Gestational age at initiation of 17-alpha hydroxyprogesterone caproate and recurrent preterm birth.
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The relationship between the gestational age at 17‐alpha hydroxyprogesterone caproate initiation and recurrent preterm birth among women with a prior spontaneous pre term birth 16–28 weeks’ gestation was examined.About:
This article is published in American Journal of Obstetrics and Gynecology.The article was published on 2017-09-01 and is currently open access. It has received 21 citations till now. The article focuses on the topics: Hydroxyprogesterone caproate & Premature birth.read more
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Inhibition of the NLRP3 inflammasome can prevent sterile intra-amniotic inflammation, preterm labor/birth, and adverse neonatal outcomes†.
Nardhy Gomez-Lopez,Nardhy Gomez-Lopez,Roberto Romero,Valeria Garcia-Flores,Valeria Garcia-Flores,Yaozhu Leng,Yaozhu Leng,Derek Miller,Derek Miller,Sonia S. Hassan,Sonia S. Hassan,Chaur-Dong Hsu,Bogdan Panaitescu,Bogdan Panaitescu +13 more
TL;DR: Evidence is provided that the alarmin S100B can induce sterile intra-amniotic inflammation, preterm labor/birth, and adverse neonatal outcomes by activating the NLRP3 inflammasome, which can be prevented by inhibiting such a pathway.
Journal ArticleDOI
Cervical pessary to prevent preterm birth in asymptomatic high-risk women: a systematic review and meta-analysis.
TL;DR: Current evidence does not support the use of cervical pessary to prevent preterm birth or improve perinatal outcomes in singleton or twin gestations with a short cervix and in unselected twingestations.
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Prediction and Prevention of Spontaneous Preterm Birth: ACOG Practice Bulletin, Number 234.
Journal ArticleDOI
The value of oral micronized progesterone in the prevention of recurrent spontaneous preterm birth: a randomized controlled trial
TL;DR: The role of oral micronized progesterone in preventing recurrent spontaneous preterm delivery and the effective types and doses to be used have not yet been thoroughly investigated.
Journal ArticleDOI
In an in-vitro model using human fetal membranes, 17-α hydroxyprogesterone caproate is not an optimal progestogen for inhibition of fetal membrane weakening.
Deepak Kumar,Robert M. Moore,Brian M. Mercer,Joseph M. Mansour,Sam Mesiano,Frederick Schatz,Charles J. Lockwood,John J. Moore +7 more
TL;DR: The inhibitory effects of 17‐OHPC on TNF‐&agr;– and thrombin‐induced fetal membrane weakening in vitro were characterized and it is speculated that progestogens other than 17‐alpha hydroxyprogesterone caproate may be more efficacious in preventing preterm premature rupture of the fetal membranes–related spontaneous preterm birth.
References
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Prevention of recurrent preterm delivery by 17 alpha-hydroxyprogesterone caproate.
Paul J. Meis,Mark A. Klebanoff,Elizabeth Thom,Mitchell P. Dombrowski,Baha M. Sibai,Atef H. Moawad,Catherine Y. Spong,John C. Hauth,Menachem Miodovnik,Menachem Miodovnik,Michael W. Varner,Kenneth J. Leveno,Steve N. Caritis,Jay D. Iams,Ronald J. Wapner,Deborah L. Conway,Mary Jo O'Sullivan,Marshall W. Carpenter,Brian M. Mercer,Susan M. Ramin,John M. Thorp,Alan M. Peaceman +21 more
TL;DR: In this paper, a double-blind, placebo-controlled trial involving pregnant women with a documented history of spontaneous preterm delivery was conducted, where women were enrolled at 19 clinical centers at 16 to 20 weeks of gestation.
Births: final data for 2013.
TL;DR: Birth rates declined for women in their 20s and increased for most age groups of women aged 30 and over in 2013, and measures of unmarried childbearing were down in 2013 from 2012.
Births: Final Data for 2015.
TL;DR: This report presents 2015 data on U.S. births according to a wide variety of characteristics, including maternal age, live-birth order, race and Hispanic origin, marital status, attendant at birth, method of delivery, period of gestation, birthweight, and plurality.
Journal ArticleDOI
Metronidazole to prevent preterm delivery in pregnant women with asymptomatic bacterial vaginosis
J. Christopher Carey,Mark A. Klebanoff,John C. Hauth,Sharon L. Hillier,Elizabeth Thom,J.M. Ernest,R. Phillip Heine,Robert P. Nugent,Molly L. Fischer,Kenneth J. Leveno,Ronald J. Wapner,Michael W. Varner,Wayne Trout,Atef H. Moawad,Bahaeddine M Sibai,Menachem Miodovnik,Mitchell P. Dombrowski,Mary Jo O'Sullivan,J. Peter VanDorsten,Oded Langer,James M. Roberts +20 more
TL;DR: Treatment with metronidazole did not reduce the occurrence of preterm labor, intraamniotic or postpartum infections, neonatal sepsis, or admission of the infant to the neonatal intensive care unit.
Journal ArticleDOI
Cost of hospitalization for preterm and low birth weight infants in the United States.
Rebecca B. Russell,Nancy S. Green,Nancy S. Green,Claudia A. Steiner,Susan Meikle,Jennifer L. Howse,Karalee Poschman,Todd Dias,Lisa Potetz,Michael J. Davidoff,Karla Damus,Karla Damus,Joann Petrini,Joann Petrini +13 more
TL;DR: Costs per infant hospitalization were highest for extremely preterm infants, although the larger number of moderately preterm/low birth weight infants contributed more to the overall costs, suggesting that major infant and pediatric cost savings could be realized by preventing preterm birth.
Related Papers (5)
Prevention of recurrent preterm delivery by 17 alpha-hydroxyprogesterone caproate.
Paul J. Meis,Mark A. Klebanoff,Elizabeth Thom,Mitchell P. Dombrowski,Baha M. Sibai,Atef H. Moawad,Catherine Y. Spong,John C. Hauth,Menachem Miodovnik,Menachem Miodovnik,Michael W. Varner,Kenneth J. Leveno,Steve N. Caritis,Jay D. Iams,Ronald J. Wapner,Deborah L. Conway,Mary Jo O'Sullivan,Marshall W. Carpenter,Brian M. Mercer,Susan M. Ramin,John M. Thorp,Alan M. Peaceman +21 more