GABAergic Interneurons: Implications for Understanding Schizophrenia and Bipolar Disorder
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TLDR
Investigation of the GABA system in rodent, primate and human brain and the characterization of changes in specific phenotypic subclasses of interneurons in schizophrenia and bipolar disorder will undoubtedly provide important new insights into how the integration of this transmitter system may be altered in neuropsychiatric disease.About:
This article is published in Neuropsychopharmacology.The article was published on 2001-07-01 and is currently open access. It has received 1063 citations till now. The article focuses on the topics: GABAergic & Interneuron.read more
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BL-1020: a novel antipsychotic drug with GABAergic activity and low catalepsy, is efficacious in a rat model of schizophrenia.
Yona Geffen,Abraham Nudelman,Irit Gil-Ad,Ada Rephaeli,Mei Huang,Kinneret Savitsky,Leah N. Klapper,Ilan Winkler,Herbert Y. Meltzer,Abraham Weizman +9 more
TL;DR: The advantages of BL-1020 for treatment of schizophrenia stem from its being a DA/5HT antagonist and a GABAergic agonist that releases cortical DA and antagonizes amphetamine-induced hyperactivity with reduced catalepsy and sedation.
Journal ArticleDOI
Auditory inhibitory gating in the amygdala: Single-unit analysis in the behaving rat
TL;DR: The existence of inhibitory gating in the amygdala is demonstrated and a detailed description of the basic properties of this rapid neural inhibition that could play an important role in filtering stimulus input is provided.
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Auditory steady state response deficits are associated with symptom severity and poor functioning in patients with psychotic disorder.
Tian-Hang Zhou,Nora E. Mueller,Kevin M. Spencer,Sonal G. Mallya,Kathryn E. Lewandowski,Lesley A. Norris,Deborah L. Levy,Bruce M. Cohen,Dost Öngür,Mei-Hua Hall +9 more
TL;DR: Severity of hallucinatory symptom and community functioning, particularly independent living/meaningful activity, were significantly and independently associated with the 40 Hz ASSR.
Journal ArticleDOI
Translational and developmental perspective on N-methyl-D-aspartate synaptic deficits in schizophrenia
TL;DR: The data attributing the disorganization symptoms of schizophrenia to a failure of executive, prefrontal cortical processes are summarized, and the hypothesis that this failure reflects an impairment in N-methyl-D-aspartate (NMDA) glutamatergic neurotransmission is described, that is likely to involve both the dysregulated function of NMDA synapses, as well as the physical loss of NMda synapses.
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Striatal Transcriptome and Interactome Analysis of Shank3-overexpressing Mice Reveals the Connectivity between Shank3 and mTORC1 Signaling
Yeunkum Lee,Sun-Gyun Kim,Bokyoung Lee,Yinhua Zhang,Yoonhee Kim,Shinhyun Kim,Eunjoon Kim,Hyojin Kang,Kihoon Han +8 more
TL;DR: A protein interaction-mediated connectivity between Shank3 and certain upstream regulators of m TORC1 that might contribute to the abnormal striatal mTORC1 activity and to the manic-like behaviors of Shank3 TG mice is suggested.
References
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