Efficacy of 8 Weeks of Sofosbuvir, Velpatasvir, and Voxilaprevir in Patients With Chronic HCV Infection: 2 Phase 3 Randomized Trials
Ira M. Jacobson,Ira M. Jacobson,Eric Lawitz,Edward Gane,Bernard Willems,Peter Ruane,Ronald Nahass,Sergio Borgia,Stephen D. Shafran,Kimberly A. Workowski,Brian L. Pearlman,Robert H. Hyland,Luisa M. Stamm,Evguenia S. Svarovskaia,Hadas Dvory-Sobol,Yanni Zhu,G. Mani Subramanian,Diana M. Brainard,John G. McHutchison,Norbert Bräu,Norbert Bräu,Thomas Berg,Kosh Agarwal,Bal Raj Bhandari,M. Davis,Jordan J. Feld,Gregory J. Dore,Catherine A.M. Stedman,Alexander J. Thompson,Tarik Asselah,Stuart K. Roberts,Graham R. Foster +31 more
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TLDR
In phase 3 trials of patients with HCV infection, it was not established that sofosbuvir-velpatasvir-voxilaprevir for 8 weeks was noninferior to sofOSbuvir -velpat asvir for 12 weeks, but the 2 regimens had similar rates of SVR in patients withHCV genotype 3 and cirrhosis.About:
This article is published in Gastroenterology.The article was published on 2017-07-01 and is currently open access. It has received 193 citations till now. The article focuses on the topics: Glecaprevir & Voxilaprevir.read more
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Pharmacokinetics and drug interactions of medications used to treat hepatitis C virus infection in the setting of chronic kidney disease and kidney transplantation
TL;DR: This review provides an overview of the essential pharmacokinetics and drug interactions of relevant antiviral therapies in the treatment of chronic hepatitis C in patients with advanced kidney disease and after kidney transplantation.
Journal ArticleDOI
Real-world effectiveness and safety of direct-acting antivirals in patients with cirrhosis and history of hepatic decompensation: Epi-Ter2 Study
Aleksandra Berkan-Kawińska,Anna Piekarska,Ewa Janczewska,Beata Lorenc,Magdalena Tudrujek-Zdunek,Krzysztof Tomasiewicz,Hanna Berak,Andrzej Horban,Dorota Zarębska-Michaluk,Paweł Pabjan,Iwona Buczyńska,Monika Pazgan-Simon,Dorota Dybowska,Waldemar Halota,Małgorzata Pawłowska,Jakub Klapaczyński,Włodzimierz Mazur,Agnieszka Czauż-Andrzejuk,Łukasz Socha,Łukasz Laurans,Aleksander Garlicki,Marek Sitko,Jerzy Jaroszewicz,Jolanta Citko,Beata Dobracka,Rafał Krygier,Jolanta Białkowska-Warzecha,Olga Tronina,Teresa Belica-Wdowik,Barbara Baka-Ćwierz,Robert Flisiak +30 more
TL;DR: In this article, the authors evaluated the real-life effectiveness and safety of direct acting antivirals (DAAs) in patients with cirrhosis and history of hepatic decompensation compared to those with compensated liver decompensation.
Journal ArticleDOI
Effectiveness and Safety of Sofosbuvir/Velpatasvir/Voxilaprevir as a Hepatitis C Virus Infection Salvage Therapy in the Real World: A Systematic Review and Meta-analysis
TL;DR: In this paper , the authors performed a systematic review and meta-analysis to assess the real world effectiveness and safety of SOF/VEL/VOX, which is the first direct-acting antiviral (DAA) therapy for patients who have previously failed a DAA-containing regimen including NS5A inhibitors.
Journal ArticleDOI
Are there any challenges left in hepatitis C virus therapy of HIV-infected patients?
TL;DR: The present review gives a concise summary of the remaining challenges in HCV treatment of HIV-positive individuals as well as an equalisation of treatment recommendations for HCV monoinfected and HIV/HCV coinfected patients.
Journal ArticleDOI
JNJ-4178 (AL-335, Odalasvir, and Simeprevir) for 6 or 8 Weeks in Hepatitis C Virus-Infected Patients Without Cirrhosis: OMEGA-1.
Stefan Zeuzem,Suzanne Bourgeois,Susan Greenbloom,Maria Buti,Alessio Aghemo,Pietro Lampertico,Ewa Janczewska,Seng Gee Lim,Christophe Moreno,Peter Buggisch,Edward Tam,Chris Corbett,Wouter Willems,Leen Vijgen,Bart Fevery,Sivi Ouwerkerk-Mahadevan,Oliver Ackaert,Maria Beumont,R. Kalmeijer,Rekha Sinha,Michael Biermer +20 more
TL;DR: The combination of three direct‐acting antiviral agents (AL‐335, odalasvir, and simeprevir: JNJ‐4178 regimen) for 6 or 8 weeks demonstrated good efficacy and safety in a phase IIa study in chronic hepatitis C virus patients without cirrhosis and has now been evaluated in a larger phase IIb study, OMEGA‐1.
References
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Journal ArticleDOI
Sofosbuvir and Velpatasvir for HCV Genotype 1, 2, 4, 5, and 6 Infection
Jordan J. Feld,Ira M. Jacobson,Christophe Hézode,Tarik Asselah,Peter Ruane,Norbert Gruener,Armand Abergel,Alessandra Mangia,Ching-Lung Lai,Henry Lik Yuen Chan,Francesco Mazzotta,Christophe Moreno,Eric M. Yoshida,Stephen D. Shafran,William J. Towner,Tram T. Tran,John McNally,Anu Osinusi,Evguenia S. Svarovskaia,Yanni Zhu,Diana M. Brainard,John G. McHutchison,Kosh Agarwal,Stefan Zeuzem +23 more
TL;DR: Once-daily sofosbuvir-velpatasvir for 12 weeks provided high rates of sustained virologic response among both previously treated and untreated patients infected with HCV genotype 1, 2, 4, 5, or 6, including those with compensated cirrhosis.
Journal ArticleDOI
Simeprevir plus sofosbuvir, with or without ribavirin, to treat chronic infection with hepatitis C virus genotype 1 in non-responders to pegylated interferon and ribavirin and treatment-naive patients: the COSMOS randomised study
Eric Lawitz,Mark S. Sulkowski,Reem Ghalib,Maribel Rodriguez-Torres,Zobair M. Younossi,Ana Corregidor,Edwin DeJesus,Brian L. Pearlman,Mordechai Rabinovitz,Norman Gitlin,Joseph K. Lim,Paul J. Pockros,John D. Scott,Bart Fevery,Tom Lambrecht,Sivi Ouwerkerk-Mahadevan,Katleen Callewaert,William T. Symonds,Gaston Picchio,Karen L Lindsay,Maria Beumont,Ira M. Jacobson +21 more
TL;DR: Combined simeprevir and sofosbuvir was efficacious and well tolerated in chronic HCV genotype 1 infections and sustained virological response 12 weeks after stopping treatment was achieved.
Journal ArticleDOI
Sofosbuvir and Velpatasvir for HCV Genotype 2 and 3 Infection
Graham R. Foster,Nezam H. Afdhal,Stuart K. Roberts,Norbert Bräu,E.J. Gane,S. Pianko,E.J. Lawitz,Alexander J. Thompson,Mitchell L. Shiffman,Curtis L Cooper,William J. Towner,Brian Conway,Peter Ruane,M. Bourliere,Tarik Asselah,Thomas Berg,S. Zeuzem,William Rosenberg,Kosh Agarwal,Catherine A.M. Stedman,Hongmei Mo,Hadas Dvory-Sobol,Lingling Han,Jing Wang,John McNally,Anu Osinusi,Diana M. Brainard,John G. McHutchison,Francesco Mazzotta,Tram T. Tran,Stuart C. Gordon,Keyur Patel,Nancy Reau,Alessandra Mangia,Mark S. Sulkowski +34 more
TL;DR: Among patients with HCV genotype 2 or 3 with or without previous treatment, including those with compensated cirrhosis, 12 weeks of treatment with sofosbuvir-velpatasvir resulted in rates of sustained virologic response that were superior to those with standard treatment withSofosBuvir-ribavirin.
Journal ArticleDOI
Sofosbuvir, velpatasvir, and voxilaprevir for previously treated HCV infection
Marc Bourlière,Stuart C. Gordon,Steven L. Flamm,Curtis Cooper,Alnoor Ramji,Myron J. Tong,Natarajan Ravendhran,John M. Vierling,Tram T. Tran,S. Pianko,Meena B. Bansal,Victor de Ledinghen,Robert H. Hyland,Luisa M. Stamm,Hadas Dvory-Sobol,Evguenia S. Svarovskaia,Jie Zhang,K.C. Huang,G. Mani Subramanian,Diana M. Brainard,John G. McHutchison,Elizabeth C. Verna,Peter Buggisch,Charles S. Landis,Ziad Younes,Michael P. Curry,Simone I. Strasser,Eugene R. Schiff,K. Rajender Reddy,Michael P. Manns,Kris V. Kowdley,Stefan Zeuzem +31 more
TL;DR: Sofosbuvir‐velpatasvir‐voxilaprevir taken for 12 weeks provided high rates of sustained virologic response among patients across HCV genotypes in whom treatment with a DAA regimen had previously failed.
Journal ArticleDOI
Direct-acting antivirals for the treatment of hepatitis C virus infection: optimizing current IFN-free treatment and future perspectives.
TL;DR: Results obtained with oral DAA combinations that have been approved and/or have completed phase 3 clinical trials for HCV infection are summarized and future perspectives are discussed.
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