GABAergic Interneurons: Implications for Understanding Schizophrenia and Bipolar Disorder
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TLDR
Investigation of the GABA system in rodent, primate and human brain and the characterization of changes in specific phenotypic subclasses of interneurons in schizophrenia and bipolar disorder will undoubtedly provide important new insights into how the integration of this transmitter system may be altered in neuropsychiatric disease.About:
This article is published in Neuropsychopharmacology.The article was published on 2001-07-01 and is currently open access. It has received 1063 citations till now. The article focuses on the topics: GABAergic & Interneuron.read more
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Cortical inhibitory neurons and schizophrenia
TL;DR: Convergent findings indicate that a deficiency in signalling through the TrkB neurotrophin receptor leads to reduced GABA synthesis in the parvalbumin-containing subpopulation of inhibitory GABA neurons in the dorsolateral prefrontal cortex of individuals with schizophrenia.
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The principal features and mechanisms of dopamine modulation in the prefrontal cortex
TL;DR: Certain principles of DA mechanisms are identified by drawing on published, as well as unpublished data from PFC and other CNS sites to shed light on aspects of DA neuromodulation and address some of the existing controversies.
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Epigenetic Regulations of GABAergic Neurotransmission: Relevance for Neurological Disorders and Epigenetic Therapy
TL;DR: How various genetic and epigenetic events regulate the GABAergic genes in pre- and postnatal brain contribute to the pathogenesis of neurological disorders and can be used in the development of potential epigenetic therapy for these diseases.
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Interneuron dysfunction in psychiatric disorders
TL;DR: In conclusion, animal models demonstrate that the molecular basis of disruption is linked to specific defects in the development and function of interneurons — the cells that are responsible for establishing inhibitory circuits in the brain.
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The origin and specification of cortical interneurons
TL;DR: Recent data that are beginning to illuminate the origins and specification of distinct subgroups of cortical interneurons are discussed.
References
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Journal ArticleDOI
Coherent oscillations and short-term plasticity in corticothalamic networks.
TL;DR: The study of coherent oscillations, as they appear naturally during states of vigilance in animals and humans, requires intact-brain preparations in which the neocortex and thalamus engage in a permanent dialog.
Journal ArticleDOI
Laminar sources of synaptic input to cortical inhibitory interneurons and pyramidal neurons.
TL;DR: Differential laminar sources of excitatory inputs contribute to the functional diversity of cortical inhibitory interneurons.
Journal ArticleDOI
The axo-axonic interneuron in the cerebral cortex of the rat, cat and monkey.
TL;DR: It is concluded that the presence of axo-axonic cells in all the species and cortical areas examined suggests their association with the structural design of pyramidal cells, wherever the latter occur, and with their participation in the information processing of pyramsidal cells.
Journal ArticleDOI
Different populations of vasoactive intestinal polypeptide-immunoreactive interneurons are specialized to control pyramidal cells or interneurons in the hippocampus
TL;DR: A new element in cortical microcircuits, interneurons which are specialized to innervate other GABAergic interneuron types are revealed, which is likely to be involved in perisomatic inhibition of pyramidal neurons, and represents a new basket cell type different from that containing parvalbumin.
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Smaller neuron size in schizophrenia in hippocampal subfields that mediate cortical-hippocampal interactions.
Steven E. Arnold,Bryan R. Franz,Ruben C. Gur,Raquel E. Gur,Raymond M. Shapiro,Paul J. Moberg,John Q. Trojanowski +6 more
TL;DR: The subiculum, entorhinal cortex, and CA1 are the major subfields of the hippocampal region that maintain the afferent and efferent connections of the hippocampus with widespread cortical and subcortical targets.