Journal ArticleDOI
Endotoxemic-like shock induced by Loxosceles spider venoms: pathological changes and putative cytokine mediators
Denise V. Tambourgi,Vera L. Petricevich,Fábio Carlos Magnoli,Suely Lucia Muro Rais Assaf,Sonia Jancar,W. Dias da Silva +5 more
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TLDR
It is indicated that the state of shock produced in mice by whole endotoxin-free L. intermedia venom or by its purified fraction, protein F35, mimics the endotoxemic shock, that susceptibility to the systemic effects of the venom varies among mice of different haplotypes and that the pattern of in vivo cytokine release resembles that of endotoxical shock.About:
This article is published in Toxicon.The article was published on 1998-03-26. It has received 70 citations till now. The article focuses on the topics: Antivenom & Venom.read more
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Journal ArticleDOI
Phospholipase D - enzymology, functionality, and chemical modulation
TL;DR: In this comprehensive review of the PLD superfamily, specific emphasis is given to the conventional mammalian isoforms, PLD1 and PLD2, and the tools with which these enzymes are studied.
Journal ArticleDOI
Brown spiders and loxoscelism
Paulo Henrique da Silva,Rafael Bertoni da Silveira,Marcia Helena Appel,Oldemir C. Mangili,Waldemiro Gremski,Silvio Sanches Veiga +5 more
TL;DR: The biology and epidemiology of the brown spider, the histopathology of envenomation and the immunogenicity of Loxosceles venom are reviewed, as are the clinical features, diagnosis and therapy of brown spider bites.
Journal ArticleDOI
Pathogenesis of Malaria and Clinically Similar Conditions
TL;DR: The pathogenesis of the disease caused by falciparum malaria is considered in the light of what has been learned about the roles of these mediators in these other diseases, as well as in malaria itself.
Journal ArticleDOI
Sphingomyelinases in the venom of the spider Loxosceles intermedia are responsible for both dermonecrosis and complement-dependent hemolysis
Denise V. Tambourgi,Fábio Carlos Magnoli,Carmen W. van den Berg,B. Paul Morgan,Pedro Soares De Araujo,Elias W. Alves,W. Dias da Silva +6 more
TL;DR: Functional characterisation of P1 and P2 indicated the presence of sphingomyelinase activity and either protein in isolation was capable of inducing all the in vivo effects seen with whole spider venom, including C-dependent haemolysis and dermonecrosis.
Journal ArticleDOI
Increments in serum cytokine and nitric oxide levels in mice injected with Bothrops asper and Bothrops jararaca snake venoms
TL;DR: A complex pattern of cytokine and nitric oxide synthesis and secretion occurs in severe experimental envenomation by B. asper and B. jararaca venoms, and it is suggested that some of these mediators might play a relevant role in the pathophysiology of systemic alterations induced by these venoms.
References
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Interleukin 10(IL-10) inhibits cytokine synthesis by human monocytes: an autoregulatory role of IL-10 produced by monocytes.
TL;DR: The results indicate that IL-10 has important regulatory effects on immunological and inflammatory responses because of its capacity to downregulate class II MHC expression and to inhibit the production of proinflammatory cytokines by monocytes.
Journal Article
IL-10 inhibits cytokine production by activated macrophages.
TL;DR: The potent action of IL-10 on the macrophage, particularly at the level of monokine production, supports an important role for this cytokine not only in the regulation of T cell responses but also in acute inflammatory responses.
Journal ArticleDOI
The biology of cachectin/TNF--a primary mediator of the host response
Bruce Beutler,Anthony Cerami +1 more
TL;DR: A limited number of cytokines are capable of orches trating disease states that scarcely resemble one another; among them, endotoxic shock, graft-vs-host disease, cerebral malaria, and cancer cachexia.
Book ChapterDOI
Interleukin-6 in biology and medicine
TL;DR: Application of IL-6 is promising in cancer treatment as well as in treatment of radiation- or chemotherapy-induced myelosuppression and the cell biology of the intracellular events that link transduction to gene regulation is an important area, and work on these topics helps to understand such phenomena as multifunction of IL -6 and bidirectional effects of cell growth depending on the cell type.
Journal ArticleDOI
Endotoxins and disease mechanisms
D C Morrison,J L Ryan +1 more
TL;DR: In this chapter, current concepts about the mechanisms of action of endotoxin are reviewed and particular attention is focused upon endotoxin-induced production of soluble mediators from macrophages and mononuclear cells and on the potential contribution of these mediators to endotoxin shock.