Elevated cerebrospinal fluid and blood concentrations of oxytocin following its intranasal administration in humans
Nadine Striepens,Keith M. Kendrick,Vanessa Hanking,Rainer Landgraf,Ullrich Wüllner,Wolfgang Maier,Wolfgang Maier,René Hurlemann +7 more
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TLDR
Combined blood and cerebrospinal fluid sampling in subjects receiving either 24 IU of oxytocin or placebo is shown to show that oxytocIn levels significantly increased in both plasma and CSF, however, whereas Oxytocin plasma concentrations peaked at 15 min after intranasal administration and decreased after 75’�min, CSF concentrations took up to 75”min to reach a significant level.Abstract:
There has been an unprecedented interest in the modulatory effects of intranasal oxytocin on human social cognition and behaviour, however as yet no study has actually demonstrated that this modality of administration increases concentrations of the peptide in the brain as well as blood in humans. Here using combined blood and cerebrospinal fluid (CSF) sampling in subjects receiving either 24 IU of oxytocin (n = 11) or placebo (n = 4) we have shown that oxytocin levels significantly increased in both plasma and CSF. However, whereas oxytocin plasma concentrations peaked at 15 min after intranasal administration and decreased after 75 min, CSF concentrations took up to 75 min to reach a significant level. Moreover, there was no correlation (r = <0.10) between oxytocin plasma and CSF concentrations. Together, these data provide crucial insights into the plasma and CSF kinetics of intranasally administered oxytocin.read more
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Intranasal Oxytocin: Myths and Delusions
Gareth Leng,Mike Ludwig +1 more
TL;DR: Effects of intranasal oxytocin also need proper dose-response studies, and such studies need to include control subjects for peripheral effects, by administering Oxytocin peripherally and by blocking peripheral actions with antagonists.
Journal ArticleDOI
The biology of mammalian parenting and its effect on offspring social development
James K. Rilling,Larry J. Young +1 more
TL;DR: The biological mechanisms governing this shift in parental motivation in mammals, where giving birth leads from an aversion to infant stimuli to irresistible attraction is reviewed, are reviewed.
Journal ArticleDOI
Oxytocin by intranasal and intravenous routes reaches the cerebrospinal fluid in rhesus macaques: determination using a novel oxytocin assay
Mary R. Lee,Karl B. Scheidweiler,Xingxing Diao,Fatemeh Akhlaghi,Alex Cummins,Marilyn A. Huestis,Lorenzo Leggio,Lorenzo Leggio,Bruno B. Averbeck +8 more
TL;DR: CSF penetrance of d5, exogenous OT delivered by IN and IV administration is demonstrated and suggests that peripheral administration of OT does not lead to central release of endogenous OT, and that IN administration offered an advantage compared to IV administration with respect to achieving greater CSF concentrations of OT.
Journal ArticleDOI
Does Oxytocin Increase Trust in Humans? A Critical Review of Research
TL;DR: It is concluded that the cumulative evidence does not provide robust convergent evidence that human trust is reliably associated with OT (or caused by it) and constructive ideas for improving the robustness and rigor of OT research are presented.
Journal ArticleDOI
Kinetics and Dose Dependency of Intranasal Oxytocin Effects on Amygdala Reactivity
Franny B Spengler,Johannes Schultz,Dirk Scheele,Maximiliane Essel,Wolfgang A. Maier,Markus Heinrichs,René Hurlemann +6 more
TL;DR: These findings provide initial evidence of the most effective dose and dose-test interval for future experimental or therapeutic regimens aimed at targeting amygdala functioning using intranasal OXT administration.
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