Effectiveness of Progressive Resistive Exercise (PRE) in the context of HIV: systematic review and meta-analysis using the Cochrane Collaboration protocol.
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TLDR
Performing progressive resistive exercise (PRE) or a combination of resistive and aerobic exercise at least three times per week for at least six weeks is safe and can lead to improvements in cardiorespiratory fitness, strength, weight, and body composition for adults with HIV.Abstract:
HIV is increasingly considered a chronic illness. More individuals are living longer and aging with the health-related consequences associated with HIV and multi-morbidity. Exercise is a self-management approach that can promote health for people aging with HIV. We examined the safety and effectiveness of progressive resistive exercise (PRE) interventions on immunological, virological, cardiorespiratory, strength, weight, body composition, and psychological outcomes in adults living with HIV. We conducted a systematic review using the Cochrane Collaboration protocol. Searching databases up to April 2013, we included randomized controlled trials that compared PRE with no exercise or another intervention performed at least three times per week for at least four weeks with adults living with HIV. Two reviewers independently determined study eligibility. We extracted data from included studies and assessed risk of bias using the Cochrane Collaboration risk of bias tool. Meta-analyses were conducted using random effects models with Review Manager (RevMan) computer software. Twenty studies met inclusion criteria (n = 764 participants at study completion); the majority of participants were men (77%) taking antiretroviral therapy (14/20 included studies). Exercise interventions included PRE alone (8 studies) or a combination of resistive and aerobic exercise (12 studies) ranging from 6 to 52 weeks in duration. Thirty-four meta-analyses were performed. Results demonstrated statistically significant improvements in cardiorespiratory status (maximum oxygen consumption, exercise time), strength (chest press, knee flexion), weight, and body composition (arm and thigh girth, leg muscle area) among exercisers versus non-exercisers. We found no significant differences in change in CD4 count and viral load. We were unable to perform meta-analyses for psychological outcomes however results from individual studies demonstrated improvements in health-related quality of life with exercisers compared with non-exercisers. Performing progressive resistive exercise (PRE) or a combination of resistive and aerobic exercise at least three times per week for at least six weeks is safe and can lead to improvements in cardiorespiratory fitness, strength, weight, and body composition for adults with HIV. Exercise may be considered a safe and beneficial for enhancing the health of medically stable adults aging with HIV.read more
Citations
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Physical function improvements with moderate or high-intensity exercise among older adults with or without HIV infection.
Kristine M. Erlandson,Samantha MaWhinney,Melissa P Wilson,Lilyana Gross,Sean A. McCandless,Thomas B. Campbell,Wendy M. Kohrt,Robert S. Schwartz,Todd T. Brown,Catherine M. Jankowski +9 more
TL;DR: Both moderate-intensity and high-intensity exercise resulted in significant improvements in physical function; high- intensity exercise may impart greater strength benefits to PLWH.
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Frailty Is an Independent Risk Factor for Mortality, Cardiovascular Disease, Bone Disease, and Diabetes Among Aging Adults With Human Immunodeficiency Virus.
Sean G. Kelly,Kunling Wu,Katherine Tassiopoulos,Kristine M. Erlandson,Susan L. Koletar,Frank J. Palella +5 more
TL;DR: Baseline frailty was associated with multiple adverse health outcomes (incident CVD, DM and bone disease), while increase in frailty score was associated without trend towards a significant association with incident bone events among PWH engaged in care.
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Effects of exercise on depression and anxiety in persons living with HIV: A meta-analysis
Andreas Heissel,Philipp Zech,Michael A. Rapp,Felipe Barreto Schuch,Jimmy B. Lawrence,Maria Kangas,Stephan Heinzel +6 more
TL;DR: Exercise seems to decrease depressive symptoms and anxiety in PLWH, but other larger and high-quality studies are needed to verify these effects.
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Expert Panel Review on Nonalcoholic Fatty Liver Disease in Persons With Human Immunodeficiency Virus
Jordan E. Lake,Turner Overton,Susanna Naggie,Mark S. Sulkowski,Rohit Loomba,David E. Kleiner,Jennifer C. Price,Kara W. Chew,Raymond T. Chung,Kathleen E. Corey +9 more
TL;DR: Current data on and knowledge gaps in the epidemiology, pathophysiology, diagnosis and management of NAFLD in PWH are reviewed and priorities for research are highlighted.
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Influence of Physical Exercise on Advanced Glycation End Products Levels in Patients Living With the Human Immunodeficiency Virus.
Karine Lino Rodrigues,Juliana Pereira Borges,Gabriella de Oliveira Lopes,Evelyn Nunes Goulart da Silva Pereira,Mauro Felippe Felix Mediano,Paulo de Tarso Veras Farinatti,Eduardo Tibiriçá,Anissa Daliry +7 more
TL;DR: HIV-infected patients under cART exhibited elevated AGEs levels compared to healthy individuals and physically active patients, and short-term aerobic training of moderate intensity counteracted this condition.
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