Journal ArticleDOI
Fluorescent probes and bioimaging: alkali metals, alkaline earth metals and pH
TLDR
This review highlights the recent advances that have been made in the design and bioimaging applications of fluorescent probes for alkali metals and alkaline earth metal cations, including lithium, sodium and potassium, magnesium and calcium, and for pH determination within biological systems.Abstract:
All living species and life forms have an absolute requirement for bio-functional metals and acid–base equilibrium chemistry owing to the critical roles they play in biological processes. Hence, a great need exists for efficient methods to detect and monitor biometals and acids. In the last few years, great attention has been paid to the development of organic molecule based fluorescent chemosensors. The availability of new synthetic fluorescent probes has made fluorescence microscopy an indispensable tool for tracing biologically important molecules and in the area of clinical diagnostics. This review highlights the recent advances that have been made in the design and bioimaging applications of fluorescent probes for alkali metals and alkaline earth metal cations, including lithium, sodium and potassium, magnesium and calcium, and for pH determination within biological systems.read more
Citations
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Recent Development of Chemosensors Based on Cyanine Platforms
TL;DR: This review focuses on the development from 2000 to 2015 of cyanine, hemicyanine, and squaraine sensors, and emphasizes the advances that have been made in improving the detection performance through incorporation of the chemosensors into nanoparticles.
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Metal Sensing by DNA
TL;DR: Each metal ion and the known DNA sequences for its sensing are reviewed and the fundamental aspect of metal binding is emphasized, emphasizing the distinct chemical property of each metal.
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Fluorescent chemical probes for accurate tumor diagnosis and targeting therapy
TL;DR: The progress in chemical probes described here suggests that fluorescence imaging is a vital and rapidly developing field for interventional surgical imaging, as well as tumor diagnosis and therapy.
Journal ArticleDOI
The triplet excited state of Bodipy: formation, modulation and application
TL;DR: The methods for switching (or modulation) of the triplet excited state of Bodipy were discussed, such as those based on the photo-induced electron transfer (PET), by controlling the competing Förster-resonance-energy-transfer (FRET), or the intermolecular charge transfer (ICT).
Journal ArticleDOI
Long-Lived Emissive Probes for Time-Resolved Photoluminescence Bioimaging and Biosensing
TL;DR: The design and applications of various kinds of long-lived emissive probes for bioimaging and biosensing via time-resolved photoluminescence techniques are summarized and the imaging contrast and sensing sensitivity are remarkably improved.
References
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Signaling Recognition Events with Fluorescent Sensors and Switches.
A. Prasanna de Silva,H. Q. Nimal Gunaratne,Thorfinnur Gunnlaugsson,Allen J. M. Huxley,Colin P. McCoy,Jude T. Rademacher,Terence E. Rice +6 more
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Deep tissue two-photon microscopy
Fritjof Helmchen,Winfried Denk +1 more
TL;DR: Fundamental concepts of nonlinear microscopy are reviewed and conditions relevant for achieving large imaging depths in intact tissue are discussed.
Journal ArticleDOI
Nonlinear magic: multiphoton microscopy in the biosciences
TL;DR: Multiphoton microscopy has found a niche in the world of biological imaging as the best noninvasive means of fluorescence microscopy in tissue explants and living animals and its use is now increasing exponentially.
Journal ArticleDOI
New calcium indicators and buffers with high selectivity against magnesium and protons: design, synthesis, and properties of prototype structures.
TL;DR: The compounds described are fluorescent Ca2+ indicators absorbing in the ultraviolet region; the very large spectral shifts observed on binding Ca2+, fit the prediction that complexation should hinder the conjugation of the nitrogen lone-pair electrons with the aromatic rings.