Journal ArticleDOI
Evaluation of trivalent, live, cold-adapted (CAIV-T) and inactivated (TIV) influenza vaccines in prevention of virus infection and illness following challenge of adults with wild-type influenza A (H1N1), A (H3N2), and B viruses.
John J. Treanor,Karen L. Kotloff,Robert F. Betts,Robert B. Belshe,Fran Newman,Dominick Iacuzio,Janet Wittes,Martin Bryant +7 more
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TLDR
Results are consistent with those of previous studies using monovalent preparations of cold-adapted influenza vaccine in this model, and indicate that CAIV-T will be an effective means to prevent influenza illness in adults.About:
This article is published in Vaccine.The article was published on 1999-12-10. It has received 246 citations till now. The article focuses on the topics: Influenza vaccine & Influenza A virus.read more
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Prevention and control of influenza : recommendations of the Advisory Committee on Immunization Practices (ACIP)
TL;DR: This report updates the 2000 recommendations by the Advisory Committee on Immunization Practices on the use of influenza vaccine and antiviral agents with new or updated information regarding the cost-effectiveness of influenza vaccination and the 2001-2002 trivalent vaccine virus strains.
Journal Article
Prevention and control of seasonal influenza with vaccines: recommendations of the Advisory Committee on Immunization Practices (ACIP), 2009.
Anthony E. Fiore,Timothy M. Uyeki,Karen R. Broder,Lyn Finelli,Gary L. Euler,James A. Singleton,John K. Iskander,Pascale M. Wortley,David K. Shay,Joseph S. Bresee,Nancy J. Cox +10 more
TL;DR: This report updates the 2008 recommendations by CDC's Advisory Committee on Immunization Practices regarding the use of influenza vaccine for the prevention and control of seasonal influenza and includes a summary of safety data for U.S. licensed influenza vaccines.
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Prevention and Control of Seasonal Influenza with Vaccines: Recommendations of the Advisory Committee on Immunization Practices - United States, 2020-21 Influenza Season.
Lisa A. Grohskopf,Leslie Z. Sokolow,Leslie Z. Sokolow,Sonja J. Olsen,Joseph S. Bresee,Karen R. Broder,Ruth A. Karron +6 more
TL;DR: This report updates the 2017–18 recommendations of the Advisory Committee on Immunization Practices regarding the use of seasonal influenza vaccines in the United States and focuses on the recommendations for use of vaccines for the prevention and control of influenza during the 2018–19 season.
Journal ArticleDOI
Time Lines of Infection and Disease in Human Influenza: A Review of Volunteer Challenge Studies
Fabrice Carrat,Fabrice Carrat,Elisabeta Vergu,Elisabeta Vergu,Elisabeta Vergu,Neil M. Ferguson,Magali Lemaitre,Magali Lemaitre,Simon Cauchemez,Steve Leach,Alain-Jacques Valleron,Alain-Jacques Valleron +11 more
TL;DR: Prior expert opinion on the duration of viral shedding or the frequency of asymptomatic influenza infection is confirmed, prior knowledge on the dynamics of viral shed and symptoms is extended, and original results on the frequencyof respiratory symptoms or fever are provided.
Journal ArticleDOI
Influenza Virus: Immunity and Vaccination Strategies. Comparison of the Immune Response to Inactivated and Live, Attenuated Influenza Vaccines
TL;DR: An update of the current status on influenza vaccination is provided and concentrates on the two main types of influenza vaccines currently in use, namely the cold‐adapted vaccine (CAV) given intranasally/orally, and the inactivated vaccine (IV) delivered subcutanously or intramuscularly.
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Journal ArticleDOI
The Efficacy of Live Attenuated, Cold-Adapted, Trivalent, Intranasal Influenzavirus Vaccine in Children
Robert B. Belshe,Paul M. Mendelman,John J. Treanor,James C. King,William C. Gruber,Pedro A. Piedra,David I. Bernstein,Frederick G. Hayden,Karen L. Kotloff,Kenneth M. Zangwill,Dominick Iacuzio,Mark Wolff +11 more
TL;DR: A live attenuated, cold-adapted, trivalent influenzavirus vaccine was safe, immunogenic, and effective against influenza A(H3N2) and B in healthy children.
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A Randomized Controlled Trial of Cold-Adapted and Inactivated Vaccines for the Prevention of Influenza A Disease
Kathryn M. Edwards,William D. Dupont,Mary K. Westrich,Walton D. Plummer,Pamela Palmer,Peter F. Wright +5 more
TL;DR: Cold-adapted and inactivated influenza vaccines are safe and effective for preventing influenza A disease and significantly increased hemagglutination inhibition antibody titers.
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Safety and Efficacy of the Neuraminidase Inhibitor GG167 in Experimental Human Influenza
Frederick G. Hayden,John J. Treanor,Robert F. Betts,Monica C. Lobo,James D. Esinhart,Elizabeth K. Hussey +5 more
TL;DR: Direct respiratory administration of the selective neuraminidase inhibitor GG167 appears safe and effective for both prevention and early treatment of experimental influenza.
Journal ArticleDOI
Development and characterization of cold-adapted viruses for use as live virus vaccines
Hunein F. Maassab,Dan C. DeBorde +1 more
TL;DR: Overall, the best method of cold adaptation to develop a live virus vaccine line appeared to be a stepwise lowering of the growth temperature allowing time for multiple lesions to occur and/or be selected.
Journal ArticleDOI
Temperature-Sensitive Mutants of Influenza Virus. III. Further Characterization of the ts-1[E] Influenza A Recombinant (H3N2) Virus in Man
TL;DR: Overall the pattern of infection produced by the ts-l[E] recombinant virus was comparable to that seen with wild-type virus but was of shorter duration and lesser magnitude, which makes it suitable for use as a live influenza A vaccine in man.