Journal ArticleDOI
Evaluation of the pharmacodynamics and pharmacokinetics of brucine following transdermal administration
Jun Chen,Wei Hu,Ye-qing Qu,Jie Dong,Wei Gu,Ying Gao,Yun Fang,Fang Fang,Zhipeng Chen,Baochang Cai +9 more
TLDR
The results of this study indicated that transdermal administration might be beneficial for the sustained efficacy and reduced toxicity of brucine.About:
This article is published in Fitoterapia.The article was published on 2013-04-01. It has received 16 citations till now. The article focuses on the topics: Brucine & Transdermal.read more
Citations
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Journal ArticleDOI
Evaluation of skin absorption of drugs from topical and transdermal formulations
André Luís Morais Ruela,Aline Gravinez Perissinato,Mônica Esselin de Sousa Lino,Paula Silva Mudrik,Gislaine Ribeiro Pereira +4 more
TL;DR: This review covers the most well-known methods for assessing the cutaneous absorption of drugs as an auxiliary tool for pharmaceutical formulation scientists in the design of drug delivery systems.
Journal ArticleDOI
Hierarchical targeted hepatocyte mitochondrial multifunctional chitosan nanoparticles for anticancer drug delivery.
Zhipeng Chen,Zhipeng Chen,Liu-Jie Zhang,Yang Song,Jiayu He,Wu Li,Can Zhao,Yanyu Xiao,Wei Li,Baochang Cai,Haibo Cheng,Weidong Li +11 more
TL;DR: A novel mitochondrial-targeted multifunctional nanoparticles based on chitosan derivatives provides a safe and efficient nanocarrier platform for mitochondria targeting anticancer drug delivery and realizes the efficient intracellular delivery and mitochondrial localization.
Journal ArticleDOI
Brucine: A Review of Phytochemistry, Pharmacology, and Toxicology.
TL;DR: The physicochemical properties, pharmacological activities, and toxicity of brucine were reviewed, and the novel strategies to address the toxicity issues were discussed, aiming to bring new insights into further research and application of this active component.
Journal ArticleDOI
Repurposing of plant alkaloids for cancer therapy: Pharmacology and toxicology.
Thomas Efferth,Franz Oesch +1 more
TL;DR: The present survey of the published literature clearly demonstrates that plant alkaloids have the potential for repositioning in cancer therapy.
Journal ArticleDOI
Nasal delivery of analgesic ketorolac tromethamine thermo- and ion-sensitive in situ hydrogels.
TL;DR: The thermo- and ion-sensitive KT ISG had appropriate gelation temperature, sustained drug release, improved intranasal absorption, obvious pharmacodynamic effect, and negligible nasal ciliotoxicity.
References
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Journal ArticleDOI
Ethosomes for skin delivery of ammonium glycyrrhizinate: in vitro percutaneous permeation through human skin and in vivo anti-inflammatory activity on human volunteers.
TL;DR: Ethosomes were able to significantly enhance the anti-inflammatory activity of ammonium glycyrrhizinate compared to the ethanolic or aqueous solutions of this drug.
Journal ArticleDOI
Analgesic and anti-inflammatory properties of brucine and brucine N-oxide extracted from seeds of Strychnos nux-vomica.
TL;DR: The results suggest that central and peripheral mechanism are involved in the pain modulation and anti-inflammation effects of brucine and Brucine N-oxide, biochemical mechanisms of bru cine and brucines N -oxide are different even though they are similar in chemical structure.
Journal ArticleDOI
The anti-tumor effects of alkaloids from the seeds of Strychnos nux-vomica on HepG2 cells and its possible mechanism
Xu-Kun Deng,Wu Yin,Weidong Li,Fangzhou Yin,Xiaoyu Lu,Xiao-Chun Zhang,Zi-Chun Hua,Baochang Cai +7 more
TL;DR: It is indicated that the major alkaloids present in the seed of Strychnos nux-vomica are effective against HepG2 cells proliferation, among which brucine proceed HepG 2 cells death via apoptosis, probably through the participation of caspase-3 and cyclooxygenase-2.
Journal ArticleDOI
The apoptotic effect of brucine from the seed of Strychnos nux-vomica on human hepatoma cells is mediated via Bcl-2 and Ca2+ involved mitochondrial pathway.
TL;DR: Ca2+ and Bcl-2 mediated mitochondrial pathway were found to be involved in brucine-induced HepG2 cell apoptosis, and suggested a pivotal role of mitochondrial membrane depolarization in HepG1 cell apoptotic programmed cell death elicited by Brucine.
Journal ArticleDOI
Analgesic and anti-inflammatory activity and pharmacokinetics of alkaloids from seeds of Strychnos nux-vomica after transdermal administration: Effect of changes in alkaloid composition
Jun Chen,Xuan Wang,Xuan Wang,Yan-ge Qu,Yan-ge Qu,Zhi-peng Chen,Zhi-peng Chen,Hao Cai,Hao Cai,Xiao Liu,Xiao Liu,Fei Xu,Tu-lin Lu,Tu-lin Lu,Cai Baochang,Cai Baochang +15 more
TL;DR: The results from the present study appeared to support the viewpoint that most strychnine should be removed from TAF to improve analgesic and anti-inflammatory activity.