Estrogenic Activity of Sanguiin H-6 through Activation of Estrogen Receptor α Coactivator-binding Site
Tuy An Trinh,Eun-Ji Park,Dahae Lee,Ji Hoon Song,Hye Lim Lee,Ki-Hyun Kim,Young Hoon Kim,Kiwon Jung,Ki Sung Kang,Jeong-Eun Yoo +9 more
TLDR
Phytochemicals from Rubus coreanus that were able to disrupt ERα and coactivator interaction with an ERα antagonist were investigated and indicated that sanguiin H6 contributed to the estrogenic activity of R. coreanus through the activation of the ERα coActivator-binding site.Abstract:
A popular approach for the study of estrogen receptor α inhibition is to investigate the protein-protein interaction between the estrogen receptor (ER) and the coactivator surface. In our study, we investigated phytochemicals from Rubus coreanus that were able to disrupt ERα and coactivator interaction with an ERα antagonist. The E-screen assay and molecular docking analysis were performed to evaluate the effects of the estrogenic activity of R. coreanus extract and its constituents on the MCF-7 human breast cancer cell line. At 100 μg/mL, R. coreanus extract significantly stimulated cell proliferation (574.57 ± 8.56%). Sanguiin H6, which was isolated from R. coreanus, demonstrated the strongest affinity for the ERα coactivator-binding site in molecular docking analysis, with a binding energy of -250.149. The initial results of the study indicated that sanguiin H6 contributed to the estrogenic activity of R. coreanus through the activation of the ERα coactivator-binding site.read more
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Protective Effect of Shikimic Acid against Cisplatin-Induced Renal Injury: In Vitro and In Vivo Studies
Jinkyung Lee,Quynh Nhu Nguyen,Jun Yeon Park,Sullim Lee,Gwi Seo Hwang,Noriko Yamabe,Sung-Youl Choi,Ki Sung Kang +7 more
TL;DR: This study is the first report on the nephroprotective effect of A. absinthium extract and its mechanism of action against cisplatin-induced renal injury and shikimic acid protected against kidney injury in cis platin-treated mice by reducing serum creatinine levels.
Journal ArticleDOI
Estrogenic Effects of Extracts and Isolated Compounds from Belowground and Aerial Parts of Spartina anglica.
Sullim Lee,Geum Jin Kim,Hyukbean Kwon,Joo-Won Nam,Ji Yun Baek,Sang Hee Shim,Hyukjae Choi,Ki Sung Kang +7 more
TL;DR: In this article, the estrogenic and anti-proliferative effects of extracts of SA and its compounds in MCF-7 breast cancer cells were evaluated using an immature female rat model.
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Comparative Evaluation of Apoptosis Induction Using Needles, Bark, and Pollen Extracts and Essential Oils of Pinus eldarica in Lung Cancer Cells
Tayyebeh Ghaffari,Solmaz Asnaashari,Ebrahim Irannejad,Abbas Delazar,Safar Farajnia,Joo-Hyun Hong,Changhyun Pang,Hamed Hamishehkar,Ki-Hyun Kim +8 more
TL;DR: Findings provide experimental evidence for a new therapeutic effect of P. Eldarica against human lung cancer and suggest P. eldarica as a potential chemopreventive natural resource for developing novel cancer therapeutics.
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Carthamusuchuric acid, an enolic glucoside of phenylpyruvic acid from the florets of Carthamus tinctorius and anti-adipogenic phenolic compounds
TL;DR: A new unique enolic glucoside of phenylpyruvic acid, carthamusuchuric acid, and five known phenolic compounds (2, 6) were isolated from the florets of Carthamus tinctorius as discussed by the authors.
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Identification of Bioactive Natural Product from the Stems and Stem Barks of Cornus walteri: Benzyl Salicylate Shows Potential Anti-Inflammatory Activity in Lipopolysaccharide-Stimulated RAW 264.7 Macrophages.
TL;DR: In this article, the anti-inflammatory potential of compounds from C. walteri in lipopolysaccharide (LPS)-stimulated mouse RAW 264.7 macrophages were explored.
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