Efficacy of 8 Weeks of Sofosbuvir, Velpatasvir, and Voxilaprevir in Patients With Chronic HCV Infection: 2 Phase 3 Randomized Trials
Ira M. Jacobson,Ira M. Jacobson,Eric Lawitz,Edward Gane,Bernard Willems,Peter Ruane,Ronald Nahass,Sergio Borgia,Stephen D. Shafran,Kimberly A. Workowski,Brian L. Pearlman,Robert H. Hyland,Luisa M. Stamm,Evguenia S. Svarovskaia,Hadas Dvory-Sobol,Yanni Zhu,G. Mani Subramanian,Diana M. Brainard,John G. McHutchison,Norbert Bräu,Norbert Bräu,Thomas Berg,Kosh Agarwal,Bal Raj Bhandari,M. Davis,Jordan J. Feld,Gregory J. Dore,Catherine A.M. Stedman,Alexander J. Thompson,Tarik Asselah,Stuart K. Roberts,Graham R. Foster +31 more
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TLDR
In phase 3 trials of patients with HCV infection, it was not established that sofosbuvir-velpatasvir-voxilaprevir for 8 weeks was noninferior to sofOSbuvir -velpat asvir for 12 weeks, but the 2 regimens had similar rates of SVR in patients withHCV genotype 3 and cirrhosis.About:
This article is published in Gastroenterology.The article was published on 2017-07-01 and is currently open access. It has received 193 citations till now. The article focuses on the topics: Glecaprevir & Voxilaprevir.read more
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Journal ArticleDOI
Metalloprotoporphyrin Inhibition of HCV NS3-4A Protease: Structure–Activity Relationships
Katherine Hu,Zhaowen Zhu,Zhaowen Zhu,M. Meleah Mathahs,M. Meleah Mathahs,Huy Tran,Huy Tran,Jerry C. Bommer,Charles A Testa,Warren N. Schmidt,Warren N. Schmidt +10 more
TL;DR: The findings document the versatility of MPPs as antiviral agents with an expanded sensitivity for HCV genotypes and resistance to some common viral mutations and suggest that further study of MPP structure and function will be useful for the development of new antiviralagents.
Book ChapterDOI
Discovery of Voxilaprevir (GS-9857): The Pan-Genotypic Hepatitis C Virus NS3/4A Protease Inhibitor Utilized as a Component of Vosevi®
TL;DR: Structural modifications were made that both improved metabolic stability and reduced protein adduct formation, ultimately resulting in voxilaprevir, consistent with the optimization strategy, which has proven highly effective across genotypes in Phase 3 clinical trials and hepatoxicity has not been observed.
Journal ArticleDOI
Sustained Virologic Response Rates of Sofosbuvir and Velpatasvir in Patients with Hepatitis C Genotype 3: A Meta-Analysis
Xi Ran,HuaiYi Xie,Wei Li +2 more
TL;DR: A meta-analysis showed a high SVR12 rate of sofosbuvir/VEL in GT3 patients regardless of compensated cirrhosis the status and/or a history of previous interferon-based treatments, highlighting the need for more trials investigating the effectiveness of the SOF/VEL regimen in patients with HCV subtype 3b.
References
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Journal ArticleDOI
Sofosbuvir and Velpatasvir for HCV Genotype 1, 2, 4, 5, and 6 Infection
Jordan J. Feld,Ira M. Jacobson,Christophe Hézode,Tarik Asselah,Peter Ruane,Norbert Gruener,Armand Abergel,Alessandra Mangia,Ching-Lung Lai,Henry Lik Yuen Chan,Francesco Mazzotta,Christophe Moreno,Eric M. Yoshida,Stephen D. Shafran,William J. Towner,Tram T. Tran,John McNally,Anu Osinusi,Evguenia S. Svarovskaia,Yanni Zhu,Diana M. Brainard,John G. McHutchison,Kosh Agarwal,Stefan Zeuzem +23 more
TL;DR: Once-daily sofosbuvir-velpatasvir for 12 weeks provided high rates of sustained virologic response among both previously treated and untreated patients infected with HCV genotype 1, 2, 4, 5, or 6, including those with compensated cirrhosis.
Journal ArticleDOI
Simeprevir plus sofosbuvir, with or without ribavirin, to treat chronic infection with hepatitis C virus genotype 1 in non-responders to pegylated interferon and ribavirin and treatment-naive patients: the COSMOS randomised study
Eric Lawitz,Mark S. Sulkowski,Reem Ghalib,Maribel Rodriguez-Torres,Zobair M. Younossi,Ana Corregidor,Edwin DeJesus,Brian L. Pearlman,Mordechai Rabinovitz,Norman Gitlin,Joseph K. Lim,Paul J. Pockros,John D. Scott,Bart Fevery,Tom Lambrecht,Sivi Ouwerkerk-Mahadevan,Katleen Callewaert,William T. Symonds,Gaston Picchio,Karen L Lindsay,Maria Beumont,Ira M. Jacobson +21 more
TL;DR: Combined simeprevir and sofosbuvir was efficacious and well tolerated in chronic HCV genotype 1 infections and sustained virological response 12 weeks after stopping treatment was achieved.
Journal ArticleDOI
Sofosbuvir and Velpatasvir for HCV Genotype 2 and 3 Infection
Graham R. Foster,Nezam H. Afdhal,Stuart K. Roberts,Norbert Bräu,E.J. Gane,S. Pianko,E.J. Lawitz,Alexander J. Thompson,Mitchell L. Shiffman,Curtis L Cooper,William J. Towner,Brian Conway,Peter Ruane,M. Bourliere,Tarik Asselah,Thomas Berg,S. Zeuzem,William Rosenberg,Kosh Agarwal,Catherine A.M. Stedman,Hongmei Mo,Hadas Dvory-Sobol,Lingling Han,Jing Wang,John McNally,Anu Osinusi,Diana M. Brainard,John G. McHutchison,Francesco Mazzotta,Tram T. Tran,Stuart C. Gordon,Keyur Patel,Nancy Reau,Alessandra Mangia,Mark S. Sulkowski +34 more
TL;DR: Among patients with HCV genotype 2 or 3 with or without previous treatment, including those with compensated cirrhosis, 12 weeks of treatment with sofosbuvir-velpatasvir resulted in rates of sustained virologic response that were superior to those with standard treatment withSofosBuvir-ribavirin.
Journal ArticleDOI
Sofosbuvir, velpatasvir, and voxilaprevir for previously treated HCV infection
Marc Bourlière,Stuart C. Gordon,Steven L. Flamm,Curtis Cooper,Alnoor Ramji,Myron J. Tong,Natarajan Ravendhran,John M. Vierling,Tram T. Tran,S. Pianko,Meena B. Bansal,Victor de Ledinghen,Robert H. Hyland,Luisa M. Stamm,Hadas Dvory-Sobol,Evguenia S. Svarovskaia,Jie Zhang,K.C. Huang,G. Mani Subramanian,Diana M. Brainard,John G. McHutchison,Elizabeth C. Verna,Peter Buggisch,Charles S. Landis,Ziad Younes,Michael P. Curry,Simone I. Strasser,Eugene R. Schiff,K. Rajender Reddy,Michael P. Manns,Kris V. Kowdley,Stefan Zeuzem +31 more
TL;DR: Sofosbuvir‐velpatasvir‐voxilaprevir taken for 12 weeks provided high rates of sustained virologic response among patients across HCV genotypes in whom treatment with a DAA regimen had previously failed.
Journal ArticleDOI
Direct-acting antivirals for the treatment of hepatitis C virus infection: optimizing current IFN-free treatment and future perspectives.
TL;DR: Results obtained with oral DAA combinations that have been approved and/or have completed phase 3 clinical trials for HCV infection are summarized and future perspectives are discussed.
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