European Position Paper on Rhinosinusitis and Nasal Polyps 2020
Wytske Fokkens,Valerie J. Lund,Joachim Mullol,Claus Bachert,Isam Alobid,Fuad M. Baroody,Noam A. Cohen,Anders Cervin,Richard Douglas,Philippe Gevaert,Christos Georgalas,Herman Goossens,Richard J. Harvey,Peter Hellings,Claire Hopkins,Nick Jones,Guy Joos,Livije Kalogjera,Bob Kern,Marek L. Kowalski,David Price,Herbert Riechelmann,Rodney J. Schlosser,Brent A. Senior,Mike Thomas,Elina Toskala,Richard Louis Voegels,De Yun Wang,Peter-John Wormald +28 more
TLDR
The European Position Paper on Rhinosinusitis and Nasal Polyps 2020 is the update of similar evidence based position papers published in 2005 and 2007 and 2012 and addresses areas not extensively covered in EPOS2012 such as paediatric CRS and sinus surgery.Abstract:
The European Position Paper on Rhinosinusitis and Nasal Polyps 2020 is the update of similar evidence based position papers published in 2005 and 2007 and 2012. The core objective of the EPOS2020 guideline is to provide revised, up-to-date and clear evidence-based recommendations and integrated care pathways in ARS and CRS. EPOS2020 provides an update on the literature published and studies undertaken in the eight years since the EPOS2012 position paper was published and addresses areas not extensively covered in EPOS2012 such as paediatric CRS and sinus surgery. EPOS2020 also involves new stakeholders, including pharmacists and patients, and addresses new target users who have become more involved in the management and treatment of rhinosinusitis since the publication of the last EPOS document, including pharmacists, nurses, specialised care givers and indeed patients themselves, who employ increasing self-management of their condition using over the counter treatments. The document provides suggestions for future research in this area and offers updated guidance for definitions and outcome measurements in research in different settings. EPOS2020 contains chapters on definitions and classification where we have defined a large number of terms and indicated preferred terms. A new classification of CRS into primary and secondary CRS and further division into localized and diffuse disease, based on anatomic distribution is proposed. There are extensive chapters on epidemiology and predisposing factors, inflammatory mechanisms, (differential) diagnosis of facial pain, allergic rhinitis, genetics, cystic fibrosis, aspirin exacerbated respiratory disease, immunodeficiencies, allergic fungal rhinosinusitis and the relationship between upper and lower airways. The chapters on paediatric acute and chronic rhinosinusitis are totally rewritten. All available evidence for the management of acute rhinosinusitis and chronic rhinosinusitis with or without nasal polyps in adults and children is systematically reviewed and integrated care pathways based on the evidence are proposed. Despite considerable increases in the amount of quality publications in recent years, a large number of practical clinical questions remain. It was agreed that the best way to address these was to conduct a Delphi exercise . The results have been integrated into the respective sections. Last but not least, advice for patients and pharmacists and a new list of research needs are included. The full document can be downloaded for free on the website of this journal: http://www.rhinologyjournal.com.read more
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Journal ArticleDOI
EPOS 2012: European position paper on rhinosinusitis and nasal polyps 2012. A summary for otorhinolaryngologists
Wytske Fokkens,Valerie J. Lund,Joachim Mullol,Claus Bachert,Isam Alobid,Fuad M. Baroody,Noam A. Cohen,Anders Cervin,Richard G. Douglas,Philippe Gevaert,Christos Georgalas,Herman Goossens,Richard J. Harvey,Peter Hellings,Claire Hopkins,Nick Jones,Guy Joos,Livije Kalogjera,Bob Kern,Marek L. Kowalski,David Price,Herbert Riechelmann,Rodney J. Schlosser,Brent A. Senior,Mike Thomas,Elina Toskala,Richard Louis Voegels,De Yun Wang,Peter-John Wormald,Peter-John Wormald +29 more
TL;DR: The European Position Paper on Rhinosinusitis and Nasal Polyps 2012 as discussed by the authors is the update of similar evidence-based position papers published in 2005 and 2007, it contains chapters on definitions and classification, we now also proposed definitions for difficult to treat rhinositis, control of disease, and better definitions for rhinosinitis in children.
Journal ArticleDOI
Chronic rhinosinusitis in Europe : an underestimated disease. A GA²LEN study
Deniz Hastan,W. J. Fokkens,Claus Bachert,Roger Newson,J Bislimovska,Angelina Bockelbrink,Philippe-Jean Bousquet,Grzegorz Brożek,Andreina Bruno,SE Dahlen,Bertil Forsberg,Maria Gunnbjörnsdottir,Lukasz Kasper,Ursula Krämer,Marek L. Kowalski,B Lange,Bo Lundbäck,E Salagean,Ana Todo-Bom,Peter Tomassen,Elina Toskala,C. M. van Drunen,Jean Bousquet,T. Zuberbier,Deborah Jarvis,Peter Burney +25 more
TL;DR: This data indicates that rhinosinusitis in Europe is an underestimated disease, and the number of patients diagnosed with the disease and the severity of the disease should be increased.
Journal ArticleDOI
Clinical Practice Guideline (Update) Adult Sinusitis
Richard M. Rosenfeld,Jay F. Piccirillo,Sujana S. Chandrasekhar,Itzhak Brook,Kaparaboyna Ashok Kumar,Maggie A. Kramper,Richard R. Orlandi,James N. Palmer,Zara M. Patel,Anju T. Peters,Sandra A. Walsh,Maureen D. Corrigan +11 more
TL;DR: This update of a 2007 guideline from the American Academy of Otolaryngology—Head and Neck Surgery Foundation provides evidence-based recommendations to manage adult rhinosinusitis, defined as symptomatic inflammation of the paranasal sinuses and nasal cavity.
Journal ArticleDOI
Inflammatory endotypes of chronic rhinosinusitis based on cluster analysis of biomarkers.
Peter Tomassen,Griet Vandeplas,Thibaut Van Zele,Lars-Olaf Cardell,Julia Arebro,Heidi Olze,U Förster-Ruhrmann,Marek L. Kowalski,Agnieszka Olszewska-Ziąber,Gabriele Holtappels,Natalie De Ruyck,Xiangdong Wang,Cornelis M. van Drunen,Joaquim Mullol,Peter Hellings,Valérie Hox,Elina Toskala,Glenis Scadding,Valerie J. Lund,Luo Zhang,Wytske Fokkens,Claus Bachert,Claus Bachert +22 more
TL;DR: Distinct CRS clusters with diverse inflammatory mechanisms largely correlated with phenotypes and further differentiated them and provided a more accurate description of the inflammatory mechanisms involved than phenotype information only.
Journal ArticleDOI
Adaptation of Pseudomonas aeruginosa to the cystic fibrosis airway: an evolutionary perspective
Anders Folkesson,Lars Jelsbak,Lei Yang,Lei Yang,Helle Krogh Johansen,Oana Ciofu,Niels Høiby,Niels Høiby,Søren Molin +8 more
TL;DR: This work discusses how P. aeruginosa evolves from a state of early, recurrent intermittent colonization of the airways of patients with CF to a chronic infection state, and how this process offers opportunities to study bacterial evolution in natural environments.
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