GABAergic Interneurons: Implications for Understanding Schizophrenia and Bipolar Disorder
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TLDR
Investigation of the GABA system in rodent, primate and human brain and the characterization of changes in specific phenotypic subclasses of interneurons in schizophrenia and bipolar disorder will undoubtedly provide important new insights into how the integration of this transmitter system may be altered in neuropsychiatric disease.About:
This article is published in Neuropsychopharmacology.The article was published on 2001-07-01 and is currently open access. It has received 1063 citations till now. The article focuses on the topics: GABAergic & Interneuron.read more
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Cortical inhibitory neurons and schizophrenia
TL;DR: Convergent findings indicate that a deficiency in signalling through the TrkB neurotrophin receptor leads to reduced GABA synthesis in the parvalbumin-containing subpopulation of inhibitory GABA neurons in the dorsolateral prefrontal cortex of individuals with schizophrenia.
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The principal features and mechanisms of dopamine modulation in the prefrontal cortex
TL;DR: Certain principles of DA mechanisms are identified by drawing on published, as well as unpublished data from PFC and other CNS sites to shed light on aspects of DA neuromodulation and address some of the existing controversies.
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Epigenetic Regulations of GABAergic Neurotransmission: Relevance for Neurological Disorders and Epigenetic Therapy
TL;DR: How various genetic and epigenetic events regulate the GABAergic genes in pre- and postnatal brain contribute to the pathogenesis of neurological disorders and can be used in the development of potential epigenetic therapy for these diseases.
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Interneuron dysfunction in psychiatric disorders
TL;DR: In conclusion, animal models demonstrate that the molecular basis of disruption is linked to specific defects in the development and function of interneurons — the cells that are responsible for establishing inhibitory circuits in the brain.
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The origin and specification of cortical interneurons
TL;DR: Recent data that are beginning to illuminate the origins and specification of distinct subgroups of cortical interneurons are discussed.
References
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The Selective innervation by serotoninergic axons of calbindin‐containing interneurons in the neocortex and hippocampus of the marmoset
TL;DR: This study has searched for specific markers characterizing the neurons of the marmoset neocortex and hippocampus surrounded by these thick varicose serotonin‐containing fibers and found this organization was found in all areas of the neoc cortex and of the hippocampus where serotonin‐ containing baskets were present.
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Low-threshold transient calcium current in rat hippocampal lacunosum-moleculare interneurons: kinetics and modulation by neurotransmitters.
TL;DR: Interneurons from the CA1 lacunosum-moleculare (L-M) region were isolated by trypsin-hyaluronidase treatment and mechanical trituration and showed multipolar with several dendritic processes and could be distinguished from CA1 pyramidal neurons.
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Distribution of glutamate decarboxylase65 immunoreactive puncta on pyramidal and nonpyramidal neurons in hippocampus of schizophrenic brain
TL;DR: This study provides further evidence in support of the hypothesis that an intrinsic defect of GABAergic activity may occur in the hippocampal formation of schizophrenic patients and show dose‐related increases in relation to neuroleptic exposure.
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The postnatal development of the benzodiazepine receptor in the cerebral cortex and cerebellum of the rat.
J. M. Candy,I. L. Martin +1 more
TL;DR: The present report is concerned with the postnatal development of these benzodiazepine-binding sites in the cerebral cortex and cerebellum of the rat and hoped that correlation of the time course of development of the benzidiazepine receptor with neuronal development might shed some light on the localisation of this receptor.
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Dopamnine‐Immunoreactive axon varicosities form nonrandom contacts with GABA‐immunoreactive neurons of rat medial prefrontal cortex
TL;DR: The results confirm studies from other laboratories showing a rich network of dopamine‐immunoreactive fibers forming a gradient across the cortical laminae, with deeper layers having the highest density and suggest that inhibitory interneurons can play a direct role in mediating the effects of midbrain dopamine afferents in rat medial prefrontal cortex.