Hao Huang

TL;DR: Letrozole was associated with higher live-birth and ovulation rates among infertile women with the polycystic ovary syndrome and with higher incidences of fatigue and dizziness compared with clomiphene.

TL;DR: Common genetic susceptibility loci in European ancestry women for the National Institutes of Health PCOS phenotype are identified, which confers the highest risk for metabolic morbidities, as well as reproductive hormone levels, and implicate neuroendocrine changes in disease pathogenesis.

TL;DR: In women with unexplained infertility, ovarian stimulation with letrozole resulted in a significantly lower frequency of multiple gestation but also a higher frequency of live birth, as compared with gonadotropin but not asCompared with clomiphene.

TL;DR: Two mechanisms, activation of nonselective cation channels and the sodium/calcium exchanger are suggested, which may function to initiate broad activation, rather than the cell-type selective activation or inhibition reported for many other compounds that modulate energy homeostasis.

TL;DR: The robust excitation evoked by HcrT-2 on cortically projecting glutamate PVT neurons could generate substantial excitation in multiple layers of the mPFC, adding to the more selective direct excitatory actions of Hcrt in the mFFC and potentially increasing cortical arousal and attention to limbic or visceral states.