Book ChapterDOI
Functional Polymorphism of Alcohol and Aldehyde Dehydrogenases: Alcohol Metabolism, Alcoholism, and Alcohol- Induced Organ Damage
Shih-Jiun Yin,Dharam P. Agarwal +1 more
- pp 15-40
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The article was published on 2001-06-01. It has received 41 citations till now. The article focuses on the topics: Aldehyde dehydrogenase.read more
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Journal ArticleDOI
Less drinking, yet more problems: Understanding African American drinking and related problems.
TL;DR: A theory is provided that there appears to be one particular group of African Americans, low-income African American men, who are at the highest risk for alcoholism and related problems, and this effect is due to the complex interaction of residential discrimination, racism, age of drinking, and lack of available standard life reinforcers.
Journal ArticleDOI
Meta-Analyses of ALDH2 and ADH1B with Alcohol Dependence in Asians.
TL;DR: Meta-analyses were conducted to determine the magnitude of relationships between polymorphisms in 2 genes, ALDH2 and ADH1B, with alcohol dependence in Asians, and possession of 1 variant *2 allele was protective against alcohol dependence.
Journal ArticleDOI
Associations of ADH and ALDH2 gene variation with self report alcohol reactions, consumption and dependence: an integrated analysis
Stuart MacGregor,Penelope A. Lind,Kathleen K. Bucholz,Narelle K. Hansell,Pamela A. F. Madden,Melinda M. Richter,Grant W. Montgomery,Nicholas G. Martin,Andrew C. Heath,John Whitfield +9 more
TL;DR: Results bridge the gap between DNA sequence variation and alcohol- related behavior, confirming that the ADH1B-Arg48His polymorphism affects both alcohol-related flushing in Europeans and alcohol intake.
Journal ArticleDOI
Effect of the allelic variants of aldehyde dehydrogenase ALDH2*2 and alcohol dehydrogenase ADH1B*2 on blood acetaldehyde concentrations
Giia-Sheun Peng,Shih-Jiun Yin +1 more
TL;DR: This paper illustrates a paradigmatic example of phenotypic verifications in a protective disease gene for substance abuse with an emphasis on the pharmacogenetic consequences of venous blood acetaldehyde in the different ALDH2 genotypes following the intake of various doses of ethanol.
Journal ArticleDOI
Functional assessment of human alcohol dehydrogenase family in ethanol metabolism: significance of first-pass metabolism.
TL;DR: It was assessed that livers withADH1B*1 may eliminate approximately 95% or more of single-passed ethanol as inflow sinusoidal alcohol reaches approximately 1 mM and that stomachs with different ADH1C genotypes may remove 20% to 30% of single -passed alcohol at the similar level in mucosal cells.
References
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Journal ArticleDOI
Neurogenetic adaptive mechanisms in alcoholism
TL;DR: In this paper, three dimensions of personality have been described that may reflect individual differences in brain systems modulating the activation, maintenance, and inhibition of behavioral responses to the effects of alcohol and other environmental stimuli.
Journal ArticleDOI
Genome‐wide search for genes affecting the risk for alcohol dependence
Theodore Reich,Howard J. Edenberg,Alison Goate,Jeff T. Williams,John P. Rice,Paul Van Eerdewegh,Tatiana Foroud,Victor Hesselbrock,Marc A. Schuckit,Kathleen K. Bucholz,Bernice Porjesz,Ting-Kai Li,P. Michael Conneally,John I. Nurnberger,Jay A. Tischfield,Raymond R. Crowe,C. Robert Cloninger,William Wu,Shantia Shears,Kristie Carr,Candice Crose,Chris Willig,Henri Begleiter +22 more
TL;DR: There was suggestive evidence for a protective locus on chromosome 4 near the alcohol dehydrogenase genes, for which protective effects have been reported in Asian populations.
Journal Article
Alcohol and aldehyde dehydrogenase genotypes and alcoholism in Chinese men.
Holly R. Thomasson,Howard J. Edenberg,David W. Crabb,Xiao Ling Mai,Ronald E. Jerome,Ting-Kai Li,Shiou Ping Wang,Yu Tsai Lin,Ru Band Lu,Shin Jiun Yin +9 more
TL;DR: The genotypes of the ADH2, ADH3, and ALDH2 loci of alcoholic and nonalcoholic Chinese men living in Taiwan are determined using leukocyte DNA amplified by the PCR and allele-specific oligonucleotides, suggesting that genetic variation in both ADH and AL DH, by modulating the rate of metabolism of ethanol and acetaldehyde, influences drinking behavior and the risk of developing alcoholism.
Journal ArticleDOI
Genotypes for aldehyde dehydrogenase deficiency and alcohol sensitivity. The inactive ALDH2(2) allele is dominant.
TL;DR: The polymerase chain reaction is used to determine the genotypes of 24 livers from Japanese individuals and it is concluded that the allele (ALDH2(2)) encoding the abnormal subunit is dominant.
Journal ArticleDOI
Aldehyde dehydrogenase deficiency as cause of facial flushing reaction to alcohol in japanese
TL;DR: This commentary examines only the enzyme (designated as ALDH2) that is imported into the mitochondrion, the cell’s energy producing structure that is key in the metabolism of acetaldehyde produced after alco hol consumption.
Related Papers (5)
Genetic polymorphism of alcohol dehydrogenase in europeans: the ADH2*2 allele decreases the risk for alcoholism and is associated with ADH3*1.
Emma Borràs,Christiane Coutelle,Albert Rosell,Fina Fernández-Muixi,Montserrat Broch,Bernat Crosas,Lars Hjelmqvist,Alfons Lorenzo,Cristina Gutierrez,Mauro Santos,Małgorzata Szczepanek,Markus Heilig,Pierrette Quattrocchi,Jaume Farrés,Francesc Vidal,Cristóbal Richart,Tomasz Mach,Bogdał J,Hans Jörnvall,Helmut K. Seitz,Patrice Couzigou,Xavier Parés +21 more