Journal ArticleDOI
Glucose transport families SLC5 and SLC50
TLDR
The atomic structure of a closely related bacterial homolog has been solved and the structural core is common to six unrelated transporters, e.g. members of the SLC6 family of neurotransporter, and the conclusion that these work by a similar mechanism.About:
This article is published in Molecular Aspects of Medicine.The article was published on 2013-04-01. It has received 212 citations till now. The article focuses on the topics: Cotransporter & Glucose transporter.read more
Citations
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Journal ArticleDOI
SLC transporters as therapeutic targets: emerging opportunities
TL;DR: Current and investigational drugs that modulate SLC transporters, as well as promising drug targets, are highlighted.
Journal ArticleDOI
Glucose transporters in cancer - from tumor cells to the tumor microenvironment.
TL;DR: Some of the deregulation mechanisms of glucose transporters, their genetic and pharmacological targeting in cancer, and new functions they may have in nontumor cells of the tumor environment or beyond glucose uptake for glycolysis are discussed.
Journal ArticleDOI
Glucose Transporters at the Blood-Brain Barrier: Function, Regulation and Gateways for Drug Delivery.
TL;DR: The distribution, function and regulation of glucose transporters at the blood-brain barrier are described and the effects on glucose transporter expression and distribution of hypoglycemia and hyperglycemia associated with diabetes and oxygen/glucose deprivation associated with cerebral ischemia are considered.
Journal ArticleDOI
Sodium-Glucose Co-transporters and Their Inhibition: Clinical Physiology
TL;DR: This review focuses on the quantitative pharmacology of SGLT2 inhibitors, which can be exploited to discover new physiology, in the heart, kidney, and brain.
Journal ArticleDOI
Functional expression of sodium-glucose transporters in cancer.
Claudio Scafoglio,Bruce A. Hirayama,Vladimir Kepe,Jie Liu,Chiara Ghezzi,Nagichettiar Satyamurthy,Neda A. Moatamed,Jiaoti Huang,Hermann Koepsell,Jorge R. Barrio,Ernest M. Wright +10 more
TL;DR: It is found that SGLT2 is functionally expressed in pancreatic and prostate adenocarcinomas, and evidence that S GLT2 inhibitors block glucose uptake and reduce tumor growth and survival in a xenograft model of pancreatic cancer is provided.
References
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Journal ArticleDOI
The DNA sequence of human chromosome 21
Masahira Hattori,Asao Fujiyama,Todd D. Taylor,Hidemi Watanabe,Tetsushi Yada,H.-S. Park,Atsushi Toyoda,Kazuo Ishii,Yasushi Totoki,Dong-Kug Choi,Eiichi Soeda,Misao Ohki,T. Takagi,Yoshiyuki Sakaki,S. Taudien,K. Blechschmidt,A. Polley,U. Menzel,Jean-Maurice Delabar,K. Kumpf,R. Lehmann,David Patterson,Kathrin Reichwald,Andreas Rump,M. Schillhabel,A. Schudy,W. Zimmermann,André Rosenthal,Jun Kudoh,Kazunori Shibuya,Kazuhiko Kawasaki,Shuichi Asakawa,Ai Shintani,Takashi Sasaki,Kentaro Nagamine,Susumu Mitsuyama,Stylianos E. Antonarakis,Shinsei Minoshima,Nobuyoshi Shimizu,Gabriele Nordsiek,K. Hornischer,P. Brandt,M. Scharfe,O. Schön,A. Desario,J. Reichelt,G. Kauer,H. Blöcker,Juliane Ramser,Alfred Beck,Sven Klages,Steffen Hennig,L. Riesselmann,Emilie Dagand,Thomas Haaf,S. Wehrmeyer,K. Borzym,Katheleen Gardiner,Dean Nizetic,Fiona Francis,Hans Lehrach,Richard Reinhardt,Marie-Laure Yaspo +62 more
TL;DR: In this article, the authors reported the sequence and gene catalogue of the long arm of chromosome 21 and sequenced 33,546,361 base pairs (bp) of DNA with very high accuracy, the largest contig being 25,491,867 bp.
Journal ArticleDOI
Sugar transporters for intercellular exchange and nutrition of pathogens
Li Qing Chen,Bi Huei Hou,Sylvie Lalonde,Hitomi Takanaga,Mara L. Hartung,Xiao Qing Qu,Woei Jiun Guo,Jung Gun Kim,William Underwood,Bhavna Chaudhuri,Diane Chermak,Ginny Antony,Frank F. White,Shauna Somerville,Mary Beth Mudgett,Wolf B. Frommer +15 more
TL;DR: Using optical glucose sensors, a new class of sugar transporters are identified, named SWEETs, and it is shown that at least six out of seventeen Arabidopsis, two out of over twenty rice and two of seven homologues in Caenorhabditis elegans, and the single copy human protein, mediate glucose transport.
Journal ArticleDOI
Biology of Human Sodium Glucose Transporters
TL;DR: A personal review of advances in the genetics, molecular biology, biochemistry, biophysics, and structure of SGLTs, including cotransporters for sugars, anions, vitamins, and short-chain fatty acids.
Journal ArticleDOI
The DNA sequence of human chromosome 22
Ian Dunham,Nobuyoshi Shimizu,Bruce A. Roe,S. Chissoe,Adrienne Hunt,Joanna Collins,Richard Bruskiewich,David Beare,Michele Clamp,Luc J. Smink,R Ainscough,J P Almeida,A K Babbage,C L Bagguley,J Bailey,K F Barlow,K Bates,O. Beasley,Christine P. Bird,S. Blakey,Anne Bridgeman,D. Buck,J. Burgess,J. Burgess,W Burrill,John Burton,C Carder,Nigel P. Carter,Yuan Chen,Graeme T Clark,S. M. Clegg,V. Cobley,Charlotte G. Cole,R. E. Collier,R. Connor,D. Conroy,N Corby,G. J. Coville,Antony V. Cox,J. C. Davis,J. C. Davis,Elisabeth Dawson,Pawandeep Dhami,C. Dockree,S. J. Dodsworth,Richard Durbin,Andrew D. Ellington,Kathryn L. Evans,J. M. Fey,K. Fleming,Lisa French,A. A. Garner,James G. R. Gilbert,Melanie E. Goward,Darren Grafham,Mark Griffiths,C. Hall,C. Hall,Rebekah Hall,G. Hall-Tamlyn,R. W. Heathcott,R. W. Heathcott,Shuk-Mei Ho,S. Holmes,Sarah E. Hunt,Matthew Jones,J K Kershaw,A M Kimberley,A. King,Gavin K. Laird,Cordelia Langford,Margaret A. Leversha,Christine Lloyd,D. M. Lloyd,I. D. Martyn,M Mashreghi-Mohammadi,Lucy Matthews,O. T. McCann,Joseph L. McClay,Stuart McLaren,Amanda McMurray,Sarah Milne,B. J. Mortimore,C. Odell,R. Pavitt,A. V. Pearce,D. Pearson,Benjamin Phillimore,Sam Phillips,Robert W. Plumb,H. Ramsay,Y. Ramsey,Lesley J. Rogers,Mark T. Ross,Carol Scott,Harminder Sehra,C. D. Skuce,S. Smalley,Michelle Smith,Carol Soderlund,L. Spragon,Charles A. Steward,John Sulston,R. M. Swann,M. Vaudin,M. Vaudin,Melanie M. Wall,J. M. Wallis,M. N. Whiteley,M. N. Whiteley,Dave Willey,L. Williams,Scott M. Williams,H. Williamson,H. Williamson,T. E. Wilmer,Laurens G. Wilming,Charmain L. Wright,Tim Hubbard,David R. Bentley,Stephan Beck,Jane Rogers,Shinsei Minoshima,Kazuhiko Kawasaki,Takashi Sasaki,Shuichi Asakawa,Jun Kudoh,Ai Shintani,Kazunori Shibuya,Y. Yoshizaki,Noriaki Aoki,Susumu Mitsuyama,Feng Chen,L. Chu,Judy S. Crabtree,Stéphane Deschamps,A. Do,T. Do,Angela Dorman,F. Fang,Y. Fu,P. Hu,Axin Hua,Steve Kenton,Hongshing Lai,H. I. Lao,Jennifer Lewis,S. Lewis,Shaoping Lin,P. Loh,Eda Malaj,T. Nguyen,Huaqin Pan,S. Phan,S. Qi,Y. Qian,L. Ray,Q. Ren,S. Shaull,D. Sloan,L. Song,Q. Wang,Yuhang Wang,Z. Wang,Jim White,D. Willingham,H. Wu,Ziyun Yao,M. Zhan,Genwei Zhang,Joseph A. Murray,N. Miller,Patrick Minx,Robert S. Fulton,David W. Johnson,G. Bemis,David Bentley,H. Bradshaw,S. Bourne,Matt Cordes,Zijin Du,Lucinda Fulton,D. Goela,Tina Graves,J. Hawkins,K. Hinds,K. Kemp,Phil Latreille,Dan Layman,Philip Ozersky,Tracy Rohlfing,Paul Scheet,C. Walker,A. Wamsley,Patricia Wohldmann,Kymberlie H. Pepin,Joanne O. Nelson,Ian F Korf,Joseph A. Bedell,LaDeana W. Hillier,Elaine R. Mardis,Robert H. Waterston,Richard K. Wilson,Beverly S. Emanuel,Tamim H. Shaikh,Hiroki Kurahashi,Sulagna C. Saitta,M. L. Budarf,Heather E. McDermid,Alexander Johnson,A. C.C. Wong,Bernice E. Morrow,Lisa Edelmann,U. J. Kim,Hiroaki Shizuya,Melvin I. Simon,Jan P. Dumanski,Myriam Peyrard,Darek Kedra,Eyal Seroussi,Ingegerd Fransson,I. Tapia,Carl E.G. Bruder,K. P. O'Brien +223 more
TL;DR: The sequence of the euchromatic part of human chromosome 22 is reported, which consists of 12 contiguous segments spanning 33.4 megabases, contains at least 545 genes and 134 pseudogenes, and provides the first view of the complex chromosomal landscapes that will be found in the rest of the genome.