Journal ArticleDOI
Eukaryotic Ribosome Assembly
Jochen Baßler,Ed Hurt +1 more
Reads0
Chats0
TLDR
Light is shed on how nascent ribosomes progress stepwise along a dynamic biogenesis pathway and this information will lead to a better understanding of how ribosome synthesis is linked to other cellular pathways in humans and how it can cause diseases, including cancer, if disturbed.Abstract:
Ribosomes, which synthesize the proteins of a cell, comprise ribosomal RNA and ribosomal proteins, which coassemble hierarchically during a process termed ribosome biogenesis. Historically, biochem...read more
Citations
More filters
Journal ArticleDOI
The human 18S rRNA m6A methyltransferase METTL5 is stabilized by TRMT112.
Nhan van Tran,Felix G.M. Ernst,Ben R Hawley,Christiane Zorbas,Nathalie Ulryck,Philipp Hackert,Katherine E. Bohnsack,Markus T. Bohnsack,Samie R. Jaffrey,Marc Graille,Denis L. J. Lafontaine +10 more
TL;DR: It is proposed that METTL5–TRMT112 acts by extruding the adenosine to be modified from a double-stranded nucleic acid, supporting that its RNA-binding mode differs distinctly from that of other m6A RNA methyltransferases.
Journal ArticleDOI
RNA promotes the formation of spatial compartments in the nucleus
Sofia A. Quinodoz,Joanna W. Jachowicz,Prashant Bhat,Noah Ollikainen,Abhik Banerjee,Isabel N. Goronzy,Isabel N. Goronzy,Mario Blanco,Peter Chovanec,Amy Y. M. Chow,Yolanda Markaki,Jasmine Thai,Kathrin Plath,Mitchell Guttman +13 more
TL;DR: In this paper, the spatial organization of RNA and DNA in the nucleus has been comprehensively mapped to reveal higher-order RNA-chromatin structures associated with three major classes of nuclear function: RNA processing, heterochromatin assembly, and gene regulation.
Posted ContentDOI
RNA promotes the formation of spatial compartments in the nucleus
Sofia A. Quinodoz,Prashant Bhat,Prashant Bhat,Noah Ollikainen,Joanna W. Jachowicz,Abhik Banerjee,Abhik Banerjee,Peter Chovanec,Mario Blanco,Amy Y. M. Chow,Yolanda Markaki,Kathrin Plath,Mitchell Guttman +12 more
TL;DR: This work developed RNA & DNA SPRITE (RD-SPRITE) to comprehensively map the location of all RNAs relative to DNA and other RNAs and demonstrates a unique mechanism by which RNA acts to shape nuclear structure by forming high concentration territories immediately upon transcription, binding to diffusible regulators, and guiding them into spatial compartments to regulate a wide range of essential nuclear functions.
Journal ArticleDOI
Root of the Tree: The Significance, Evolution, and Origins of the Ribosome.
TL;DR: The ribosome shows that protein folding initiated with intrinsic disorder, supported through a short, primitive exit tunnel, and was enabled by a long, mature exit tunnel that partially offset the general thermodynamic tendency of all polypeptides to form β-sheets.
Journal ArticleDOI
Ribosome Biogenesis in Plants: From Functional 45S Ribosomal DNA Organization to Ribosome Assembly Factors
TL;DR: The functional organization of ribosomal DNA and ribosome assembly in plants is described, along with recent findings concerning a plant-specific mechanism involved in ribosomes stress responses.