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Faculty of 1000 evaluation for A transfer-RNA-derived small RNA regulates ribosome biogenesis.
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The article was published on 2018-02-07. It has received 42 citations till now. The article focuses on the topics: Small RNA & Ribosome biogenesis.read more
Citations
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Journal ArticleDOI
A novel tyrosine tRNA-derived fragment, tRFTyr, induces oncogenesis and lactate accumulation in LSCC by interacting with LDHA
Rui Zhao,Zhenming Yang,Bo Zhao,Wenjing Li,Yao-Bei Liu,Xiaoxue Chen,Jing Cao,Jiarui Zhang,Yan-Ling Guo,Licheng Xu,Jinpeng Wang,Yanan Sun,Ming Li,Linli Tian +13 more
TL;DR: In this article , the role of transfer (t)RNA-derived small RNA (tsRNA) in laryngeal squamous cell carcinoma (LSCC) remains unclear.
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A ligation-independent sequencing method reveals tRNA-derived RNAs with blocked 3’ termini
Alessandro Scacchetti,Emily J. Shields,Natalie A. Trigg,Jeremy E. Wilusz,Colin C. Conine,Roberto Bonasio +5 more
TL;DR: In this paper , a method to construct sequencing libraries from RNA molecules of any length and with any type of 3' terminal modification, allowing the sequencing and analysis of virtually all RNA species is presented.
References
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tRNA-Derived Small RNA: A Novel Regulatory Small Non-Coding RNA
TL;DR: The biogeneses of various tsRNAs are summarized, the emerging concepts regarding functions and mechanisms of action are presented, the potential application of ts RNAs in human diseases is highlighted, and the current problems and future research directions are put forward.
Journal ArticleDOI
miRNA-based biomarkers, therapies, and resistance in Cancer.
Boxue He,Zhenyu Zhao,Qidong Cai,Yuqian Zhang,Pengfei Zhang,Shuai Shi,Hui Xie,Xiong Peng,Wei Yin,Yongguang Tao,Xiang Wang +10 more
TL;DR: It is demonstrated that many miRNAs are engaged in the resistance of cancer therapies with their complex underlying regulatory mechanisms, whose comprehensive cognition can help clinicians and improve patient prognosis.
Journal ArticleDOI
Plant RNases T2, but not Dicer-like proteins, are major players of tRNA-derived fragments biogenesis.
Cyrille Megel,Guillaume Hummel,Stéphanie Lalande,Elodie Ubrig,Valérie Cognat,Geoffrey Morelle,Thalia Salinas-Giegé,Anne-Marie Duchêne,Laurence Maréchal-Drouard +8 more
TL;DR: It is demonstrated that the Arabidopsis RNases T2, called RNS, are key players of both long and short tRFs biogenesis, and an evolutionary conserved feature of these enzymes in eukaryotes is suggested.
Journal ArticleDOI
Development of miRNA-based therapeutic approaches for cancer patients.
TL;DR: Recent progress in the development of miRNA therapeutics for the treatment of cancer patients is summarized, and delivery systems for oligonucleotide therapeutics are described.
Journal ArticleDOI
Drosophila tsRNAs preferentially suppress general translation machinery via antisense pairing and participate in cellular starvation response.
TL;DR: The study suggests the tsRNA-mediated regulation might be crucial for the energy homeostasis and the metabolic adaptation in the cellular systems.