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Faculty of 1000 evaluation for A transfer-RNA-derived small RNA regulates ribosome biogenesis.
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The article was published on 2018-02-07. It has received 42 citations till now. The article focuses on the topics: Small RNA & Ribosome biogenesis.read more
Citations
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Journal ArticleDOI
tRNA-Derived Small RNA: A Novel Regulatory Small Non-Coding RNA
TL;DR: The biogeneses of various tsRNAs are summarized, the emerging concepts regarding functions and mechanisms of action are presented, the potential application of ts RNAs in human diseases is highlighted, and the current problems and future research directions are put forward.
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miRNA-based biomarkers, therapies, and resistance in Cancer.
Boxue He,Zhenyu Zhao,Qidong Cai,Yuqian Zhang,Pengfei Zhang,Shuai Shi,Hui Xie,Xiong Peng,Wei Yin,Yongguang Tao,Xiang Wang +10 more
TL;DR: It is demonstrated that many miRNAs are engaged in the resistance of cancer therapies with their complex underlying regulatory mechanisms, whose comprehensive cognition can help clinicians and improve patient prognosis.
Journal ArticleDOI
Plant RNases T2, but not Dicer-like proteins, are major players of tRNA-derived fragments biogenesis.
Cyrille Megel,Guillaume Hummel,Stéphanie Lalande,Elodie Ubrig,Valérie Cognat,Geoffrey Morelle,Thalia Salinas-Giegé,Anne-Marie Duchêne,Laurence Maréchal-Drouard +8 more
TL;DR: It is demonstrated that the Arabidopsis RNases T2, called RNS, are key players of both long and short tRFs biogenesis, and an evolutionary conserved feature of these enzymes in eukaryotes is suggested.
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Development of miRNA-based therapeutic approaches for cancer patients.
TL;DR: Recent progress in the development of miRNA therapeutics for the treatment of cancer patients is summarized, and delivery systems for oligonucleotide therapeutics are described.
Journal ArticleDOI
Drosophila tsRNAs preferentially suppress general translation machinery via antisense pairing and participate in cellular starvation response.
TL;DR: The study suggests the tsRNA-mediated regulation might be crucial for the energy homeostasis and the metabolic adaptation in the cellular systems.
References
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Journal ArticleDOI
tRNA-Derived Small RNAs and Their Potential Roles in Cardiac Hypertrophy
TL;DR: It is anticipated that this new class of small non-coding RNAs will offer new perspectives in understanding disease mechanisms and may provide new therapeutic targets to treat cardiovascular disease.
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Transfer RNA-Derived Small Non-Coding RNA: Dual Regulator of Protein Synthesis.
TL;DR: The detailed mechanism of tsRNA-mediated dual regulation in protein synthesis is highlighted and the necessity of novel sequencing technology to learn more about tsRNAs is discussed.
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Integrative analysis of transcriptomes highlights potential functions of transfer-RNA-derived small RNAs in experimental intracerebral hemorrhage.
Pengfei Li,Pengfei Li,Shi-Chao Guo,Tao Liu,Hanjin Cui,Dandan Feng,Ali Yang,Zhe Cheng,Jiekun Luo,Tao Tang,Yang Wang +10 more
TL;DR: This study systematically revealed the profiles of tsRNAs after an experimental intracerebral hemorrhage, and these results may provide novel therapeutic targets following a hemorrhagic stroke in the chronic phase.
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Differential Expression Profiles and Functional Prediction of tRNA-Derived Small RNAs in Rats After Traumatic Spinal Cord Injury.
Chuan Qin,Hao Feng,Chao Zhang,Xin Zhang,Liu Yi,Degang Yang,Liang-Jie Du,Ying-Chun Sun,Ying-Chun Sun,Mingliang Yang,Feng Gao,Jianjun Li +11 more
TL;DR: An altered tsRNA expression pattern is found and predicted tiRNA-Gly-GCC-001 might be involved in the MAPK and neurotrophin pathways by targeting the BDNF, thus regulating the post-SCI pathophysiologic processes.
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The role of Transfer RNA-Derived Small RNAs (tsRNAs) in Digestive System Tumors.
TL;DR: This review focused on the relationship of tRFs and tiRNAs with the biological behavior, clinicopathological characteristics, diagnosis, treatment and prognosis of digestive system tumors, and would provide novel insights for the early detection and treatment of digestiveSystem tumors.