Journal ArticleDOI
Factors Promoting Tamoxifen Resistance in Breast Cancer via Stimulating Breast Cancer Stem Cell Expansion.
Diane Ojo,Fengxiang Wei,Yun Liu,Enli Wang,Hongde Zhang,Xiaozeng Lin,Nicholas C. Wong,Anita Bane,Damu Tang +8 more
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TLDR
Recent developments of BCSC-mediated resistance to tamoxifen and the contributions of those demonstrated molecular factors/pathways to BCSC expansion during the emergency of tamoxIFen resistance are discussed.Abstract:
Estrogen receptor-alpha positive (ER + ) breast cancer constitutes 70-75% of the disease incidence Tamoxifen
has been the basis of endocrine therapy for patients with ER + breast cancer for more than three decades The treatment reduces
the annual mortality rate of breast cancer by 31%, and remains the most effective targeted cancer therapy However,
approximately one-third of patients treated with adjuvant tamoxifen suffer from aggressive recurrent disease Resistance
to tamoxifen, thus, remains a major challenge in providing effective treatments for these patients In an effort to overcome
the resistance, intensive research has been conducted to understand the underlying mechanisms; this has resulted in the
identification of complex factors/pathways contributing to tamoxifen resistance, including modulations of the ERsignaling,
upregulation of a set of growth factor receptor networks (HER2, EGFR, FGFR, and IGF1R), alterations of the
PI3K-PTEN/AKT/mTOR pathway, and an elevation of the NF-κB signaling Despite these advances, our understanding
of the acquired resistance remains fragmented and there is a lack of a platform to integrate these diversified molecular factors/
pathways into a cohesive mechanistic model Nonetheless, at the cellular level, it is becoming increasingly recongnized
that cancer stem cells (CSCs) are key in driving cancer metastasis and therapy resistance Likewise, evidence is
emerging for the critical contributions of breast cancer stem cells (BCSCs) to tamoxifen resistance In this review, we will
discuss these recent developments of BCSC-mediated resistance to tamoxifen and the contributions of those demonstrated
molecular factors/pathways to BCSC expansion during the emergency of tamoxifen resistanceread more
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Journal ArticleDOI
Endocrine resistance in breast cancer--An overview and update.
TL;DR: This review explores the basic mechanisms of resistance to endocrine therapies, concluding with some new insights from systems biology approaches further implicating autophagy and the UPR in detail, and a brief discussion of exciting new avenues and future prospects.
Journal ArticleDOI
circRNA_0025202 Regulates Tamoxifen Sensitivity and Tumor Progression via Regulating the miR-182-5p/FOXO3a Axis in Breast Cancer
Yuting Sang,Bing Chen,Xiaojin Song,Yaming Li,Yiran Liang,Dianwen Han,Ning Zhang,Hanwen Zhang,Ying Liu,Tong Chen,Chen Li,Lijuan Wang,Wenjing Zhao,Qifeng Yang +13 more
TL;DR: Hsa_circ_0025202 served an anti-oncogenic role in HR-positive breast cancer, and it could be exploited as a novel marker for tamoxifen-resistant breast cancer.
Journal ArticleDOI
Fibroblast Subtypes Regulate Responsiveness of Luminal Breast Cancer to Estrogen.
Heather M. Brechbuhl,Jessica Finlay-Schultz,Tomomi M. Yamamoto,Austin E. Gillen,Diana M. Cittelly,Aik Choon Tan,Sharon Sams,Manoj M. Pillai,Anthony D. Elias,William A. Robinson,Carol A. Sartorius,Peter Kabos +11 more
TL;DR: It is demonstrated that ER+ breast cancers contain two CAF subtypes defined by CD146 expression, which suggest that CAF composition contributes to treatment response and patient outcomes in ER+, and should be considered a target for drug development.
Journal ArticleDOI
LncRNA UCA1 in anti-cancer drug resistance.
TL;DR: The potential of lncRNA UCA1 as a diagnostic and prognostic biomarker, and a therapeutic target in malignant tumors, is highlighted and its potential in future clinical applications is discussed.
Journal ArticleDOI
Knockdown of Long Non-Coding RNA UCA1 Increases the Tamoxifen Sensitivity of Breast Cancer Cells through Inhibition of Wnt/β-Catenin Pathway.
TL;DR: The expression of UCA1 positively correlated with the pathological grade and mortality of breast cancer patients, moreover, expressions of U CA1 was increased significantly in the tamoxifen-resistant cell lines compared with the wild type parental cells, which highlights the pivotal role of Uca1-Wnt/β-catenin signaling pathway in theTamoxIFen resistance in breast cancer.
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