GABAergic Interneurons: Implications for Understanding Schizophrenia and Bipolar Disorder
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TLDR
Investigation of the GABA system in rodent, primate and human brain and the characterization of changes in specific phenotypic subclasses of interneurons in schizophrenia and bipolar disorder will undoubtedly provide important new insights into how the integration of this transmitter system may be altered in neuropsychiatric disease.About:
This article is published in Neuropsychopharmacology.The article was published on 2001-07-01 and is currently open access. It has received 1063 citations till now. The article focuses on the topics: GABAergic & Interneuron.read more
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Epigenetic regulation on GABRB2 isoforms expression: developmental variations and disruptions in psychotic disorders.
Cunyou Zhao,Feng Wang,Frank Wing Pun,Lingling Mei,Lihuan Ren,Zhiliang Yu,Sin Kin Ng,Jianhuan Chen,Shui Ying Tsang,Hong Xue +9 more
TL;DR: These findings demonstrated that GABRB2 expression was under epigenetic regulation that varied with development, genotype and disease status, and these regulatory mechanisms were observably disrupted in SCZ and BPD.
Journal ArticleDOI
GABRB2 in schizophrenia and bipolar disorder: disease association, gene expression and clinical correlations
J.-H. Chen,Shui Ying Tsang,Cunyou Zhao,F.W. Pun,Z.-L. Yu,L.-L. Mei,W.-S. Lo,S.-K. Ng,H. Liu,Gerald Stöber,Hong Xue +10 more
TL;DR: The findings highlight the importance of GABRB2 in neuropsychiatric disease aetiology, with respect to haplotype association, as well as reduction of and temporal effects on gene expression in both SCZ and BPD, but to a lesser extent in the latter, supporting the suggestion that functional psychosis can be conceptualized as a continuous spectrum of clinical phenotypes rather than as distinct categories.
Journal ArticleDOI
Comparison of neurocognition between drug-free patients with schizophrenia and bipolar disorder.
Wai-Cheong Carl Tam,Zhening Liu +1 more
TL;DR: Neurocognitive tasks had better discriminative power for medicated patients with schizophrenia and bipolar disorder than for drug-free patients, and medication effects did not seem to significantly change the pattern of the neurocognitive task responses of patients with psychosis.
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Post-weaning social isolation rearing influences the expression of molecules related to inhibitory neurotransmission and structural plasticity in the amygdala of adult rats.
TL;DR: The results indicate that isolation-rearing influences positively inhibitory neurotransmission and neuronal structural plasticity in the amygdala, probably through PSA-NCAM.
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Schizophrenia: a unique translational opportunity in behavioral neuroendocrinology.
TL;DR: Data on the importance of gestational stress exposure to the etiology of schizophrenia-like behavioral, endocrine and molecular phenotypes will be presented and differences will be highlighted between the preparations that are commonly used in most laboratory investigations.
References
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Gamma (40-100 Hz) oscillation in the hippocampus of the behaving rat
TL;DR: It is suggested that gamma oscillation emerges from an interaction between intrinsic oscillatory properties of interneurons and the network properties of the dentate gyrus and that Gamma oscillation in the CA3-CA1 circuitry is suppressed by either the hilar region or the entorhinal cortex.
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Two networks of electrically coupled inhibitory neurons in neocortex
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