Journal ArticleDOI
Enzymology and biosynthesis of the orsellinic acid derived medicinal meroterpenoids.
TLDR
These studies will lay the foundation for the production of meroterpenoids with novel medicinal properties and the knowledge of the biosynthetic machinery, combinatorial and engineered biosyntheses have yielded novel molecules with improved bioactivities.About:
This article is published in Current Opinion in Biotechnology.The article was published on 2021-06-01. It has received 6 citations till now. The article focuses on the topics: Orsellinic acid.read more
Citations
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Journal ArticleDOI
A series of meroterpenoids with rearranged skeletons from an endophytic fungus Penicillium sp. GDGJ-285
Tu-Xiang Mo,Xishan Huang,Wenxiu Zhang,Till F. Schäberle,Till F. Schäberle,Jiangke Qin,Dexiong Zhou,Xiao-Ya Qin,Zhao-Long Xu,Jun Li,Rui-Yun Yang +10 more
TL;DR: In this article, the skeleton meroterpenoids of the fungus Penicillium sp. GDGJ-285 were determined by X-ray single-crystal diffraction analysis.
Journal ArticleDOI
Osteoclastogenesis inhibitory phenolic derivatives produced by the Beibu Gulf coral-associated fungus Acremonium sclerotigenum GXIMD 02501.
Humu Lu,Yanhui Tan,Yanting Zhang,Zhichao Li,Jinying Chen,Cheng-Hai Gao,Yonghong Liu,Xiaowei Luo +7 more
TL;DR: In this paper , three new chlorinated orsellinic aldehyde derivatives, orsaldechlorins A -C (1-3), and a naturally new brominated ORSinic acid (7), along with ten known biosynthetically related phenolic derivatives, were identified from the Beibu Gulf coral-derived fungus Acremonium sclerotigenum GXIMD 02501.
Journal ArticleDOI
Reconstitution of Polyketide-Derived Meroterpenoid Biosynthetic Pathway in Aspergillus oryzae.
Takayoshi Awakawa,Ikuro Abe +1 more
TL;DR: In this article, a review of fungal polyketide-derived meroterpenoids, a group of bioactive natural products, by means of the A. oryzae heterologous expression system is presented.
Journal ArticleDOI
Structure-based engineering of α-ketoglutarate dependent oxygenases in fungal meroterpenoid biosynthesis.
TL;DR: This review summarizes recent progress in the structure-based engineering of αKG OX enzymes, involved in the biosynthesis of polyketide-derived fungal meroterpenoids, and the literature published from 2016 through February 2022 is reviewed.
Journal ArticleDOI
Orthoester formation in fungal meroterpenoid austalide F biosynthesis
TL;DR: In this paper , the authors presented the extraordinary orthoester biosynthetic machinery and provided valuable insights into the creation of unnatural novel bioactive meroterpenoids through engineered biosynthesis.
References
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High-level semi-synthetic production of the potent antimalarial artemisinin
Christopher J. Paddon,Patrick J. Westfall,Douglas J. Pitera,Kirsten R. Benjamin,Karl Fisher,Derek McPhee,Michael D. Leavell,Anna Tai,A. Main,Diana Eng,Devin R Polichuk,Keat H. Teoh,Darwin W. Reed,T. Treynor,Jacob R. Lenihan,Hanxiao Jiang,M. Fleck,S. Bajad,G. Dang,D. Dengrove,Don Diola,G. Dorin,Kenneth W. Ellens,Scott Fickes,J. Galazzo,Sara P. Gaucher,T. Geistlinger,Ronald Henry,M. Hepp,Tizita Horning,T. Iqbal,L. Kizer,B. Lieu,D. Melis,Nathan A. Moss,Rika Regentin,S. Secrest,H. Tsuruta,R. Vazquez,Lars F. Westblade,Lan Xu,M. Yu,Yansheng Zhang,Lishan Zhao,Jefferson C. Lievense,Patrick S. Covello,Jay D. Keasling,K. K. Reiling,N. S. Renninger,Jack D. Newman +49 more
TL;DR: The strains and processes described here form the basis of a viable industrial process for the production of semi-synthetic artemisinin to stabilize the supply of art Artemisinin for derivatization into active pharmaceutical ingredients (for example, artesunate) for incorporation into ACTs.
Journal ArticleDOI
Medicinal Natural Products: A Biosynthetic Approach
Geoffrey C. Kite,Paul M. Dewick +1 more
TL;DR: In this paper, the authors present an approach for the construction of blocks and constructions of machinery for primary and secondary metabolic systems based on the properties of the building blocks and the construction mechanism.
Journal ArticleDOI
Complete biosynthesis of opioids in yeast
Stephanie Galanie,Kate Thodey,Isis Trenchard,Maria V. Filsinger Interrante,Christina D. Smolke +4 more
TL;DR: Yeast is engineered to produce the opioid compounds thebaine and hydrocodone, starting from sugar, a proof of principle, and major hurdles remain before optimization and scale-up could be achieved.
Journal ArticleDOI
Author Correction: The nature of spin excitations in the one-third magnetization plateau phase of Ba3CoSb2O9.
Yoshitomo Kamiya,L. Ge,Tao Hong,Yiming Qiu,D. L. Quintero-Castro,Zhilun Lu,Huibo Cao,Masaaki Matsuda,E. S. Choi,Cristian D. Batista,Cristian D. Batista,Martin Mourigal,H. D. Zhou,H. D. Zhou,Jie Ma,Jie Ma +15 more
TL;DR: The original version of this Article omitted the following from the Acknowledgements: ‘J. Ma’s primary affiliation is Shanghai Jiao Tong University’.
Journal ArticleDOI
A CRISPR-Cas9 System for Genetic Engineering of Filamentous Fungi
TL;DR: A CRISPR-Cas9 based system adapted for use in filamentous fungi that performs RNA-guided mutagenesis in six species of which one has not previously been genetically engineered and demonstrates that the resulting strain can be used for iterative gene targeting.