Efficacy of 8 Weeks of Sofosbuvir, Velpatasvir, and Voxilaprevir in Patients With Chronic HCV Infection: 2 Phase 3 Randomized Trials
Ira M. Jacobson,Ira M. Jacobson,Eric Lawitz,Edward Gane,Bernard Willems,Peter Ruane,Ronald Nahass,Sergio Borgia,Stephen D. Shafran,Kimberly A. Workowski,Brian L. Pearlman,Robert H. Hyland,Luisa M. Stamm,Evguenia S. Svarovskaia,Hadas Dvory-Sobol,Yanni Zhu,G. Mani Subramanian,Diana M. Brainard,John G. McHutchison,Norbert Bräu,Norbert Bräu,Thomas Berg,Kosh Agarwal,Bal Raj Bhandari,M. Davis,Jordan J. Feld,Gregory J. Dore,Catherine A.M. Stedman,Alexander J. Thompson,Tarik Asselah,Stuart K. Roberts,Graham R. Foster +31 more
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TLDR
In phase 3 trials of patients with HCV infection, it was not established that sofosbuvir-velpatasvir-voxilaprevir for 8 weeks was noninferior to sofOSbuvir -velpat asvir for 12 weeks, but the 2 regimens had similar rates of SVR in patients withHCV genotype 3 and cirrhosis.About:
This article is published in Gastroenterology.The article was published on 2017-07-01 and is currently open access. It has received 193 citations till now. The article focuses on the topics: Glecaprevir & Voxilaprevir.read more
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Journal ArticleDOI
Daclatasvir and sofosbuvir with ribavirin for 24 weeks in chronic hepatitis C genotype-3-infected patients with cirrhosis: a Phase III study (ALLY-3C).
Fred Poordad,Mitchell L. Shiffman,Wayne Ghesquiere,Alexander Wong,Gregory D Huhn,Florence Wong,Alnoor Ramji,Stephen D. Shafran,Fiona McPhee,Rong Yang,Stephanie Noviello,Misti Linaberry +11 more
TL;DR: Daclatasvir+sofosbuvir+ribavirin for 24 weeks was well tolerated and efficacious in HCV genotype-3-infected patients with compensated cirrhosis, with SVR12 outcomes comparable to previously reported outcomes in patients treated with this regimen for 12-16 weeks.
Journal ArticleDOI
Phase 3, Multicenter Open‐Label study to investigate the efficacy of elbasvir and grazoprevir fixed‐dose combination for 8 weeks in treatment‐naïve, HCV GT1b‐infected patients, with non‐severe fibrosis
Armand Abergel,Tarik Asselah,A. Mallat,Brigitte Chanteranne,Frederic Faure,Dominique Larrey,J. Gournay,Véronique Loustaud-Ratti,Vincent Di Martino,Isabelle Fouchard-Hubert,Stanislas Pol,François Bailly,Didier Samuel,Albert Tran,Marie Dodel,Nicolas Andant,Géraldine Lamblin,Leon Muti,Maud Reymond,Camille Teilhet,Bruno Pereira,Benjamin Buchard +21 more
TL;DR: Evaluated the efficacy of 8 weeks fixed‐dose combination of grazoprevir‐elbasvir in treatment‐naïve patients, with non‐severe fibrosis, in order to improve adherence, reduce drug exposure and cost.
Journal ArticleDOI
Spectroscopic study of self-assembly of anti-hepatitis C virus sofosbuvir drug with bio-polymeric nanoparticles for improving the drug release effect.
TL;DR: In this article, the authors investigated self-assembly of Sofosbuvir drug (SOF) anti-hepatitis C virus (HCV) with bio-polymeric nanoparticles such as chitosan nanoparticles and polyvinyl alcohol nanoparticles (PVA NPs).
Journal ArticleDOI
Efficacy and Safety Results of Patients with HCV Genotype 2 or 3 Infection Treated with Ombitasvir/Paritaprevir/ritonavir and Sofosbuvir with or without Ribavirin (QUARTZ II-III).
Stephen D. Shafran,David R. Shaw,Mariem Charafeddine,Kosh Agarwal,Graham R. Foster,Manal Abunimeh,Tami Pilot-Matias,Rajvineeth Kumar Pothacamury,Bo Fu,Eric Cohen,Daniel E. Cohen,Edward Gane +11 more
TL;DR: The investigational combination of OBV/PTV/r with SOF ± RBV was well tolerated and achieved high SVR rates with no virologic failures in patients with genotype 3 infection.
Journal ArticleDOI
Profile of sofosbuvir/velpatasvir/voxilaprevir in the treatment of hepatitis C.
TL;DR: Treatment with sofosbuvir/velpatasvir/voxilaprevir is well tolerated, with the most commonly reported adverse events being headache, fatigue, diarrhea, and nausea.
References
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Journal ArticleDOI
Sofosbuvir and Velpatasvir for HCV Genotype 1, 2, 4, 5, and 6 Infection
Jordan J. Feld,Ira M. Jacobson,Christophe Hézode,Tarik Asselah,Peter Ruane,Norbert Gruener,Armand Abergel,Alessandra Mangia,Ching-Lung Lai,Henry Lik Yuen Chan,Francesco Mazzotta,Christophe Moreno,Eric M. Yoshida,Stephen D. Shafran,William J. Towner,Tram T. Tran,John McNally,Anu Osinusi,Evguenia S. Svarovskaia,Yanni Zhu,Diana M. Brainard,John G. McHutchison,Kosh Agarwal,Stefan Zeuzem +23 more
TL;DR: Once-daily sofosbuvir-velpatasvir for 12 weeks provided high rates of sustained virologic response among both previously treated and untreated patients infected with HCV genotype 1, 2, 4, 5, or 6, including those with compensated cirrhosis.
Journal ArticleDOI
Simeprevir plus sofosbuvir, with or without ribavirin, to treat chronic infection with hepatitis C virus genotype 1 in non-responders to pegylated interferon and ribavirin and treatment-naive patients: the COSMOS randomised study
Eric Lawitz,Mark S. Sulkowski,Reem Ghalib,Maribel Rodriguez-Torres,Zobair M. Younossi,Ana Corregidor,Edwin DeJesus,Brian L. Pearlman,Mordechai Rabinovitz,Norman Gitlin,Joseph K. Lim,Paul J. Pockros,John D. Scott,Bart Fevery,Tom Lambrecht,Sivi Ouwerkerk-Mahadevan,Katleen Callewaert,William T. Symonds,Gaston Picchio,Karen L Lindsay,Maria Beumont,Ira M. Jacobson +21 more
TL;DR: Combined simeprevir and sofosbuvir was efficacious and well tolerated in chronic HCV genotype 1 infections and sustained virological response 12 weeks after stopping treatment was achieved.
Journal ArticleDOI
Sofosbuvir and Velpatasvir for HCV Genotype 2 and 3 Infection
Graham R. Foster,Nezam H. Afdhal,Stuart K. Roberts,Norbert Bräu,E.J. Gane,S. Pianko,E.J. Lawitz,Alexander J. Thompson,Mitchell L. Shiffman,Curtis L Cooper,William J. Towner,Brian Conway,Peter Ruane,M. Bourliere,Tarik Asselah,Thomas Berg,S. Zeuzem,William Rosenberg,Kosh Agarwal,Catherine A.M. Stedman,Hongmei Mo,Hadas Dvory-Sobol,Lingling Han,Jing Wang,John McNally,Anu Osinusi,Diana M. Brainard,John G. McHutchison,Francesco Mazzotta,Tram T. Tran,Stuart C. Gordon,Keyur Patel,Nancy Reau,Alessandra Mangia,Mark S. Sulkowski +34 more
TL;DR: Among patients with HCV genotype 2 or 3 with or without previous treatment, including those with compensated cirrhosis, 12 weeks of treatment with sofosbuvir-velpatasvir resulted in rates of sustained virologic response that were superior to those with standard treatment withSofosBuvir-ribavirin.
Journal ArticleDOI
Sofosbuvir, velpatasvir, and voxilaprevir for previously treated HCV infection
Marc Bourlière,Stuart C. Gordon,Steven L. Flamm,Curtis Cooper,Alnoor Ramji,Myron J. Tong,Natarajan Ravendhran,John M. Vierling,Tram T. Tran,S. Pianko,Meena B. Bansal,Victor de Ledinghen,Robert H. Hyland,Luisa M. Stamm,Hadas Dvory-Sobol,Evguenia S. Svarovskaia,Jie Zhang,K.C. Huang,G. Mani Subramanian,Diana M. Brainard,John G. McHutchison,Elizabeth C. Verna,Peter Buggisch,Charles S. Landis,Ziad Younes,Michael P. Curry,Simone I. Strasser,Eugene R. Schiff,K. Rajender Reddy,Michael P. Manns,Kris V. Kowdley,Stefan Zeuzem +31 more
TL;DR: Sofosbuvir‐velpatasvir‐voxilaprevir taken for 12 weeks provided high rates of sustained virologic response among patients across HCV genotypes in whom treatment with a DAA regimen had previously failed.
Journal ArticleDOI
Direct-acting antivirals for the treatment of hepatitis C virus infection: optimizing current IFN-free treatment and future perspectives.
TL;DR: Results obtained with oral DAA combinations that have been approved and/or have completed phase 3 clinical trials for HCV infection are summarized and future perspectives are discussed.
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