Effect of Lactobacillus rhamnosus HN001 in Pregnancy on Postpartum Symptoms of Depression and Anxiety: A Randomised Double-blind Placebo-controlled Trial.
Rebecca F. Slykerman,Fiona Hood,Kristin Wickens,John F. Thompson,Christine Barthow,Rinki Murphy,Janice Kang,Judy Rowden,Peter Stone,Julian Crane,Thorsten Stanley,Peter Abels,Gordon Purdie,Robyn Maude,Edwin A. Mitchell +14 more
TLDR
Women who received HN001 had significantly lower depression and anxiety scores in the postpartum period, and this probiotic may be useful for the prevention or treatment of symptoms of depression and Anxiety postpartums.About:
This article is published in EBioMedicine.The article was published on 2017-10-01 and is currently open access. It has received 244 citations till now. The article focuses on the topics: Postpartum period & Edinburgh Postnatal Depression Scale.read more
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The Microbiota-Gut-Brain Axis
John F. Cryan,Kenneth J. O’Riordan,Caitlin S. M. Cowan,Kiran V. Sandhu,Thomaz F.S. Bastiaanssen,Marcus Boehme,Martín Gabriel Codagnone,Sofia Cussotto,Christine Fülling,Anna V. Golubeva,Katherine E. Guzzetta,Minal Jaggar,Caitriona M. Long-Smith,Joshua M. Lyte,Jason A. Martin,Alicia Molinero-Perez,Gerard M. Moloney,Emanuela Morelli,Enrique Morillas,Rory C. O'Connor,Joana S Cruz-Pereira,Veronica L. Peterson,Kieran Rea,Nathaniel L. Ritz,Eoin Sherwin,Simon Spichak,Emily M. Teichman,Marcel van de Wouw,Ana Paula Ventura-Silva,Shauna E. Wallace-Fitzsimons,Niall P. Hyland,Gerard Clarke,Timothy G. Dinan +32 more
TL;DR: Future studies will focus on understanding the mechanisms underlying the microbiota-gut-brain axis and attempt to elucidate microbial-based intervention and therapeutic strategies for neuropsychiatric disorders.
Journal ArticleDOI
Prebiotics and probiotics for depression and anxiety: a systematic review and meta-analysis of controlled clinical trials.
TL;DR: There is general support for antidepressant and anxiolytic effects of probiotics, but the pooled effects were reduced by the paucity of trials with clinical samples.
Journal ArticleDOI
Gut microbes and metabolites as modulators of blood-brain barrier integrity and brain health
TL;DR: Current evidence of the impact gut microbes and their metabolites have on blood-brain barrier integrity and brain function is summarized, and the communication networks between the gastrointestinal tract and brain, which they may modulate are summarized.
Journal ArticleDOI
The Gut-Brain Axis and the Microbiome: Mechanisms and Clinical Implications.
TL;DR: Targets within the brain gut microbiome axis have the potential to become targets for novel drug development for brain gut disorders.
Journal ArticleDOI
The Microbiota-Gut-Brain Axis: From Motility to Mood
TL;DR: The role of the microbiome as an important factor in modulating gut-brain signaling has emerged and the concept of a microbiota-gut-brain axis has been established as discussed by the authors, highlighting the role of this axis in modifying enteric and central nervous system function and how this may impact disorders such as irritable bowel syndrome and disorders of mood and affect.
References
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Detection of postnatal depression. Development of the 10-item Edinburgh Postnatal Depression Scale.
John Cox,Jeni Holden,R. Sagovsky +2 more
TL;DR: The development of a 10-item self-report scale (EPDS) to screen for Postnatal Depression in the community was found to have satisfactory sensitivity and specficity, and was also sensitive to change in the severity of depression over time.
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Expert consensus document. The International Scientific Association for Probiotics and Prebiotics consensus statement on the scope and appropriate use of the term probiotic
Colin Hill,Francisco Guarner,Gregor Reid,Glenn R. Gibson,Daniel Merenstein,Bruno Pot,Lorenzo Morelli,Roberto Berni Canani,Harry J. Flint,Seppo Salminen,Philip C. Calder,Mary Ellen Sanders +11 more
TL;DR: An expert panel was convened in October 2013 by the International Scientific Association for Probiotics and Prebiotics (ISAPP) to discuss the field of probiotics and the appropriate use and scope of the term probiotic.
A Randomized Double-blind Placebo-controlled Trial
TL;DR: The purpose of the present investigation was to evaluate the safety and effectiveness of the antiviral drug amantadine for the treatment of hepatitis C in those who had either previously failed interferon therapy or were not candidates for interferons.
Journal ArticleDOI
Ingestion of Lactobacillus strain regulates emotional behavior and central GABA receptor expression in a mouse via the vagus nerve.
Javier A. Bravo,Paul Forsythe,Marianne V. Chew,Emily Escaravage,Hélène M. Savignac,Timothy G. Dinan,John Bienenstock,John F. Cryan +7 more
TL;DR: Chronic treatment with L. rhamnosus induced region-dependent alterations in GABAB1b mRNA in the brain with increases in cortical regions and concomitant reductions in expression in the hippocampus, amygdala, and locus coeruleus, in comparison with control-fed mice, highlighting the important role of bacteria in the bidirectional communication of the gut–brain axis.
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The development of a six-item short-form of the state scale of the Spielberger State-Trait Anxiety Inventory (STAI)
TL;DR: Two studies are reported describing the development of a short-form of the state scale of the Spielberger State-Trait Anxiety Inventory (STAI) for use in circumstances where the full-form is inappropriate, and the six-item version offers a briefer and just as acceptable scale for subjects while maintaining results that are comparable to those obtained using the full form.
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