Journal ArticleDOI
Genotoxicity of pyrroloquinoline quinone (PQQ) disodium salt (BioPQQ
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TLDR
PQQ disodium was concluded to have no genotoxic activity in vivo and the weak responses in the in vitro test CHL cells were considered of little relevance under conditions of likely human exposure.About:
This article is published in Regulatory Toxicology and Pharmacology.The article was published on 2013-11-01. It has received 20 citations till now. The article focuses on the topics: Micronucleus test & Genotoxicity.read more
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Journal ArticleDOI
Recent progress in studies on the health benefits of pyrroloquinoline quinone.
TL;DR: The potential health benefits of pyrroloquinoline quinone are reviewed with a focus on its growth-promoting activity, anti-diabetic effect,Anti-oxidative action, and neuroprotective function.
Journal ArticleDOI
Early PQQ supplementation has persistent long-term protective effects on developmental programming of hepatic lipotoxicity and inflammation in obese mice
Karen R. Jonscher,Michael S. Stewart,Alba Alfonso-Garcia,Brian C. DeFelice,Xiaoxin X. Wang,Yuhuan Luo,Moshe Levi,Margaret J. R. Heerwagen,Rachel C. Janssen,Becky A. de la Houssaye,Ellen Wiitala,Garrett Florey,Raleigh Jonscher,Eric O. Potma,Oliver Fiehn,Oliver Fiehn,Jacob E. Friedman +16 more
TL;DR: It is suggested that supplementation with PQQ, particularly during pregnancy and lactation, protects offspring from WD‐induced developmental programming of hepatic lipotoxicity and may help slow the advancing epidemic of NAFLD in the next generation.
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Protective Effect of Pyrroloquinoline Quinone (PQQ) in Rat Model of Intracerebral Hemorrhage.
TL;DR: The results showed that rats pretreated with PQQ at 10 mg/kg effectively improved the locomotor functions, alleviated the hematoma volumes, and reduced the expansion of brain edema after ICH, and speculated that PQZ might be an effective and potential neuroprotectant in clinical therapy for ICH.
Journal ArticleDOI
Pyrroloquinoline-Quinone Is More Than an Antioxidant: A Vitamin-like Accessory Factor Important in Health and Disease Prevention.
TL;DR: Pyrroloquinoline quinone (PQQ) is associated with biological processes such as mitochondriogenesis, reproduction, growth, and aging, and attenuates clinically relevant dysfunctions (e.g., those associated with ischemia, inflammation and lipotoxicity) as discussed by the authors.
Journal ArticleDOI
Acute and subchronic toxicity studies of pyrroloquinoline quinone (PQQ) disodium salt (BioPQQ™) in rats.
Masahiko Nakano,Hisaaki Takahashi,Seiko Koura,Catherine Chung,Shahrzad Tafazoli,Ashley Roberts +5 more
TL;DR: A no-observed-adverse-effect level of 100mg/kgbw/day was determined for BioPQQ™ in rats, the highest dose tested in the 13-week study, which was deemed to be of no toxicological significance.
References
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Journal ArticleDOI
Revised methods for the salmonella mutagenicity test
Dorothy M. Maron,Bruce N. Ames +1 more
TL;DR: Two new tester strains, a frameshift strain and a strain carrying an ochre mutation on a multicopy plasmid (TA102), are added to the standard tester set and two substitutions are made in diagnostic mutagens to eliminate MNNG and 9-aminoacridine.
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How to reduce false positive results when undertaking in vitro genotoxicity testing and thus avoid unnecessary follow-up animal tests: Report of an ECVAM Workshop.
David Kirkland,Stefan Pfuhler,David Tweats,Marilyn J. Aardema,Raffaella Corvi,Firouz Darroudi,Azeddine Elhajouji,Hansruedi Glatt,Paul W. Hastwell,M. Hayashi,Peter Kasper,Stephan Kirchner,Anthony M. Lynch,Daniel Marzin,Daniela Maurici,Jean-Roc Meunier,Lutz Müller,Gerhard J. Nohynek,James M. Parry,Elizabeth M. Parry,Véronique Thybaud,Ray Tice,Jan van Benthem,Philippe Vanparys,Paul D. White +24 more
TL;DR: It was concluded that better guidance on the likely mechanisms resulting in positive results that are not biologically relevant for human health, and how to obtain evidence for those mechanisms, is needed both for practitioners and regulatory reviewers.
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A novel coenzyme from bacterial primary alcohol dehydrogenases
TL;DR: The primary alcohol dehydrogenases from a variety of methanol-grown bacteria have been purified and compared, and seem to contain a common and novel cofactor which may be more generally associated with the oxidation of single-carbon compounds.
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Mutagenicity of quinones: pathways of metabolic activation and detoxification
TL;DR: The complexity of metabolic pathways involved in the mutagenicity of quinones, a class of compounds widely distributed in nature, are shown, including a cytochrome P-450-dependent reaction, whereas danthron was converted to a highly mutagenic metabolite.
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Reduction of misleading ("false") positive results in mammalian cell genotoxicity assays. I. Choice of cell type.
Paul Fowler,Katie Smith,Jamie Young,Laura Jeffrey,David Kirkland,Stefan Pfuhler,Paul L. Carmichael +6 more
TL;DR: Compared rodent cell lines with p53-competent human peripheral blood lymphocytes, TK6 human lymphoblastoid cells, and the human liver cell line, HepG2, suggest that a reduction in the frequency of misleading positive results can be achieved by careful selection of the mammalian cell type for genotoxicity testing.