Dietary pyrroloquinoline quinone (PQQ) alters indicators of inflammation and mitochondrial-related metabolism in human subjects.
Calliandra Harris,Winyoo Chowanadisai,Darya O. Mishchuk,Mike A. Satre,Carolyn M. Slupsky,Robert B. Rucker +5 more
TLDR
Dietary PQQ exposure resulted in significant decreases in the levels of plasma C-reactive protein, IL-6 and urinary methylated amines such as trimethylamine N-oxide, and changes in urinary metabolites consistent with enhanced mitochondria-related functions, among the first to link systemic effects of P QQ in animals to corresponding effects in humans.Abstract:
Pyrroloquinoline quinone (PQQ) influences energy-related metabolism and neurologic functions in animals. The mechanism of action involves interactions with cell signaling pathways and mitochondrial function. However, little is known about the response to PQQ in humans. Using a crossover study design, 10 subjects (5 females, 5 males) ingested PQQ added to a fruit-flavored drink in two separate studies. In study 1, PQQ was given in a single dose (0.2 mg PQQ/kg). Multiple measurements of plasma and urine PQQ levels and changes in antioxidant potential [based on total peroxyl radical-trapping potential and thiobarbituric acid reactive product (TBAR) assays] were made throughout the period of 48 h. In study 2, PQQ was administered as a daily dose (0.3 mg PQQ/kg). After 76 h, measurements included indices of inflammation [plasma C-reactive protein, interleukin (IL)-6 levels], standard clinical indices (e.g., cholesterol, glucose, high-density lipoprotein, low-density lipoprotein, triglycerides, etc.) and (1)H-nuclear magnetic resonance estimates of urinary metabolites related in part to oxidative metabolism. The standard clinical indices were normal and not altered by PQQ supplementation. However, dietary PQQ exposure (Study 1) resulted in apparent changes in antioxidant potential based on malonaldehyde-related TBAR assessments. In Study 2, PQQ supplementation resulted in significant decreases in the levels of plasma C-reactive protein, IL-6 and urinary methylated amines such as trimethylamine N-oxide, and changes in urinary metabolites consistent with enhanced mitochondria-related functions. The data are among the first to link systemic effects of PQQ in animals to corresponding effects in humans.read more
Citations
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Prolonging healthy aging: Longevity vitamins and proteins
TL;DR: It is proposed that nutrients required for the function of longevity proteins constitute a class of vitamins that are here named “longevity vitamins” and it is suggested that many such nutrients play a dual role for both survival and longevity.
Journal ArticleDOI
Recent progress in studies on the health benefits of pyrroloquinoline quinone.
TL;DR: The potential health benefits of pyrroloquinoline quinone are reviewed with a focus on its growth-promoting activity, anti-diabetic effect,Anti-oxidative action, and neuroprotective function.
Journal ArticleDOI
Discovery of a eukaryotic pyrroloquinoline quinone-dependent oxidoreductase belonging to a new auxiliary activity family in the database of carbohydrate-active enzymes.
Hirotoshi Matsumura,Kiwamu Umezawa,Kouta Takeda,Naohisa Sugimoto,Takuya Ishida,Masahiro Samejima,Hiroyuki Ohno,Makoto Yoshida,Kiyohiko Igarashi,Nobuhumi Nakamura +9 more
TL;DR: BLAST search uncovered the existence of many genes encoding homologous proteins in bacteria, archaea, amoebozoa, and fungi, and phylogenetic analysis suggested that these quinoproteins may be members of a new family that is widely distributed not only in prokaryotes, but also in eukaryotes.
Journal ArticleDOI
Catalysis of Heterocyclic Azadiene Cycloaddition Reactions by Solvent Hydrogen Bonding: Concise Total Synthesis of Methoxatin
TL;DR: Hydrogen bonding of non-nucleophilic perfluoroalcohols, including hexafluoroisopropanol and trifluoroethanol, is used to activate the electron-deficient heterocyclic azadienes in cycloaddition of 1,2,3-triazine 4 with enamine 3 as the key step of a concise total synthesis of methoxatin.
Journal ArticleDOI
Early PQQ supplementation has persistent long-term protective effects on developmental programming of hepatic lipotoxicity and inflammation in obese mice
Karen R. Jonscher,Michael S. Stewart,Alba Alfonso-Garcia,Brian C. DeFelice,Xiaoxin X. Wang,Yuhuan Luo,Moshe Levi,Margaret J. R. Heerwagen,Rachel C. Janssen,Becky A. de la Houssaye,Ellen Wiitala,Garrett Florey,Raleigh Jonscher,Eric O. Potma,Oliver Fiehn,Oliver Fiehn,Jacob E. Friedman +16 more
TL;DR: It is suggested that supplementation with PQQ, particularly during pregnancy and lactation, protects offspring from WD‐induced developmental programming of hepatic lipotoxicity and may help slow the advancing epidemic of NAFLD in the next generation.
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