Evolution of H9N2 influenza viruses from domestic poultry in Mainland China
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TLDR
The findings suggest that urgent attention should be paid to the control of H9N2 influenza viruses in animals and to the human's influenza pandemic preparedness.About:
This article is published in Virology.The article was published on 2005-09-15 and is currently open access. It has received 300 citations till now. The article focuses on the topics: Influenza A virus & H5N1 genetic structure.read more
Citations
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Journal ArticleDOI
The Evolutionary Genetics and Emergence of Avian Influenza Viruses in Wild Birds
Vivien G. Dugan,Rubing Chen,David J. Spiro,Naomi Sengamalay,Jennifer Zaborsky,Elodie Ghedin,Jacqueline M. Nolting,David E. Swayne,Jonathan A. Runstadler,George M. Happ,Dennis A. Senne,Ruixue Wang,Richard D. Slemons,Edward C. Holmes,Jeffery K. Taubenberger +14 more
TL;DR: It is proposed that AIV in wild birds forms transient “genome constellations,” continually reshuffled by reassortment, in contrast to the spread of a limited number of stable genome constellation that characterizes the evolution of mammalian-adapted influenza A viruses.
Journal ArticleDOI
The NS1 Gene Contributes to the Virulence of H5N1 Avian Influenza Viruses
Zejun Li,Yongping Jiang,Peirong Jiao,Aiqin Wang,Fengju Zhao,Guobin Tian,Xijun Wang,Kangzhen Yu,Zhigao Bu,Hualan Chen +9 more
TL;DR: The results indicate that the NS1 gene is critical for the pathogenicity of avian influenza virus in chickens and that the amino acid residue Ala149 correlates with the ability of these viruses to antagonize interferon induction in CEFs.
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Replication and Transmission of H9N2 Influenza Viruses in Ferrets: Evaluation of Pandemic Potential
Hongquan Wan,Erin M. Sorrell,Haichen Song,Jaber Hossain,Gloria Ramirez-Nieto,Isabella Monne,James Stevens,Giovanni Cattoli,Ilaria Capua,Li-Mei Chen,Ruben O. Donis,Julia Busch,James C. Paulson,Christy Brockwell,Richard J. Webby,Jorge Blanco,Mohammad Q. Al-Natour,Daniel R. Perez +17 more
TL;DR: The results suggest that the establishment and prevalence of H9N2 viruses in poultry pose a significant threat for humans.
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Amino Acid 226 in the Hemagglutinin of H9N2 Influenza Viruses Determines Cell Tropism and Replication in Human Airway Epithelial Cells
Hongquan Wan,Daniel R. Perez +1 more
TL;DR: The results suggest that the variation in residue 226 in the HA affects both cell tropism and replication of H9N2 viruses in HAE cells and may have implications for the abilities of these viruses to infect humans.
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Evolution of the H9N2 influenza genotype that facilitated the genesis of the novel H7N9 virus
Juan Pu,Shuoguo Wang,Yanbo Yin,Guozhong Zhang,Robert A. Carter,Jinliang Wang,Guanlong Xu,Honglei Sun,Min Wang,Chu Wen,Wei Yandi,Dongdong Wang,Baoli Zhu,Gordon Lemmon,Yuannian Jiao,Susu Duan,Qian Wang,Qian Du,Meng Sun,Jinnan Bao,Yipeng Sun,Jixun Zhao,Hui Zhang,Gang Wu,Jinhua Liu,Robert G. Webster +25 more
TL;DR: Over more than 10 y of cocirculation of multiple H9N2 genotypes, a “fittest” genotype emerged with changed antigenicity and improved adaptability in chickens that became predominant in vaccinated farm chickens in China and caused widespread outbreaks before the H7N9 virus emergence.
References
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Journal ArticleDOI
Evolution and ecology of influenza A viruses.
TL;DR: Wild aquatic bird populations have long been considered the natural reservoir for influenza A viruses with virus transmission from these birds seeding other avian and mammalian hosts, but recent studies in bats have suggested other reservoir species may also exist.
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Characterization of a Novel Influenza A Virus Hemagglutinin Subtype (H16) Obtained from Black-Headed Gulls
Ron A. M. Fouchier,Vincent J. Munster,Anders Wallensten,Theo M. Bestebroer,Sander Herfst,Derek J. Smith,Derek J. Smith,Gus F. Rimmelzwaan,Bjorn R. Olsen,Albert D. M. E. Osterhaus +9 more
TL;DR: A previously unidentified antigenic subtype of HA (H16), detected in viruses circulating in black-headed gulls in Sweden, is described and proposed that sequence analyses of HA and NA genes of influenza A viruses be used for the rapid identification of existing and novel HA andNA subtypes.
Journal ArticleDOI
A review of avian influenza in different bird species
TL;DR: Only type A influenza viruses are known to cause natural infections in birds, but viruses of all 15 haemagglutinin and all nine neuraminidase influenza A subtypes in the majority of possible combinations have been isolated from avian species.
Journal ArticleDOI
Human infection with influenza H9N2
Malik Peiris,Kwok-Yung Yuen,C. W. Leung,Kwok-Hung Chan,P. L. S. Ip,Raymond Lai,W. K. Orr,Kennedy F. Shortridge +7 more
TL;DR: It is shown that serum samples from blood donors in Hong Kong had neutralising antibody suggestive of prior infection with influenza H9N2.
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A single amino acid in the PB2 gene of influenza A virus is a determinant of host range.
TL;DR: The nucleotide sequences of thePB2 gene of each of the four hr mutants revealed that a single amino acid substitution at position 627 (Glu-->Lys) was responsible for the restoration of the ability of the PB2 single gene reassortant to replicate in Madin-Darby canine kidney cells.