GABAergic Interneurons: Implications for Understanding Schizophrenia and Bipolar Disorder
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TLDR
Investigation of the GABA system in rodent, primate and human brain and the characterization of changes in specific phenotypic subclasses of interneurons in schizophrenia and bipolar disorder will undoubtedly provide important new insights into how the integration of this transmitter system may be altered in neuropsychiatric disease.About:
This article is published in Neuropsychopharmacology.The article was published on 2001-07-01 and is currently open access. It has received 1063 citations till now. The article focuses on the topics: GABAergic & Interneuron.read more
Citations
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Cortical inhibitory neurons and schizophrenia
TL;DR: Convergent findings indicate that a deficiency in signalling through the TrkB neurotrophin receptor leads to reduced GABA synthesis in the parvalbumin-containing subpopulation of inhibitory GABA neurons in the dorsolateral prefrontal cortex of individuals with schizophrenia.
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The principal features and mechanisms of dopamine modulation in the prefrontal cortex
TL;DR: Certain principles of DA mechanisms are identified by drawing on published, as well as unpublished data from PFC and other CNS sites to shed light on aspects of DA neuromodulation and address some of the existing controversies.
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Epigenetic Regulations of GABAergic Neurotransmission: Relevance for Neurological Disorders and Epigenetic Therapy
TL;DR: How various genetic and epigenetic events regulate the GABAergic genes in pre- and postnatal brain contribute to the pathogenesis of neurological disorders and can be used in the development of potential epigenetic therapy for these diseases.
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Interneuron dysfunction in psychiatric disorders
TL;DR: In conclusion, animal models demonstrate that the molecular basis of disruption is linked to specific defects in the development and function of interneurons — the cells that are responsible for establishing inhibitory circuits in the brain.
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The origin and specification of cortical interneurons
TL;DR: Recent data that are beginning to illuminate the origins and specification of distinct subgroups of cortical interneurons are discussed.
References
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Simulation of gamma rhythms in networks of interneurons and pyramidal cells.
TL;DR: The model suggests that pools of synaptically interconnected inhibitory cells are sufficient to produce gamma frequency rhythms, but the network behavior can be modified by participation of pyramidal cells.
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A reduction of nonpyramidal cells in sector CA2 of schizophrenics and manic depressives.
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D1 Receptor in Interneurons of Macaque Prefrontal Cortex: Distribution and Subcellular Localization
TL;DR: It is shown that D1-like immunoreactivity (D1-LIR) is also present in interneurons, raising the possibility that the circuit basis of working memory in the prefrontal cortex involves a D1 -mediated inhibitory component.
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Neurons in rat cerebral cortex that synthesize nitric oxide: NADPH diaphorase histochemistry, NOS immunocytochemistry, and colocalization with GABA
Juli G. Valtschanoff,Richard J. Weinberg,Viktor Kharazia,Harald H.H.W. Schmidt,Masaki Nakane,Aldo Rustioni +5 more
TL;DR: Neurons that stain for NADPH diaphorase, which colocalizes with nitric oxide synthase (NOS), are scattered uniformly across neocortex, and denser in entorhinal cortex, whereas NOS-positive fibers are concentrated in layers IV and VI.
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A microcolumnar structure of monkey cerebral cortex revealed by immunocytochemical studies of double bouquet cell axons.
TL;DR: The data suggest that the double bouquet cell is a chemically heterogeneous, but ubiquitous morphological type of cortical interneuron, whose uniquely bundled axonal system, which is probably GABAergic, imposes a fundamental microcolumnar organization upon the cerebral cortex.