Genotypic variation in the SV2C gene impacts response to atypical antipsychotics the CATIE Study
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TLDR
An association study for 106 SNPs in the synaptic vesicle protein 2C (SV2C) gene using genetic and treatment response data from the Clinical Trial of Antipsychotic Intervention Effectiveness (CATIE) suggests that further evaluation ofSNPs in this gene as PGx predictors of antipsychotic response is warranted.About:
This article is published in Schizophrenia Research.The article was published on 2013-09-01 and is currently open access. It has received 24 citations till now. The article focuses on the topics: Quetiapine & Olanzapine.read more
Citations
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Journal ArticleDOI
Second-Generation Antipsychotics and Dysregulation of Glucose Metabolism: Beyond Weight Gain.
TL;DR: An outlook on current research about the metabolic disturbances provoked by SGAs is given, with a particular focus on whole-body glucose homeostasis disturbances induced independently of AIWG, lipid dysregulation or adipose tissue disturbances.
Journal ArticleDOI
Investigating the Lived Experience of Recovery in People Who Hear Voices
Adèle de Jager,Paul Rhodes,Vanessa Beavan,Douglas Holmes,Kathryn McCabe,Neil Thomas,Simon McCarthy-Jones,Debra Lampshire,Mark Hayward +8 more
TL;DR: Narrative inquiry was used to investigate voice-hearers’ lived experience of recovery, and results indicated the importance of services being sensitive and responsive to a person’s recovery style at any given time and their readiness for change.
Journal ArticleDOI
The Synaptic Vesicle Glycoprotein 2: Structure, Function, and Disease Relevance.
TL;DR: The structure and function of SV2 proteins are reviewed as well as their relevance to disease and therapeutic development, and several recent developments have enhanced understanding and appreciation of the protein family.
Journal ArticleDOI
Genetic variant predicts bevacizumab-induced hypertension in ECOG-5103 and ECOG-2100
Bryan P. Schneider,Lang Li,Fei Shen,Kathy D. Miller,Milan Radovich,A O'Neill,Robert Gray,D. Lane,David A. Flockhart,Guanglong Jiang,Z. Wang,Dongbing Lai,Daniel L. Koller,J. H. Pratt,Chau T. Dang,Donald W. Northfelt,Edith A. Perez,Tamara Shenkier,Melody A. Cobleigh,Mary Lou Smith,Elda Railey,Ann H. Partridge,Julie R. Gralow,Joseph A. Sparano,Nancy E. Davidson,Tatiana Foroud,George W. Sledge +26 more
TL;DR: In this article, a genome-wide association study (GWAS) was performed in the phase III bevacizumab-based adjuvant breast cancer trial, ECOG-5103, to evaluate for an association between genotypes and hypertension.
Genetic variant predicts bevacizumab-induced hypertension in ECOG-5103 and ECOG-2100
Bryan P. Schneider,Lang Li,Fei Shen,Kathy D. Miller,Milan Radovich,A O'Neill,Robert Gray,D. Lane,David A. Flockhart,Guanglong Jiang,Z. Wang,Dongbing Lai,Daniel L. Koller,J. H. Pratt,Chau T. Dang,Donald W. Northfelt,Edith A. Perez,Tamara Shenkier,Melody A. Cobleigh,Mary Lou Smith,Elda Railey,Ann H. Partridge,Julie R. Gralow,Joseph A. Sparano,Nancy E. Davidson,Tatiana Foroud,George W. Sledge +26 more
TL;DR: A genetic variant in SV2C predicted clinically relevant bevacizumab-induced hypertension in two independent, randomised phase III trials.
References
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Journal ArticleDOI
Haploview: analysis and visualization of LD and haplotype maps
TL;DR: Haploview is a software package that provides computation of linkage disequilibrium statistics and population haplotype patterns from primary genotype data in a visually appealing and interactive interface.
Journal ArticleDOI
Effectiveness of Antipsychotic Drugs in Patients with Chronic Schizophrenia
Jeffrey A. Lieberman,T. Scott Stroup,Joseph P. McEvoy,Joseph P. McEvoy,Marvin S. Swartz,Robert A. Rosenheck,Diana O. Perkins,Richard S.E. Keefe,Sonia M. Davis,C.E. Davis,Barry D. Lebowitz,Joanne B. Severe,John K. Hsiao +12 more
TL;DR: Olanzapine was the most effective in terms of the rates of discontinuation, and the efficacy of the conventional antipsychotic agent perphenazine appeared similar to that of quetiapine, risperidone, and ziprasidone.
Journal ArticleDOI
Controlling the false discovery rate in behavior genetics research
TL;DR: The False Discovery Rate (FDR) is the expected proportion of false discoveries among the discoveries, and controlling the FDR goes a long way towards controlling the increased error from multiplicity while losing less in the ability to discover real differences.
Journal ArticleDOI
The National Institute of Mental Health Clinical Antipsychotic Trials of Intervention Effectiveness (CATIE) Project: Schizophrenia Trial Design and Protocol Development
T. Scott Stroup,Joseph P. McEvoy,Marvin S. Swartz,Matthew J. Byerly,Ira D. Glick,José M. Cañive,Mark McGee,George M. Simpson,Michael C. Stevens,Jeffrey A. Lieberman +9 more
TL;DR: The CATIE schizophrenia trial blends features of efficacy studies and large, simple trials to create a pragmatic trial that will provide extensive information about antipsychotic drug effectiveness over at least 18 months.
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