Expression cloning of 2-5A-dependent RNAase: A uniquely regulated mediator of interferon action
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TLDR
Analysis of aligned murine and human 2-5A-dependent RNAse sequences revealed several intriguing features, including similarity to RNAase E, which is implicated in the control of mRNA stability in E. coli.About:
This article is published in Cell.The article was published on 1993-03-12 and is currently open access. It has received 526 citations till now. The article focuses on the topics: RNase P & Expression cloning.read more
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How cells respond to interferons
TL;DR: The Janus kinases and signal transducers and activators of transcription, and many of the interferon-induced proteins, play important alternative roles in cells, raising interesting questions as to how the responses to the interFERons intersect with more general aspects of cellular physiology and how the specificity of cytokine responses is maintained.
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Antiviral Actions of Interferons
TL;DR: Tremendous progress has been made in understanding the molecular basis of the antiviral actions of interferons (IFNs), as well as strategies evolved by viruses to antagonize the actions of IFNs.
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Viruses and interferon: a fight for supremacy
TL;DR: The interplay between the IFN system and four medically important and challenging viruses — influenza, hepatitis C, herpes simplex and vaccinia — is discussed to highlight the diversity of viral strategies.
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Targeted mRNA degradation by double-stranded RNA in vitro
TL;DR: The development of a cell-free system from syncytial blastoderm Drosophila embryos that recapitulates many of the features of RNAi is reported, demonstrating that RNAi can be mediated by sequence-specific processes in soluble reactions.
Patent
Rna interference mediating small rna molecules
TL;DR: In this article, the authors demonstrate that 19-23 nt short RNA fragments are the sequence-specific mediators of RNA interference in a Drosophila in vitro system, and provide evidence that the direction of dsRNA processing determines whether sense or antisense target RNA can be cleaved by the produced siRNA complex.
References
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