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Open AccessJournal ArticleDOI

Functional Data Analysis

TLDR
In this article, the authors provide an overview of FDA, starting with simple statistical notions such as mean and covariance functions, then covering some core techniques, the most popular of which is functional principal component analysis (FPCA).
Abstract
With the advance of modern technology, more and more data are being recorded continuously during a time interval or intermittently at several discrete time points. These are both examples of functional data, which has become a commonly encountered type of data. Functional data analysis (FDA) encompasses the statistical methodology for such data. Broadly interpreted, FDA deals with the analysis and theory of data that are in the form of functions. This paper provides an overview of FDA, starting with simple statistical notions such as mean and covariance functions, then covering some core techniques, the most popular of which is functional principal component analysis (FPCA). FPCA is an important dimension reduction tool, and in sparse data situations it can be used to impute functional data that are sparsely observed. Other dimension reduction approaches are also discussed. In addition, we review another core technique, functional linear regression, as well as clustering and classification of functional d...

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Citations
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Journal ArticleDOI

A general framework for functional regression modelling

TL;DR: A comprehensive framework for additive (mixed) models for functional responses and/or functional covariates based on the guiding principle of reframing functional regression in terms of corresponding models for scalar data is discussed, allowing the adaptation of a large body of existing methods for these novel tasks.
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Dimensionality reduction of diffusion MRI measures for improved tractometry of the human brain

TL;DR: It is demonstrated that dMRI analyses can benefit from dimensionality reduction techniques, to help disentangling the neurobiological underpinnings of white matter organisation.
Journal ArticleDOI

Grouped functional time series forecasting: An application to age-specific mortality rates

TL;DR: In this article, the authors proposed a bootstrap method for reconciling interval forecasts of age-specific mortality rates, where age is considered as a continuum and grouped functional time series methods were used to produce point forecasts of mortality rates that are aggregated appropriately across different disaggregation factors.
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Nonparametric Analysis of Thermal Proteome Profiles Reveals Novel Drug-binding Proteins.

TL;DR: Nonparametric analysis of response curves (NPARC), a statistical method for TPP based on functional data analysis and nonlinear regression, is presented and observed that it is able to detect subtle changes in any region of the melting curves, reliably detects the known targets, and outperforms a melting point-centric, single-parameter fitting approach in terms of specificity and sensitivity.
References
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Journal ArticleDOI

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TL;DR: Locally linear embedding (LLE) is introduced, an unsupervised learning algorithm that computes low-dimensional, neighborhood-preserving embeddings of high-dimensional inputs that learns the global structure of nonlinear manifolds.
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A global geometric framework for nonlinear dimensionality reduction.

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Generalized Additive Models.

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Dynamic programming algorithm optimization for spoken word recognition

TL;DR: This paper reports on an optimum dynamic progxamming (DP) based time-normalization algorithm for spoken word recognition, in which the warping function slope is restricted so as to improve discrimination between words in different categories.
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Generalized Additive Models

TL;DR: The class of generalized additive models is introduced, which replaces the linear form E fjXj by a sum of smooth functions E sj(Xj), and has the advantage of being completely auto- matic, i.e., no "detective work" is needed on the part of the statistician.