Journal ArticleDOI
Flavonoids-potent and versatile biologically active compounds interacting with cytochromes P450
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TLDR
Flavonoids show an estrogenic or anti-estrogenic activity owing to the structural similarity with the estrogen skeleton, and may reduce the risk of various cancers, especially hormone-dependent breast and prostate cancers, as well preventing menopausal symptoms.About:
This article is published in Chemico-Biological Interactions.The article was published on 2002-01-22. It has received 640 citations till now.read more
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Flavonoid antioxidants: chemistry, metabolism and structure-activity relationships.
TL;DR: The diversity and multiple mechanisms of flavonoid action, together with the numerous methods of initiation, detection and measurement of oxidative processes in vitro and in vivo offer plausible explanations for existing discrepancies in structure-activity relationships.
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Plant phenolics: extraction, analysis and their antioxidant and anticancer properties.
Jin Dai,Russell J. Mumper +1 more
TL;DR: The anticancer effects of phenolics in-vitro and in- vivo animal models are viewed, including recent human intervention studies, and possible mechanisms of action involving antioxidant and pro-oxidant activity as well as interference with cellular functions are discussed.
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Potential toxicity of flavonoids and other dietary phenolics: significance for their chemopreventive and anticancer properties.
Giuseppe Galati,Peter J. O'Brien +1 more
TL;DR: The current knowledge regarding potential dietary flavonoid/phenolic-induced toxicity concerns, including their pro-oxidant activity, mitochondrial toxicity (potential apoptosis-inducing properties), and interactions with drug-metabolizing enzymes are summarized.
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Update on uses and properties of citrus flavonoids: new findings in anticancer, cardiovascular, and anti-inflammatory activity.
TL;DR: The relation between each structural factor of Citrus flavonoids and the anticancer, anti-inflammatory, and cardiovascular protection activity of Citron flavonoid and their role in degenerative diseases are discussed.
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Dietary flavonoids: effects on xenobiotic and carcinogen metabolism.
TL;DR: The cancer protective effects of flavonoids have been attributed to a wide variety of mechanisms, including modulating enzyme activities resulting in the decreased carcinogenicity of xenobiotics and phase II enzymes, largely responsible for the detoxification of carcinogens.
References
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Flavonoids as Antioxidants
TL;DR: This review presents the current knowledge on structural aspects and in vitro antioxidant capacity of most common flavonoids as well as in vivo antioxidant activity and effects on endogenous antioxidants.
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Polyphenols: Chemistry, Dietary Sources, Metabolism, and Nutritional Significance
TL;DR: An overview of the nutritional effects of the main groups of polyphenolic compounds, including their metabolism, effects on nutrient bioavailability, and antioxidant activity, is offered, as well as a brief description of the chemistry ofpolyphenols and their occurrence in plant foods.
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Adipose Tissue as an Endocrine Organ
Rexford S. Ahima,Jeffery S Flier +1 more
TL;DR: The discovery of leptin in the mid-1990s has focused attention on the role of proteins secreted by adipose tissue, which is also involved in the regulation of neuroendocrine and immune function and the metabolic and cardiovascular complications associated with obesity.
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Legumes and soybeans: overview of their nutritional profiles and health effects
TL;DR: Nutritionists should make a concerted effort to encourage the public to consume more beans in general and more soyfoods in particular to reduce the risk of osteoporosis.
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Inhibition and Induction of Cytochrome P450 and the Clinical Implications
Jiunn H. Lin,Anthony Y.H. Lu +1 more
TL;DR: T careful evaluation of potential drug interactions of a new drug candidate during the early stage of drug development is essential, because the smaller the difference between toxic and effective concentration, the greater the likelihood that a drug interaction will have serious clinical consequences.