Environmental pollutants, a possible etiology for premature ovarian insufficiency: a narrative review of animal and human data
Pauline Vabre,N. Gatimel,Jessika Moreau,Véronique Gayrard,Nicole Picard-Hagen,Jean Parinaud,Roger Leandri +6 more
TLDR
Environmental pollutants are probably a cause of premature ovarian insufficiency with an increased follicular depletion leading to an earlier age of menopause onset and the main mechanism seemed to be an increase in atresia of pre-antral follicles.Abstract:
Because only 25% of cases of premature ovarian insufficiency (POI) have a known etiology, the aim of this review was to summarize the associations and mechanisms of the impact of the environment on this pathology. Eligible studies were selected from an electronic literature search from the PUBMED database from January 2000 to February 2016 and associated references in published studies. Search terms included ovary, follicle, oocyte, endocrine disruptor, environmental exposure, occupational exposure, environmental contaminant, pesticide, polyaromatic hydrocarbon, polychlorinated biphenyl PCB, phenol, bisphenol, flame retardant, phthalate, dioxin, phytoestrogen, tobacco, smoke, cigarette, cosmetic, xenobiotic. The literature search was conducted in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. We have included the human and animal studies corresponding to the terms and published in English. We have excluded articles that included results that did not concern ovarian pathology and those focused on ovarian cancer, polycystic ovary syndrome, endometriosis or precocious puberty. We have also excluded genetic, auto-immune or iatrogenic causes from our analysis. Finally, we have excluded animal data that does not concern mammals and studies based on results from in vitro culture. Data have been grouped according to the studied pollutants in order to synthetize their impact on follicular development and follicular atresia and the molecular pathways involved. Ninety-seven studies appeared to be eligible and were included in the present study, even though few directly address POI. Phthalates, bisphenol A, pesticides and tobacco were the most reported substances having a negative impact on ovarian function with an increased follicular depletion leading to an earlier age of menopause onset. These effects were found when exposure occured at different times throughout the lifetime from the prenatal to the adult period, possibly due to different mechanisms. The main mechanism seemed to be an increase in atresia of pre-antral follicles. Environmental pollutants are probably a cause of POI. Health officials and the general public must be aware of this environmental effect in order to implement individual and global preventive actions.read more
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Road traffic noise effects on cardiovascular, respiratory, and metabolic health: An integrative model of biological mechanisms.
TL;DR: A comprehensive, integrative stress model is presented with all known connections between the body systems, states, and processes at both the physiological and psychological levels, which allows to establish a variety of biological pathways linking environmental noise exposure with health outcomes.
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Forty years of IVF
Craig Niederberger,Antonio Pellicer,Jacques Cohen,David K. Gardner,Gianpiero D. Palermo,C. O'Neill,S. Chow,Zev Rosenwaks,Ana Cobo,Jason E. Swain,William B. Schoolcraft,René Frydman,L.A. Bishop,Davora Aharon,Catherine M. Gordon,Erika New,Alan H. DeCherney,Seang Lin Tan,Richard J. Paulson,James M. Goldfarb,Mats Brännström,Jacques Donnez,Sherman J. Silber,Marie-Madeleine Dolmans,Marie-Madeleine Dolmans,Joe Leigh Simpson,Alan H. Handyside,Santiago Munné,Cristina Eguizabal,Nuria Montserrat,Juan Carlos Izpisua Belmonte,Alan O Trounson,Carlos Simón,Togas Tulandi,Linda C. Giudice,Robert J. Norman,Aaron J. W. Hsueh,Yingpu Sun,Neri Laufer,Ronit Kochman,Talia Eldar-Geva,Bruno Lunenfeld,Diego Ezcurra,Thomas D'Hooghe,Thomas D'Hooghe,Thomas D'Hooghe,Bart C.J.M. Fauser,Basil C. Tarlatzis,David R. Meldrum,Robert F. Casper,Human M. Fatemi,Paul Devroey,Daniela Galliano,Matts Wikland,Mark Sigman,Richard A. Schoor,Marc Goldstein,Larry I. Lipshultz,Peter N. Schlegel,Alayman Hussein,Robert D. Oates,Robert E. Brannigan,Heather E. Ross,Guido Pennings,Susan C. Klock,Simon Brown,Andre Van Steirteghem,Robert W. Rebar,Robert W. Rebar,Andrew R. LaBarbera,Andrew R. LaBarbera,Andrew R. LaBarbera +71 more
TL;DR: This monograph, written by the pioneers of IVF and reproductive medicine, celebrates the history, achievements, and medical advancements made over the last 40 years in this rapidly growing field.
Journal ArticleDOI
Perfluoroalkyl and polyfluoroalkyl substances (PFAS) and their effects on the ovary.
TL;DR: The published literature supports associations between PFAS exposure and adverse reproductive outcomes; however, the evidence remains insufficient to infer a causal relationship between PFAs exposure and ovarian disorders.
Journal ArticleDOI
Advances in the Molecular Pathophysiology, Genetics, and Treatment of Primary Ovarian Insufficiency
Ilpo Huhtaniemi,Outi Hovatta,Antonio La Marca,Gabriel Livera,Danielle Monniaux,Luca Persani,Abdelkader Heddar,Katarzyna Jarzabek,Triin Laisk-Podar,Andres Salumets,Juha S. Tapanainen,Juha S. Tapanainen,Reiner A. Veitia,Jenny A. Visser,Peter Wieacker,Slawomir Wolczynski,Micheline Misrahi +16 more
TL;DR: NGS will provide a genetic diagnosis leading to genetic/therapeutic counseling: first, defects in meiosis or DNA repair genes may predispose to tumors; and second, specific gene defects may predict the risk of rapid loss of a persistent ovarian reserve, an important determinant in fertility preservation.
Journal ArticleDOI
Premature ovarian insufficiency: an International Menopause Society White Paper
Nicholas Panay,Richard A. Anderson,R. E. Nappi,Amanda J. Vincent,Svetlana Vujovic,L. Webber,Wendy Wolfman +6 more
TL;DR: It is hoped that a global task force will be convened in order to formulate a consensus statement across key societies, to accelerate date collection and analysis of a global POI registry, and to facilitate progress in the key defined areas of research.
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