GABAergic Interneurons: Implications for Understanding Schizophrenia and Bipolar Disorder
Reads0
Chats0
TLDR
Investigation of the GABA system in rodent, primate and human brain and the characterization of changes in specific phenotypic subclasses of interneurons in schizophrenia and bipolar disorder will undoubtedly provide important new insights into how the integration of this transmitter system may be altered in neuropsychiatric disease.About:
This article is published in Neuropsychopharmacology.The article was published on 2001-07-01 and is currently open access. It has received 1063 citations till now. The article focuses on the topics: GABAergic & Interneuron.read more
Citations
More filters
Book ChapterDOI
An Overview of the Molecular Basis of Epigenetics
TL;DR: This chapter provides an overview of the emerging appreciation of roles for epigenetic molecular mechanisms in brain function in health and disease, highlighting recent breakthrough advances in the field that have occurred over the last decade.
Dissertation
Absence and mixed forms of epilepsy in WAG/RIJ RATS. Characteristics and brain aminergic modulations
TL;DR: It is hypothesized that the tone of the brain aminergic system in absence epileptic subjects is different from that of non-epileptic controls, which could lead to a poor ability of coping with stress and proposed that the seizure-related changes in neurochemistry of the limbic system might underlie an enhanced stress vulnerability of absence epilepsy patients and rats.
Journal ArticleDOI
Toward a complex system understanding of bipolar disorder: A chaotic model of abnormal circadian activity rhythms in euthymic bipolar disorder:
TL;DR: A novel mathematical model of a chaotic system which represents fluctuations in circadian activity in bipolar disorder as changes in the model’s parameters is developed, the first model to mathematically represent this multilevel explanation of the phenomena of bipolar disorder.
Journal ArticleDOI
The role of ARID1B, a BAF chromatin remodeling complex subunit, in neural development and behavior.
Jeffrey J. Moffat,Eui-Man Jung,Minhan Ka,Amanda L. Smith,Byeong Tak Jeon,Gijs W. E. Santen,Woo Yang Kim +6 more
TL;DR: The utility of the Arid1b heterozygous mouse model in neurodevelopmental and psychiatric research is discussed and some of the opportunities and potential challenges in developing translational applications for humans are discussed.
Journal ArticleDOI
Positive allosteric modulation of GABAB receptors ameliorates sensorimotor gating in rodent models
Roberto Frau,Valentina Bini,Giuliano Pillolla,Pari Malherbe,Alessandra Pardu,Andrew Thomas,Paola Devoto,Marco Bortolato,Marco Bortolato +8 more
TL;DR: This study analyzed whether rac‐BHFF, a potent GABABR‐positive allosteric modulator (PAM), could counter spontaneous and pharmacologically induced PPI deficits across various rodent models.
References
More filters
Journal ArticleDOI
Cholinergic innervation of cortex by the basal forebrain : cytochemistry and cortical connections of the septal area, diagonal band nuclei, nucleus basalis (substantia innominata), and hypothalamus in the rhesus monkey
TL;DR: The organization of projections from the cholinergic neurons of the basal forebrain to neocortex and associated structures was investigated in the rhesus monkey with the help of horseradish peroxidase transport, acetyl‐cholinesterase histochemistry, and choline acetyltransferase immunohis‐tochemistry.
Journal ArticleDOI
Synchronized oscillations in interneuron networks driven by metabotropic glutamate receptor activation
TL;DR: It is proposed that interneuron network oscillations, in conjunction with intrinsic membrane resonances and long-loop (such as thalamocortical) interactions, contribute to 40-Hz rhythms in vivo.
Journal ArticleDOI
Gamma (40-100 Hz) oscillation in the hippocampus of the behaving rat
TL;DR: It is suggested that gamma oscillation emerges from an interaction between intrinsic oscillatory properties of interneurons and the network properties of the dentate gyrus and that Gamma oscillation in the CA3-CA1 circuitry is suppressed by either the hilar region or the entorhinal cortex.
Journal ArticleDOI
Two networks of electrically coupled inhibitory neurons in neocortex
TL;DR: Two functionally distinct inhibitory networks comprising either fast-spiking (FS) or low-threshold spiking (LTS) neurons are described, which may allow each inhibitory network to function independently.