GABAergic Interneurons: Implications for Understanding Schizophrenia and Bipolar Disorder
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TLDR
Investigation of the GABA system in rodent, primate and human brain and the characterization of changes in specific phenotypic subclasses of interneurons in schizophrenia and bipolar disorder will undoubtedly provide important new insights into how the integration of this transmitter system may be altered in neuropsychiatric disease.About:
This article is published in Neuropsychopharmacology.The article was published on 2001-07-01 and is currently open access. It has received 1063 citations till now. The article focuses on the topics: GABAergic & Interneuron.read more
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Journal ArticleDOI
Current Concepts and Treatments of Schizophrenia
TL;DR: Current hypotheses of schizophrenia, involving different neurotransmitter systems, discuss available treatments and present novel concepts in schizophrenia and its treatment, involving mainly novel mechanisms of GPCRs signaling are covered.
Journal ArticleDOI
Prefrontal activation deficits during episodic memory in schizophrenia
John D Ragland,Angela R. Laird,Charan Ranganath,Robert S. Blumenfeld,Sabina M. Gonzales,David C. Glahn +5 more
TL;DR: The finding of prominent prefrontal dysfunction suggests that cognitive control deficits strongly contribute to episodic memory impairment in schizophrenia, and memory rehabilitation approaches developed for patients with frontal lobe lesions and pharmacotherapy approaches designed to improve prefrontal cortex function hold special promise for remediating memory deficits in patients with schizophrenia.
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A pharmacological model for psychosis based on N-methyl-D-aspartate receptor hypofunction : Molecular, cellular, functional and behavioral abnormalities
Dan Rujescu,Andreas Bender,Martin E. Keck,Annette M. Hartmann,Frauke Ohl,Hanna Raeder,Ina Giegling,Just Genius,Robert W. McCarley,Hans-Jürgen Möller,Heinz Grunze +10 more
TL;DR: Animal models for psychosis based on a glutamatergic approach have a significant potential of serving as a model of the pathobiology of several aspects of psychosis and consequently could contribute to the development of new therapeutic strategies.
Journal ArticleDOI
Valproate corrects the schizophrenia-like epigenetic behavioral modifications induced by methionine in mice.
Lucio Tremolizzo,Mohemed Salim Doueiri,Erbo Dong,Dennis R. Grayson,John M. Davis,Graziano Pinna,Patricia Tueting,Virginia Rodriguez-Menendez,Erminio Costa,Alessandro Guidotti +9 more
TL;DR: This MET-induced epigenetic mouse models the neurochemical and behavioral aspects of SZ that can be corrected by positively modulating the action of GABA at alpha(5)-containing GABA(A) receptors with imidazenil or by inhibiting HDACs with valproate, thus opening exciting new avenues for treatment of epigenetically modified chromatin in SZ morbidity.
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Atypical antipsychotics attenuate a sub-chronic PCP-induced cognitive deficit in the novel object recognition task in the rat
TL;DR: Clozapine and risperidone but not haloperidol showed efficacy to reverse the deficit induced by sub-chronic PCP suggesting that this test may have some validity for assessing efficacy for improvement of cognitive deficit symptoms of schizophrenia.
References
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Journal ArticleDOI
Cholinergic innervation of cortex by the basal forebrain : cytochemistry and cortical connections of the septal area, diagonal band nuclei, nucleus basalis (substantia innominata), and hypothalamus in the rhesus monkey
TL;DR: The organization of projections from the cholinergic neurons of the basal forebrain to neocortex and associated structures was investigated in the rhesus monkey with the help of horseradish peroxidase transport, acetyl‐cholinesterase histochemistry, and choline acetyltransferase immunohis‐tochemistry.
Journal ArticleDOI
Synchronized oscillations in interneuron networks driven by metabotropic glutamate receptor activation
TL;DR: It is proposed that interneuron network oscillations, in conjunction with intrinsic membrane resonances and long-loop (such as thalamocortical) interactions, contribute to 40-Hz rhythms in vivo.
Journal ArticleDOI
Gamma (40-100 Hz) oscillation in the hippocampus of the behaving rat
TL;DR: It is suggested that gamma oscillation emerges from an interaction between intrinsic oscillatory properties of interneurons and the network properties of the dentate gyrus and that Gamma oscillation in the CA3-CA1 circuitry is suppressed by either the hilar region or the entorhinal cortex.
Journal ArticleDOI
Two networks of electrically coupled inhibitory neurons in neocortex
TL;DR: Two functionally distinct inhibitory networks comprising either fast-spiking (FS) or low-threshold spiking (LTS) neurons are described, which may allow each inhibitory network to function independently.