ArticleDOI
Emerging Concepts of Motor Reserve in Parkinson's Disease.
TL;DR: This review summarized a series of studies investigating MR in de novo patients with PD using the data of initial clinical presentation and dopamine transporter PET scan to hypothesized that the presence of motor reserve (MR) in PD explains the individual differences in motor deficits despite similar levels of striatal dopamine depletion.
Journal ArticleDOI
Cross-sectional and longitudinal associations between total and regional white matter hyperintensity volume and cognitive and motor function in Parkinson's disease.
Vincent Pozorski,Jennifer M. Oh,Ozioma C. Okonkwo,Stephanie Krislov,Amy Barzgari,Frances Theisen,Jitka Sojkova,Barbara B. Bendlin,Sterling C. Johnson,Catherine L. Gallagher +9 more
TL;DR: Findings suggest that although PD patients do not experience greater mean WMH load than normal aged adults, comorbid WMH do exacerbate cognitive and motor symptoms in PD.
References
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Journal ArticleDOI
Clinical diagnostic criteria for dementia associated with Parkinson's disease.
Murat Emre,Dag Aarsland,Dag Aarsland,Richard G. Brown,David J. Burn,Charles Duyckaerts,Yoshikino Mizuno,Gerald A. Broe,Jeffrey L. Cummings,Dennis W. Dickson,Serge Gauthier,Jennifer G. Goldman,Christopher G. Goetz,Arnos Korczyn,Andrew J. Lees,Richard Levy,Irene Litvan,Ian G. McKeith,Warren Olanow,Werner Poewe,Niall Quinn,Christina Sampaio,Eduardo Tolosa,Bruno Dubois +23 more
TL;DR: Clinical diagnostic criteria for probable and possible PD‐D are proposed, characterized by impairment in attention, memory, executive and visuo‐spatial functions, behavioral symptoms such as affective changes, hallucinations, and apathy are frequent.
Journal ArticleDOI
Cognitive reserve in ageing and Alzheimer's disease
TL;DR: Cognitive reserve provides an explanation for differences between individuals in susceptibility to age-related brain changes or pathology related to Alzheimer's disease, whereby some people can tolerate more of these changes than others and maintain function.
Journal ArticleDOI
Cerebral white matter lesions, vascular risk factors, and cognitive function in a population‐based study The Rotterdam Study
Monique M.B. Breteler,J. C. van Swieten,M. L. Bots,D. E. Grobbee,J. J. Claus,J. H. W. Van Den Hout,F. van Harskamp,Hervé L. J. Tanghe,P.T.V.M. de Jong,J. van Gijn,Albert Hofman +10 more
TL;DR: In this article, the prevalence of white matter lesions and their relation with classic cardiovascular risk factors, thrombogenic factors, and cognitive function in an age and gender-stratified random sample from the general population were studied.
Journal ArticleDOI
The neurobiology of brain and cognitive reserve: mental and physical activity as modulators of brain disorders.
TL;DR: Animal studies that have investigated the effects of modifying mental and physical activity via experimental manipulations are reviewed, and their relevance to brain and cognitive reserve (BCR) is discussed.
Journal ArticleDOI
Risk factors for coronary heart disease and level of education the tromsø heart study
Bjarne K. Jacobsen,Dag S. Thelle +1 more
TL;DR: Adjustment of the relations between level of education and serum total cholesterol and systolic blood pressure for several variables reduced the strength of the associations, which, however, were still statistically significant.
Related Papers (5)
Examining the Reserve Hypothesis in Parkinson's Disease: A Longitudinal Study
Pei-Chen Lee,Pei-Chen Lee,Fanny Artaud,Florence Cormier-Dequaire,Olivier Rascol,Franck Durif,Pascal Derkinderen,A. Marques,Frédéric Bourdain,Jean-Philippe Brandel,Fernando Pico,Lucette Lacomblez,Cecilia Bonnet,Christine Brefel-Courbon,Fabienne Ory-Magne,David Grabli,Stephan Klebe,Graziella Mangone,Hana You,Valérie Mesnage,Alexis Brice,Marie Vidailhet,Jean-Christophe Corvol,Alexis Elbaz +23 more