Journal ArticleDOI
Functional consequences of the phosphorylation of the gonadotropin receptors
TLDR
In this paper, recent studies from my laboratory designed to directly address the potential involvement of gonadotropin receptor phosphorylation in the process of uncoupling have been reviewed.About:
This article is published in Biochemical Pharmacology.The article was published on 1996-12-13. It has received 21 citations till now. The article focuses on the topics: Insulin-like growth factor 1 receptor & Receptor.read more
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Journal ArticleDOI
The follicle-stimulating hormone receptor: biochemistry, molecular biology, physiology, and pathophysiology.
TL;DR: This work presents a detailed description of the structure-function relationships and models of FSH-FSH Receptor interaction, and some of the mechanisms behind the interaction between the FSH and FSH receptor have been described.
Journal ArticleDOI
Activation of Extracellular-regulated Kinase Pathways in Ovarian Granulosa Cells by the Novel Growth Factor Type 1 Follicle-stimulating Hormone Receptor: ROLE IN HORMONE SIGNALING AND CELL PROLIFERATION
TL;DR: Alternative splicing of a G-protein coupled receptor creates the expression of a novel receptor motif that can mediate a widely recognized function of the glycoprotein hormone.
Journal ArticleDOI
Short term feedback regulation of cAMP in FRTL-5 thyroid cells. Role of PDE4D3 phosphodiesterase activation.
TL;DR: Evidence is provided that a rapid activation of PDE4D3 is one of the mechanisms determining the intensity of the cAMP signal.
Journal ArticleDOI
A clinical study of 22.5 mg. La-2550: A new subcutaneous depot delivery system for leuprolide acetate for the treatment of prostate cancer.
TL;DR: LA-2550 (22.5 mg. depot) produced and maintained safe and effective suppression of serum testosterone to well below the medical castrate level of 50 ng./dl.
Journal ArticleDOI
A 12-Month Clinical Study of LA-2585 (45.0 MG): A New 6-Month Subcutaneous Delivery System for Leuprolide Acetate for the Treatment of Prostate Cancer
TL;DR: LA-2585 consistently produced and maintained safe and effective serum testosterone suppression with total serum testosterone well below the medical castrate level of less than 50 ng/dl.
References
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Journal ArticleDOI
Molecular cloning of a functional thrombin receptor reveals a novel proteolytic mechanism of receptor activation.
TL;DR: A novel signaling mechanism in which thrombin cleaves its receptor's amino-terminal extension to create a new receptor amino terminus that functions as a tethered ligand and activates the receptor is revealed.
Journal ArticleDOI
Model systems for the study of seven-transmembrane-segment receptors.
TL;DR: This paper presents a meta-analyses of the chiral signaling process and its applications in medicine and animal welfare, and investigates the role of chiral reprograming in the development of Alzheimer's disease.
Journal ArticleDOI
Turning off the signal: desensitization of beta-adrenergic receptor function.
TL;DR: The molecular mechanisms underlying rapid βAR desensitization do not appear to require internalization of the receptors, but rather an alteration in the functioning of βAR themselves that uncouples the receptors from the stimulatory G protein Gs.
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Structure and Function of G Protein-Coupled Receptors
TL;DR: This chapter discusses the construction of the Peptide-Binding Site, the binding site for Nonpeptide Antagonists, and the role of phosphorous in the biosynthetic pathway.
Journal ArticleDOI
Lutropin-choriogonadotropin receptor: an unusual member of the G protein-coupled receptor family.
Keith C Mcfarland,Rolf Sprengel,Heidi S. Phillips,Martin Köhler,Nora Rosemblit,Karoly Nikolics,Deborah L. Segaloff,Peter H. Seeburg +7 more
TL;DR: The LH-CG-R gene may have evolved by recombination of LRG and G protein-coupled receptor genes and bind human choriogonadotropin with high affinity and show an increase in cyclic adenosine monophosphate when exposed to hormone.