Fatty Acid Synthase and Cancer: New Application of an Old Pathway
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TLDR
FAS is associated with poor prognosis in breast and prostate cancer, is elaborated into the blood of cancer patients, and its inhibition is selectively cytotoxic to human cancer cells.Abstract:
Fatty acid synthase (FAS), the sole mammalian enzyme capable of de novo fatty acid synthesis, is highly expressed in most human carcinomas. FAS is associated with poor prognosis in breast and prostate cancer, is elaborated into the blood of cancer patients, and its inhibition is selectively cytotoxic to human cancer cells. Thus, FAS and fatty acid metabolism in cancer has become a focus for the potential diagnosis and treatment of cancer.read more
Citations
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Journal ArticleDOI
Fatty acid synthase and the lipogenic phenotype in cancer pathogenesis
Javier A. Menendez,Ruth Lupu +1 more
TL;DR: FASN, a nearly-universal druggable target in many human carcinomas and their precursor lesions, offers new therapeutic opportunities for metabolically treating and preventing cancer.
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Lipid metabolic reprogramming in cancer cells
TL;DR: In it, detailed insight is provided into the essential roles exerted by specific lipids in mediating intracellular oncogenic signaling, endoplasmic reticulum stress and bidirectional crosstalk between cells of the tumor microenvironment and cancer cells.
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De novo Lipogenesis Protects Cancer Cells from Free Radicals and Chemotherapeutics by Promoting Membrane Lipid Saturation
Evelien Rysman,Koen Brusselmans,Katryn Scheys,Leen Timmermans,Rita Derua,Sebastian Munck,Paul P. Van Veldhoven,David Waltregny,Veerle W. Daniels,Jelle Machiels,Frank Vanderhoydonc,Karine Smans,Etienne Waelkens,Guido Verhoeven,Johannes V. Swinnen +14 more
TL;DR: Evidence is provided that shifting lipid acquisition from lipid uptake toward de novo lipogenesis dramatically changes membrane properties and protects cells from both endogenous and exogenous insults, and provides a rationale for the use of lipogenesis inhibitors as antineoplastic agents and as chemotherapeutic sensitizers.
Journal ArticleDOI
Fatty acid synthase as a potential therapeutic target in cancer
TL;DR: Overexpression of FASN is common in many cancers, and accumulating evidence suggests that it is a metabolic oncogene with an important role in tumor growth and survival, making it an attractive target for cancer therapy.
Journal ArticleDOI
Metformin in cancer therapy: a new perspective for an old antidiabetic drug?
TL;DR: There is increasing evidence of a potential efficacy of this agent as an anticancer drug, and several reports outline a direct inhibitory effect of metformin on cancer cell growth and an antitumoral action.
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Fatty-acid synthase and human cancer: new perspectives on its role in tumor biology.
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Journal ArticleDOI
Fatty acid synthesis: a potential selective target for antineoplastic therapy
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TL;DR: Tumor cell lines with elevated fatty acid synthase showed commensurate increases in incorporation of [U-14C]acetate into acylglycerols demonstrating that fatty acids synthase increases occur in the context of overall increases in endogenous fatty acid synthesis.
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Fatty acid synthase and the lipogenic phenotype in cancer pathogenesis
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