Functional signature of recovering cortex: dissociation of local field potentials and spiking activity in somatosensory cortices of spinal cord injured monkeys.
TLDR
It is suggested that the failure to generate spiking activity at high stimulus frequency reflects a changed balance of inhibition and excitation in both area 3b and S2, and that this mismatch in spiking and local field potential is a signature of an early phase of recovering cortex.About:
This article is published in Experimental Neurology.The article was published on 2013-11-01 and is currently open access. It has received 15 citations till now. The article focuses on the topics: Sensory stimulation therapy & Premovement neuronal activity.read more
Citations
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Journal ArticleDOI
The reactivation of somatosensory cortex and behavioral recovery after sensory loss in mature primates.
TL;DR: It is concluded that preserved dorsal column afferents after nearly complete lesions contribute to the reactivation of cortex and the recovery of the behavior, but second-order sensory pathways in the spinal cord may also play an important role.
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Spinal cord neuron inputs to the cuneate nucleus that partially survive dorsal column lesions: A pathway that could contribute to recovery after spinal cord injury.
TL;DR: A small second‐order pathway to the cuneate nucleus that survives high cervical dorsal column lesions by traveling in the lateral funiculus is revealed, which could be important for cortical reactivation by hand afferents, and recovery of hand use.
Journal ArticleDOI
Intrinsic functional architecture of the non-human primate spinal cord derived from fMRI and electrophysiology
Tung Lin Wu,Pai Feng Yang,Pai Feng Yang,Feng Wang,Feng Wang,Zhaoyue Shi,Arabinda Mishra,Arabinda Mishra,Ruiqi Wu,Li Min Chen,Li Min Chen,John C. Gore +11 more
TL;DR: The authors show that fMRI corresponds well to electrophysiological measures of spinal cord activity, suggesting that there is an intrinsic functional architecture within the gray matter of a single spinal segment, and that rsfMRI signals at high field directly reflect this underlying spontaneous neuronal activity.
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Cortical neuron response properties are related to lesion extent and behavioral recovery after sensory loss from spinal cord injury in monkeys.
TL;DR: It is proposed that alternate spinal afferents, in addition to the few spared primary axon afferentS in the dorsal columns, likely have a major role in the reactivation pattern and return of function in lesion and control monkeys.
Journal ArticleDOI
Parallel Functional Reorganizations of Somatosensory Areas 3b and 1, and S2 following Spinal Cord Injury in Squirrel Monkeys
TL;DR: The data show that more severe afferent disruption was associated with greater cortical plasticity and behavioral impairment, and reorganization that occurred in area 3b, area 1, and S2 were similar across most measures.
References
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Neurophysiological investigation of the basis of the fMRI signal
TL;DR: These findings suggest that the BOLD contrast mechanism reflects the input and intracortical processing of a given area rather than its spiking output, and that LFPs yield a better estimate of BOLD responses than the multi-unit responses.
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Abnormal neural oscillations and synchrony in schizophrenia
TL;DR: Dysfunctional oscillations may arise owing to anomalies in the brain's rhythm-generating networks of GABA (γ-aminobutyric acid) interneurons and in cortico-cortical connections.
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Phantom-limb pain as a perceptual correlate of cortical reorganization following arm amputation
Herta Flor,Thomas Elbert,Stefan Knecht,Christian Wienbruch,Christo Pantev,Niels Birbaumer,Wolfgang Larbig,Edward Taub +7 more
TL;DR: A very strong direct relationship is reported between the amount of cortical reorganization and the magnitude of phantom limb pain (but not non-painful phantom phenomena) experienced after arm amputation, indicating that phantom-limb pain is related to, and may be a consequence of, plastic changes in primary somatosensory cortex.
Book
Human Brain Electrophysiology: Evoked Potentials and Evoked Magnetic Fields in Science and Medicine
TL;DR: In this article, the authors propose an approach to explore the potential of PE in the context of neurophysiologie and psychophysics, and propose a set of criteria for evaluating the applicability of PE.
Journal ArticleDOI
An oscillatory hierarchy controlling neuronal excitability and stimulus processing in the auditory cortex
Peter Lakatos,Ankoor S. Shah,Kevin H. Knuth,István Ulbert,George Karmos,Charles E. Schroeder +5 more
TL;DR: It is proposed that the hierarchical organization of ambient oscillatory activity allows auditory cortex to structure its temporal activity pattern so as to optimize the processing of rhythmic inputs.