GABAergic Interneurons: Implications for Understanding Schizophrenia and Bipolar Disorder
Reads0
Chats0
TLDR
Investigation of the GABA system in rodent, primate and human brain and the characterization of changes in specific phenotypic subclasses of interneurons in schizophrenia and bipolar disorder will undoubtedly provide important new insights into how the integration of this transmitter system may be altered in neuropsychiatric disease.About:
This article is published in Neuropsychopharmacology.The article was published on 2001-07-01 and is currently open access. It has received 1063 citations till now. The article focuses on the topics: GABAergic & Interneuron.read more
Citations
More filters
Reference EntryDOI
Dopamine and Glutamate Hypotheses of Schizophrenia
Bita Moghaddam,Houman Homayoun +1 more
TL;DR: The dopamine hypothesis of schizophrenia predicts that a disrupted glutamatergic transmission causes the core cognitive deficits of schizophrenia and may lead to a secondary disruption in dopamine transmission that in turn causes psychosis.
Journal Article
La Corteza cerebral más allá de la corteza
Pimienta J,Hernán José +1 more
TL;DR: Agarwal et al. as mentioned in this paper define a sistema complejo de fibras cortico-corticales, comisuralesy de proyeccion constituyen the salida de cada modulo hacia otras areas corticales o estruc-tura subcortices; de esta manera, la corteza cerebral controla el pensamiento, la conciencia, la atencion, la memoria, el lenguaje, actividad motora, las
Journal ArticleDOI
Immunohistochemical visualization of mouse interneuron subtypes.
Simon Molgaard,Maj Ulrichsen,Simon Boggild,Marie Louise Holm,Christian Bjerggaard Vaegter,Jens R. Nyengaard,Simon Glerup,Simon Glerup +7 more
TL;DR: A journey to find the necessary immunological reagents for studying GABAergic interneurons of the mouse hippocampus was described, finding antibodies with a high rating on pAbmAbs, stainings with high signal-to-noise ratios and location of the immunostained cells in accordance with the literature could be obtained, making these antibodies suitable choices for studying the GABAergic system.
Book ChapterDOI
Neurosteroid Perturbation and Neuropsychiatric Symptoms in Schizophrenia: From the Mechanisms to the Treatment
TL;DR: This chapter summarizes the current understanding of these neurosteroids in schizophrenia, their potential antipsychotic role, and discusses new avenues for this area of schizophrenia research.
References
More filters
Journal ArticleDOI
Cholinergic innervation of cortex by the basal forebrain : cytochemistry and cortical connections of the septal area, diagonal band nuclei, nucleus basalis (substantia innominata), and hypothalamus in the rhesus monkey
TL;DR: The organization of projections from the cholinergic neurons of the basal forebrain to neocortex and associated structures was investigated in the rhesus monkey with the help of horseradish peroxidase transport, acetyl‐cholinesterase histochemistry, and choline acetyltransferase immunohis‐tochemistry.
Journal ArticleDOI
Synchronized oscillations in interneuron networks driven by metabotropic glutamate receptor activation
TL;DR: It is proposed that interneuron network oscillations, in conjunction with intrinsic membrane resonances and long-loop (such as thalamocortical) interactions, contribute to 40-Hz rhythms in vivo.
Journal ArticleDOI
Gamma (40-100 Hz) oscillation in the hippocampus of the behaving rat
TL;DR: It is suggested that gamma oscillation emerges from an interaction between intrinsic oscillatory properties of interneurons and the network properties of the dentate gyrus and that Gamma oscillation in the CA3-CA1 circuitry is suppressed by either the hilar region or the entorhinal cortex.
Journal ArticleDOI
Two networks of electrically coupled inhibitory neurons in neocortex
TL;DR: Two functionally distinct inhibitory networks comprising either fast-spiking (FS) or low-threshold spiking (LTS) neurons are described, which may allow each inhibitory network to function independently.