Lipid metabolic reprogramming in cancer cells
S Beloribi-Djefaflia,Sophie Vasseur,Fabienne Guillaumond +2 more
- Vol. 5, Iss: 1
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TLDR
In it, detailed insight is provided into the essential roles exerted by specific lipids in mediating intracellular oncogenic signaling, endoplasmic reticulum stress and bidirectional crosstalk between cells of the tumor microenvironment and cancer cells.Abstract:
Many human diseases, including metabolic, immune and central nervous system disorders, as well as cancer, are the consequence of an alteration in lipid metabolic enzymes and their pathways. This illustrates the fundamental role played by lipids in maintaining membrane homeostasis and normal function in healthy cells. We reviewed the major lipid dysfunctions occurring during tumor development, as determined using systems biology approaches. In it, we provide detailed insight into the essential roles exerted by specific lipids in mediating intracellular oncogenic signaling, endoplasmic reticulum stress and bidirectional crosstalk between cells of the tumor microenvironment and cancer cells. Finally, we summarize the advances in ongoing research aimed at exploiting the dependency of cancer cells on lipids to abolish tumor progression.read more
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Reprogramming of fatty acid metabolism in cancer
TL;DR: This review will examine the mechanisms through which cancer cells rewire their fatty acid metabolism with a focus on four main areas of research, including the role of de novo synthesis and exogenous uptake in the cellular pool of fatty acids.
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SREBP-regulated lipid metabolism: convergent physiology - divergent pathophysiology.
Hitoshi Shimano,Ryuichiro Sato +1 more
TL;DR: This Review aims to provide a comprehensive understanding of the role of SREBPs in physiology and pathophysiology at the cell, organ and organism levels.
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Progress in tumor-associated macrophage (TAM)-targeted therapeutics
TL;DR: This review aims to introduce readers to various aspects in development and evaluation of TAM-targeted therapeutics in pre-clinical and clinical stages of cancer immunotherapies targeting tumor-associated macrophages.
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Extracellular ATP and P2 purinergic signalling in the tumour microenvironment
TL;DR: How extracellular ATP and P2 purinergic signalling can shape the tumour microenvironment to both promote and restrain tumour progression is described and the opportunities to harness nucleotide receptor signalling as an anticancer strategy are outlined.
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Membrane Lipid Composition: Effect on Membrane and Organelle Structure, Function and Compartmentalization and Therapeutic Avenues.
TL;DR: The therapeutic potential of manipulating membrane lipid composition with approaches like membrane lipid therapy, aiming to normalize cell functions through the modification of membrane lipid bilayers is explored.
References
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Journal ArticleDOI
Hallmarks of cancer: the next generation.
TL;DR: Recognition of the widespread applicability of these concepts will increasingly affect the development of new means to treat human cancer.
Journal ArticleDOI
Lipid Rafts As a Membrane-Organizing Principle
Daniel Lingwood,Kai Simons +1 more
TL;DR: The evidence for how this principle combines the potential for sphingolipid-cholesterol self-assembly with protein specificity to selectively focus membrane bioactivity is reviewed.
Journal ArticleDOI
Accessories to the Crime: Functions of Cells Recruited to the Tumor Microenvironment
Douglas Hanahan,Lisa M. Coussens +1 more
TL;DR: Most of the hallmarks of cancer are enabled and sustained to varying degrees through contributions from repertoires of stromal cell types and distinctive subcell types, which presents interesting new targets for anticancer therapy.
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