Journal ArticleDOI
Effects of benzodiazepine-induced sedation on temporal processing
TLDR
In a placebo-controlled study, either 15 mg of midazolam or placebo were applied to 36 healthy male volunteers to investigate the effect of pharmacologically induced sedation on temporal processing of intervals in the range of milliseconds as mentioned in this paper.Abstract:
Unlike processing of time intervals in the range of seconds or more, processing of brief durations ranging from approximately 50 to 100 ms appears to be beyond cognitive control and based on neural counting mechanisms In a placebo-controlled study either 15 mg of midazolam or placebo were applied to 36 healthy male volunteers to investigate the effect of pharmacologically induced sedation on temporal processing of intervals in the range of milliseconds indicating performance on time perception and in the range of seconds indicating performance on time estimation In addition, a test battery consisting of subtests measuring speed of information processing and cortical arousal was applied Midazolam induced a very pronounced decrease in cortical arousal as well as a marked impairment of speed of information processing and performance on time estimation as compared to placebo Performance on time perception, however, was not affected suggesting that temporal processing of very brief intervals is unrelated to the effective level of cortical arousal These findings support the notion of two different timing mechanisms underlying time estimation and time perceptionread more
Citations
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Journal ArticleDOI
The neural basis of temporal processing
TL;DR: It is suggested that, given the intricate link between temporal and spatial information in most sensory and motor tasks, timing and spatial processing are intrinsic properties of neural function, and specialized timing mechanisms such as delay lines, oscillators, or a spectrum of different time constants are not required.
Journal ArticleDOI
Neuroanatomical and neurochemical substrates of timing.
TL;DR: Neural firing rates in both striatal and interconnected frontal areas vary as a function of duration, suggesting a neurophysiological mechanism for the representation of time in the brain, with the excitatory–inhibitory balance of interactions among distinct subtypes of striatal neuron serving to fine-tune temporal accuracy and precision.
Journal ArticleDOI
Neuropharmacological evidence for different timing mechanisms in humans.
TL;DR: The overall pattern of results supports the notion that temporal processing of longer intervals is mediated by working-memory functions and, therefore, any pharmacological treatment, irrespective of the neurotransmitter system involved, that produces a deterioration of working memory, may interfere with temporal processed intervals.
Journal ArticleDOI
Learning and Generalization of Auditory Temporal–Interval Discrimination in Humans
TL;DR: Data show that temporal–interval discrimination using a 100-msec standard undergoes perceptual learning, and the neural mechanisms underlying this learning are temporally, but not spectrally, specific.
Journal ArticleDOI
How do we tell time
TL;DR: In this paper, the authors focus on timing that occurs in the range of tens to hundreds of milliseconds and show that training to discriminate between two intervals generalizes to different modalities, but not different intervals.
References
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Manual for the State-Trait Anxiety Inventory
TL;DR: The STAI as mentioned in this paper is an indicator of two types of anxiety, the state and trait anxiety, and measure the severity of the overall anxiety level, which is appropriate for those who have at least a sixth grade reading level.
Journal ArticleDOI
Transformed Up‐Down Methods in Psychoacoustics
TL;DR: A broad class of up‐down methods used in psychoacoustics with due emphasis on the related problems of parameter estimation and the efficient placing of observations is described, including examples where conventional techniques are inapplicable.
Book
The Biological Basis of Personality
TL;DR: The biological basis of personality, The biological basis for personality, and the role of language in the development of personality.