Genomic control for association studies.
Bernie Devlin,Kathryn Roeder +1 more
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The performance of the genomic control method is quite good for plausible effects of liability genes, which bodes well for future genetic analyses of complex disorders.Abstract:
A dense set of single nucleotide polymorphisms (SNP) covering the genome and an efficient method to assess SNP genotypes are expected to be available in the near future. An outstanding question is how to use these technologies efficiently to identify genes affecting liability to complex disorders. To achieve this goal, we propose a statistical method that has several optimal properties: It can be used with case control data and yet, like family-based designs, controls for population heterogeneity; it is insensitive to the usual violations of model assumptions, such as cases failing to be strictly independent; and, by using Bayesian outlier methods, it circumvents the need for Bonferroni correction for multiple tests, leading to better performance in many settings while still constraining risk for false positives. The performance of our genomic control method is quite good for plausible effects of liability genes, which bodes well for future genetic analyses of complex disorders.read more
Citations
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Multifactor dimensionality reduction for detecting gene-gene and gene-environment interactions in pharmacogenomics studies.
TL;DR: MDR is a nonparametric and model-free approach that has been shown to have reasonable power to detect epistasis in both theoretical and empirical studies and its application in pharmacogenomic studies is demonstrated.
Journal ArticleDOI
Eight common genetic variants associated with serum DHEAS levels suggest a key role in ageing mechanisms
Guangju Zhai,Alexander Teumer,Lisette Stolk,John R. B. Perry,John R. B. Perry,Liesbeth Vandenput,Andrea D. Coviello,Annemarie Koster,Jordana T. Bell,Jordana T. Bell,Shalender Bhasin,Joel Eriksson,Anna Eriksson,Florian Ernst,Luigi Ferrucci,Timothy M. Frayling,Daniel Glass,Elin Grundberg,Elin Grundberg,Robin Haring,Åsa K. Hedman,Albert Hofman,Douglas P. Kiel,Heyo K. Kroemer,Yongmei Liu,Kathryn L. Lunetta,Marcello Maggio,Mattias Lorentzon,Massimo Mangino,David Melzer,Iva Miljkovic,Alexandra C. Nica,Alexandra C. Nica,Brenda W.J.H. Penninx,Ramachandran S. Vasan,Ramachandran S. Vasan,Fernando Rivadeneira,Kerrin S. Small,Kerrin S. Small,Nicole Soranzo,Nicole Soranzo,André G. Uitterlinden,Henry Völzke,Scott Wilson,Scott Wilson,Scott Wilson,Li Xi,Wei Vivian Zhuang,Tamara B. Harris,Joanne M. Murabito,Joanne M. Murabito,Claes Ohlsson,Anna Murray,Frank H. de Jong,Tim D. Spector,Henri Wallaschofski +55 more
TL;DR: A meta-analysis of genome-wide association data with 14,846 individuals found several SNPs were associated with changes in gene expression levels, and the related genes are connected to biological pathways linking DHEAS with ageing.
Journal ArticleDOI
Genetic association analysis highlights new loci that modulate hematological trait variation in Caucasians and African Americans
Ken Sin Lo,James G. Wilson,Leslie A. Lange,Aaron R. Folsom,Geneviève Galarneau,Santhi K. Ganesh,Struan F.A. Grant,Brendan J. Keating,Steven A. McCarroll,Steven A. McCarroll,Emile R. Mohler,Christopher J. O'Donnell,Christopher J. O'Donnell,Walter Palmas,Weihong Tang,Russell P. Tracy,Alexander P. Reiner,Guillaume Lettre +17 more
TL;DR: The results show similarities but also differences in the genetic regulation of hematological traits in European- and African-derived populations, and highlight the role of natural selection in shaping these differences.
Journal ArticleDOI
Genetics of COPD.
TL;DR: Every genetic study on COPD has some limitations including heterogeneity in smoking behaviors and comorbidities, it has contributed to the progress in elucidating the pathogenesis of COPD, leading to the development of a specific treatment for each phenotype.
Journal ArticleDOI
Genome-wide association study identifies loci on 12q24 and 13q32 associated with Tetralogy of Fallot
Heather J. Cordell,Ana Töpf,Chrysovalanto Mamasoula,Alex V. Postma,Jamie Bentham,Diana Zelenika,Simon Heath,Gillian M. Blue,Catherine Cosgrove,Javier Granados Riveron,Rebecca Darlay,Rachel Soemedi,Ian J. Wilson,Kristin L. Ayers,Thahira Rahman,Darroch Hall,Barbara J.M. Mulder,A. H. Zwinderman,Klaartje van Engelen,J. David Brook,Kerry Setchfield,Frances A. Bu'Lock,Chris Thornborough,John O'Sullivan,A Graham Stuart,Jonathan M. Parsons,Shoumo Bhattacharya,David S. Winlaw,Seema Mital,Marc Gewillig,Jeroen Breckpot,Koenraad Devriendt,Antoon F.M. Moorman,Anita Rauch,G. Mark Lathrop,Bernard Keavney,Judith A. Goodship +36 more
TL;DR: This study, the first genome-wide association study of a congenital heart malformation phenotype, provides evidence that common genetic variation influences the risk of TOF.
References
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Stastical Decision Theory and Bayesian Analysis.
Malay Ghosh,James O. Berger +1 more
Book
Statistical Decision Theory and Bayesian Analysis
TL;DR: An overview of statistical decision theory, which emphasizes the use and application of the philosophical ideas and mathematical structure of decision theory.
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The Future of Genetic Studies of Complex Human Diseases
TL;DR: The identification of the genetic basis of complex human diseases such as schizophrenia and diabetes has proven difficult as mentioned in this paper, and Risch and Merikangas proposed that they can best accomplish this goal by combining the power of the human genome project with association studies.
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An Introduction to Population Genetics Theory
James F. Crow,Motoo Kimura +1 more
TL;DR: An introduction to population genetics theory, An introduction to Population Genetics Theory, Population Genetics theory, Population genetics theory as discussed by the authors, Population genetics, population genetics, and population genetics theories, Population Genetic Theory
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An introduction to population genetics theory
James F. Crow,Motoo Kimura +1 more
TL;DR: An introduction to population genetics theory, An introduction to Population Genetics theory, and more.
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