Estrogenic Activity of Sanguiin H-6 through Activation of Estrogen Receptor α Coactivator-binding Site
Tuy An Trinh,Eun-Ji Park,Dahae Lee,Ji Hoon Song,Hye Lim Lee,Ki-Hyun Kim,Young Hoon Kim,Kiwon Jung,Ki Sung Kang,Jeong-Eun Yoo +9 more
TLDR
Phytochemicals from Rubus coreanus that were able to disrupt ERα and coactivator interaction with an ERα antagonist were investigated and indicated that sanguiin H6 contributed to the estrogenic activity of R. coreanus through the activation of the ERα coActivator-binding site.Abstract:
A popular approach for the study of estrogen receptor α inhibition is to investigate the protein-protein interaction between the estrogen receptor (ER) and the coactivator surface. In our study, we investigated phytochemicals from Rubus coreanus that were able to disrupt ERα and coactivator interaction with an ERα antagonist. The E-screen assay and molecular docking analysis were performed to evaluate the effects of the estrogenic activity of R. coreanus extract and its constituents on the MCF-7 human breast cancer cell line. At 100 μg/mL, R. coreanus extract significantly stimulated cell proliferation (574.57 ± 8.56%). Sanguiin H6, which was isolated from R. coreanus, demonstrated the strongest affinity for the ERα coactivator-binding site in molecular docking analysis, with a binding energy of -250.149. The initial results of the study indicated that sanguiin H6 contributed to the estrogenic activity of R. coreanus through the activation of the ERα coactivator-binding site.read more
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Ulmusakidian, a new coumarin glycoside and antifungal phenolic compounds from the root bark of Ulmus davidiana var. japonica
Akida Alishir,Jae Sik Yu,Minji Park,Jin-Chul Kim,Changhyun Pang,Jung Kyu Kim,Tae Su Jang,Won Hee Jung,Ki-Hyun Kim +8 more
TL;DR: In this article, a bioactivity-driven LC/MS-based phytochemical analysis of the root bark extract of Ulmus davidiana var. japonica led to the isolation of 10 compounds including a new coumarin glycoside derivative, ulmusakidian (1).
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Ginkgonitroside, a new nitrophenyl glycoside and bioactive compounds from Ginkgo biloba leaves controlling adipocyte and osteoblast differentiation.
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TL;DR: In this article, the authors reported the presence of nitrophenyl glycosides, which are relatively unique phytochemicals in natural products, in G. biloba, and examined their effects on the regulation of mesenchymal stem cell differentiation.
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Identification of bioactive compounds from mulberry enhancing glucose-stimulated insulin secretion.
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Molecular docking of phytochemicals against breast cancer: a review
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Phytochemical Investigation of Bioactive Compounds from White Kidney Beans (Fruits of Phaseolus multiflorus var. Albus): Identification of Denatonium with Osteogenesis-Inducing Effect
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TL;DR: In this article, a phytochemical investigation of the extract of P. multiflorus var. albus (Leguminosae), commonly known as “white kidney bean”, resulted in the isolation of three phenolic compounds (1, 3) and one dipeptide (4).
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