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Faculty of 1000 evaluation for A transfer-RNA-derived small RNA regulates ribosome biogenesis.
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The article was published on 2018-02-07. It has received 42 citations till now. The article focuses on the topics: Small RNA & Ribosome biogenesis.read more
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Small RNA Sequencing Reveals Transfer RNA-derived Small RNA Expression Profiles in Retinal Neovascularization
Yingqian Peng,Jingling Zou,Jiang-Hui Wang,Huilan Zeng,Wei Tan,Shigeo Yoshida,Liwei Zhang,Yun Li,Yedi Zhou +8 more
TL;DR: This study suggests tsRNAs play key roles in the pathogenesis of RNV, indicating their therapeutic potential to treat patients with RNV and small RNA sequencing is a useful tool to identify changes in tsRNA expression, an important indicator of the progress of retinal diseases.
Posted ContentDOI
Control of noncoding RNA production and histone levels by a 5′ tRNA fragment
TL;DR: Together, the data reveal a conserved mechanism for 5’ tRNA fragment control of noncoding RNA biogenesis and, consequently, in global chromatin organization.
Journal ArticleDOI
Deletion of Endonuclease V suppresses chemically induced hepatocellular carcinoma
Xiang Yi Kong,Erik Sebastian Vik,Meh Sameen Nawaz,Natalia Berges,Tuva B. Dahl,Cathrine Broberg Vågbø,Rajikala Suganthan,Filip M. Segers,Sverre Holm,Ana Quiles-Jiménez,Ana Quiles-Jiménez,Ida Gregersen,Cathrine Fladeby,Pål Aukrust,Pål Aukrust,Magnar Bjørås,Magnar Bjørås,Arne Klungland,Arne Klungland,Bente Halvorsen,Bente Halvorsen,Ingrun Alseth +21 more
TL;DR: It is speculated that the inosine-ribonuclease activity of EndoV is disabled in vivo, but RNA binding allowed to promote stabilization of transcripts or recruitment of proteins to fine-tune gene expression, which calls for related studies in human HCC.
Journal ArticleDOI
tRNA-derived small RNAs: Mechanisms and potential roles in cancers
TL;DR: In this article , the classification, biogenesis, and mechanism of action of transfer RNAs in cancer were reviewed and new opportunities for diagnostic biomarkers and treatment targets of several types of cancers including gastric cancer, colorectal cancer, hepatocellular carcinomas, pancreatic cancer, breast cancer, ovarian cancer, renal cell carcinoma, lung cancer, bladder cancer, thyroid cancer, oral cancer, and leukemia.
Journal ArticleDOI
A Standardized Ontology for Naming tRNA-derived RNAs Based on Molecular Origin
Andrew D. Holmes,Patricia P. Chan,Pavel Ivanov,Laurence Drouard,Norbert Polacek,Mark A. Kay,Todd M. Lowe +6 more
TL;DR: An improved nomenclature for tRNA-derived small RNAs is proposed, facilitated by the tDRnamer system, to promote inter-study comparisons leveraging a biologically-rooted nomenClature for this emerging class of intriguing regulators.
References
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tRNA-Derived Small RNA: A Novel Regulatory Small Non-Coding RNA
TL;DR: The biogeneses of various tsRNAs are summarized, the emerging concepts regarding functions and mechanisms of action are presented, the potential application of ts RNAs in human diseases is highlighted, and the current problems and future research directions are put forward.
Journal ArticleDOI
miRNA-based biomarkers, therapies, and resistance in Cancer.
Boxue He,Zhenyu Zhao,Qidong Cai,Yuqian Zhang,Pengfei Zhang,Shuai Shi,Hui Xie,Xiong Peng,Wei Yin,Yongguang Tao,Xiang Wang +10 more
TL;DR: It is demonstrated that many miRNAs are engaged in the resistance of cancer therapies with their complex underlying regulatory mechanisms, whose comprehensive cognition can help clinicians and improve patient prognosis.
Journal ArticleDOI
Plant RNases T2, but not Dicer-like proteins, are major players of tRNA-derived fragments biogenesis.
Cyrille Megel,Guillaume Hummel,Stéphanie Lalande,Elodie Ubrig,Valérie Cognat,Geoffrey Morelle,Thalia Salinas-Giegé,Anne-Marie Duchêne,Laurence Maréchal-Drouard +8 more
TL;DR: It is demonstrated that the Arabidopsis RNases T2, called RNS, are key players of both long and short tRFs biogenesis, and an evolutionary conserved feature of these enzymes in eukaryotes is suggested.
Journal ArticleDOI
Development of miRNA-based therapeutic approaches for cancer patients.
TL;DR: Recent progress in the development of miRNA therapeutics for the treatment of cancer patients is summarized, and delivery systems for oligonucleotide therapeutics are described.
Journal ArticleDOI
Drosophila tsRNAs preferentially suppress general translation machinery via antisense pairing and participate in cellular starvation response.
TL;DR: The study suggests the tsRNA-mediated regulation might be crucial for the energy homeostasis and the metabolic adaptation in the cellular systems.