GABAergic Interneurons: Implications for Understanding Schizophrenia and Bipolar Disorder
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Investigation of the GABA system in rodent, primate and human brain and the characterization of changes in specific phenotypic subclasses of interneurons in schizophrenia and bipolar disorder will undoubtedly provide important new insights into how the integration of this transmitter system may be altered in neuropsychiatric disease.About:
This article is published in Neuropsychopharmacology.The article was published on 2001-07-01 and is currently open access. It has received 1063 citations till now. The article focuses on the topics: GABAergic & Interneuron.read more
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Journal ArticleDOI
[Origin of cortical interneurons: basic concepts and clinical implications]
TL;DR: This review has summarized the current knowledge of the factors that control the specification of cortical interneurons, as well as the mechanisms that direct their migration to the cortex.
DissertationDOI
The role of redox dysregulation in the effects of prenatal stress on the embryonic and adult mouse brain
Alternations of NMDA and GABAB Receptor Function in Development: A Potential Animal Model of Schizophrenia
TL;DR: The purpose of the below studies was to determine if changes in NMDA receptor function or alterations in downstream GABA receptor function during development in rodent pups results in behavioral or biochemical alterations in adulthood that are relevant to schizophrenia.
Book ChapterDOI
Gestational MAM (Methylazoxymethanol) Administration: A Promising Animal Model for Psychosis Onset
TL;DR: The E17 MAM model that incorporates neuropathological and functional manifestations associated with schizophrenia may help forward early preventive interventions that can successfully reduce the risk of developing schizophrenia in exposed individuals.
Book ChapterDOI
Stress Sensitization and Anticonvulsant Medication in Psychiatric Patients
TL;DR: Findings strongly suggest that stress-activated limbic kindling may be involved in the pathogenesis of depression, posttraumatic stress disorder (PTSD), schizophrenia and other psychiatric disorders which may explain efficacy of antiepileptic drugs in their treatment.
References
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Cholinergic innervation of cortex by the basal forebrain : cytochemistry and cortical connections of the septal area, diagonal band nuclei, nucleus basalis (substantia innominata), and hypothalamus in the rhesus monkey
TL;DR: The organization of projections from the cholinergic neurons of the basal forebrain to neocortex and associated structures was investigated in the rhesus monkey with the help of horseradish peroxidase transport, acetyl‐cholinesterase histochemistry, and choline acetyltransferase immunohis‐tochemistry.
Journal ArticleDOI
Synchronized oscillations in interneuron networks driven by metabotropic glutamate receptor activation
TL;DR: It is proposed that interneuron network oscillations, in conjunction with intrinsic membrane resonances and long-loop (such as thalamocortical) interactions, contribute to 40-Hz rhythms in vivo.
Journal ArticleDOI
Gamma (40-100 Hz) oscillation in the hippocampus of the behaving rat
TL;DR: It is suggested that gamma oscillation emerges from an interaction between intrinsic oscillatory properties of interneurons and the network properties of the dentate gyrus and that Gamma oscillation in the CA3-CA1 circuitry is suppressed by either the hilar region or the entorhinal cortex.
Journal ArticleDOI
Two networks of electrically coupled inhibitory neurons in neocortex
TL;DR: Two functionally distinct inhibitory networks comprising either fast-spiking (FS) or low-threshold spiking (LTS) neurons are described, which may allow each inhibitory network to function independently.